PluchinoLab - Regenerative Neuroimmunology

15/10/2025

The Rogue Cell: Scientists Uncover a Key Driver of Progressive Multiple Sclerosis

Researchers at Cambridge University have identified a strange, malfunctioning brain cell that reverts to a developmental state while aging prematurely, fueling the chronic inflammation that defines this debilitating disease.

Researchers have identified a strange, malfunctioning brain cell that reverts to a developmental state while aging prematurely, fueling the chronic inflammation that defines this debilitating disease. Multiple sclerosis (MS) is a relentless condition where the body's own immune system turns against....

10/10/2025

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell

Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the persistent inflammation characteristic of the disease. The discovery, reported today in Neuron, is a significant step towards understanding the compl...

10/10/2025

Nuova scoperta nelle forme progressive di sclerosi multipla: identificato un raro tipo di cellula cerebrale coinvolta nell’infiammazione

La ricerca condotta da un team internazionale e pubblicata sulla rivista Neuron, è stata sostenuta anche da AISM e la sua Fondazione

10/10/2025

Unusual Brain Cell Type Linked to Progressive MS, Could Point to Therapeutics

“Disease in a dish” study indicates DARG cells may be contribute to persistent inflammation characteristic of progressive MS.

10/10/2025

🚀 Exciting Breakthrough in Progressive MS Research! 🚀

My team at the University of Cambridge, in collaboration with Isabel Beerman at the National Institute on Aging (and many other friends), has uncovered a potentially ground-breaking discovery in the fight against hashtag (MS). This work was spearheaded by Alexandra Nicaise, a key member of my team at Cambridge and
co-lead author, along with Irina Mohorianu, co-senior author, also based at
Cambridge.

Using a pioneering ‘disease in a dish’ model, we identified a novel brain cell type—disease-associated radial glia-like cells (DARGs). These cells originate from mature astroglia undergoing adaptive developmental reprogramming and appear to play a central role in driving hashtag and hashtag in progressive MS.
Notably, DARGs revert to an early developmental stage and exhibit features of premature hashtag , actively contributing to the damaging environment within the brain.

This discovery opens new avenues for targeted therapies that could transform treatment for this devastating disease, offering hope to thousands. Our findings may also provide insights into other neurodegenerative conditions.

Stay tuned as we delve deeper into the molecular machinery of hashtag and explore their potential as therapeutic targets!

Park, Nicaise, Tsitsipatis, and colleagues discover transcriptional and epigenetic markers in human PMS iNSCs and fibroblasts that may underlie their senescent and inflammatory state. Novel DARGs with the potential to fuel smoldering inflammation are found in chronic lesions from people with PMS.

10/10/2025

‘Disease in a dish’ study of progressive MS finds critical role for unusual type of brain cell

https://www.cam.ac.uk/research/news/disease-in-a-dish-study-of-progressive-ms-finds-critical-role-for-unusual-type-of-brain-cell?fbclid=IwY2xjawNWCdFleHRuA2FlbQIxMQABHnJHKV1y54iPC2V-wGYWAYXSpeoMMsHWMxAsqxITkagaIvY2yfiUxGn33Y5T_aem_gnZdbiqf5gBVnPt-zx7p0g

Scientists have identified an unusual type of brain cell that may play a vital role in progressive multiple sclerosis (MS), likely contributing to the

08/10/2025

Nobel Laureate Professor Sir John Gurdon dies aged 92

Nobel Laureate Professor Sir John Gurdon dies aged 92

06/10/2025

22/07/2025

Delighted to have had this long and absolutely enjoyable chat with Barry Singer MD about stem cells, multimodal mechanisms of action, promises and expectations, and concrete possibilities — up to the most recent first-in-human clinical trials aiming to apply the most sophisticated principles of regenerative neuroimmunology to the development of therapeutically effective advanced treatments for patients with progressive multiple sclerosis. I hope you appreciate the effort.

International Progressive MS Alliance University of Cambridge Department of Clinical Neurosciences Cambridge RESTORE

Podcast Episode · MS Living Well: Key Info from Multiple Sclerosis Experts · 22/07/2025 · 46m