28/04/2026
A large BMJ study of over 800,000 women has found that menopausal hormone therapy is not associated with increased mortality. This is important, because for many women, decisions around HRT are still shaped by fear originating from early interpretations of the Women’s Health Initiative. What this study adds is large-scale, real-world data with over 14 years of follow-up, showing no clear increase in all-cause, cardiovascular, or cancer-related mortality in women using HRT . There were even signals of reduced mortality in specific groups, such as women who had undergone bilateral oophorectomy.
But the response to this kind of evidence is becoming just as problematic. There is a growing amount of noise in the menopause space, with some so-called experts claiming that HRT dramatically reduces heart disease, prevents chronic illness, and is broadly protective for long-term health. That is not what this study shows. Cause-specific mortality differences were small, inconsistent, and should be interpreted with caution .
We’ve moved from a narrative of fear to, in some spaces, a narrative of overcorrection. From “HRT is dangerous” to “HRT protects against everything.” Neither reflects the reality of the evidence.
HRT is an effective treatment for menopausal symptoms and is safe for many women when appropriately prescribed. It may also have benefits in specific contexts. But it is not a replacement for other key components of long-term health, including strength training, cardiovascular fitness, and broader lifestyle and environmental factors.
If you want more information about the latest research into HRT we will cover this in our upcoming Menopause Masterclass.
This will take place online on 11th May at 7pm. All you need to do is comment below Masterclass or hit the link in bio to purchase a ticket.
Mikkelsen AP, Bergholt T, Lidegaard Ø, Scheller NM. Menopausal hormone therapy and long term mortality: nationwide, register based cohort study. BMJ. 2026 Feb 18;392:e085998. doi: 10.1136/bmj-2025-085998. PMID: 41708152; PMCID: PMC12915068.