Cell Guidance Systems

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Cell Guidance Systems

Cell Guidance Systems provides innovative life science research tools and services.

Cell Guidance Systems is a regenerative medicine company providing reagents and services for cell based research and developing protein therapeutics using its PODS platform.

22/12/2025

EVs: complex cellular communication

Compared to simple cytokines, extracellular vesicles are very complex means of cellular communication. This complexity and ability to deliver multiple "notes" at the same time may make EVs difficult to decipher, but also holds the promise of far more powerful therapeutic composition.

https://lnkd.in/eMR8iZ-B

15/12/2025

Creating robust chemokine gradients to create cellular niches is simple with PODS sustained release chemokines.

Read more in our weekly blog

https://lnkd.in/eJWvY4sq

08/12/2025

Not so rare

Rare diseases are so numerous that they are collectively very common. The prospects for people with rare diseases are improving as most diseases are genetic and the tools to identify and correct these errors are improving.

Read more

https://lnkd.in/eGYfwjU3

01/12/2025

Exosomes in 2026: hype and potential

Over the last few years, exosomes have increasingly been promoted for their cosmetic benefits. The risk is that poor quality data from cosmetics impacts efforts to develop EVs with clinical benefits, particularly for wound healing applications.

Read more in our blog

https://lnkd.in/eYzbJhPv

24/11/2025

The Hunters gene therapy breakthrough announced today highlights the important role of medical charities in funding clinical research for drugs that would not be commercially viable.

Read the full blog:

https://lnkd.in/ex2zZUdc

27/10/2025

A novel “shaking sensor” has been developed that enables real-time monitoring of cytokines – paving the way for continuous inflammation tracking and insights into acute and chronic disease management.

Read more:

https://www.cellgs.com/blog/how-does-a-shaking-sensor-provide-real-time-cytokine-monitoring.html

13/10/2025

How Many More Immune Cells Remain to Be Identified?

With the awarding of a Nobel Prize for the discovery of regulatory T cells, we ask how many immune cells remain to be identified. This isn’t just academic; each newly discovered cell could reshape how we understand immunity, disease, and therapeutics.

Read more here:

https://lnkd.in/e_mJ4t7g

06/10/2025

Losing retinal ganglion cells (RGCs) has long meant irreversible vision loss — but that may be changing.

Researchers using PODS® micro-cages (Polyhedrin Delivery System) loaded with growth factors (BDNF + GDNF) have shown dramatic improvements in RGC survival and regeneration — both in vitro and in vivo.

✅ 15× higher survival of transplanted human RGCs
✅ Neuroprotective effects for host retinal cells
✅ Sustained, localized growth factor release

This could shift eye-repair strategies from simple replacement to “support + replace.”

Read more in Cell Guidance Systems’ latest post:
https://lnkd.in/eD5j32Ka

29/09/2025

Under pressure: Modeling glaucoma using sustained cytokine release PODS

Researchers have engineered an in vitro model of the trabecular meshwork (TM) mimicking chronic disease by combining biomimetic collagen scaffolds with PODS® microcrystals that gradually release TGF-β2 .

👉 Check it out:

https://lnkd.in/eGKB9Ur7

22/09/2025

Climate change 🌍 not just rising seas: It may also reshape our biology.

Our latest blog explores how heat, pollution, and disrupted light cycles can damage DNA, alter gene expression, and potentially increase cancer risk. Vulnerable populations may face the greatest impact, making this a critical public health issue.

Read the full article

https://lnkd.in/ep3-aKJx

15/09/2025

Can there be any science without standards?

Setting Standards: Making Research Scientific

Advancing science isn’t just about new discoveries. It’s about how we measure, compare, and agree.

https://lnkd.in/eJb5JgM2

08/09/2025

New on the CellGS Blog: What Are the Most Effective Ways to Concentrate EVs?

EVs often need to be concentrated before purification and downstream analysis. This can be tricky, especially when working with large sample volumes and aiming to preserve both purity and bioactivity. We break down all the options with a clear, method-by-method guide.

https://lnkd.in/e5pY-7mA

Address

Maia Building, Babraham Research Campus
Cambridge
CB223AT

Website

https://www.cellgs.com/mc-pods-home.htm?E2EPv=1

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