11/11/2025
Is the general understanding of dopamine and its effects on ADHD completely wrong?
Many people still believe ADHD is simply caused by “low dopamine.” But recent evidence points towards something more accurate and far more helpful.
Rather than a blanket shortage, research suggests that the dopamine system in ADHD is dysregulated (Badgaiyan et al., 2015, Sikström and Söderlund, 2022, MacDonald et al., 2024).
The baseline signal, known as tonic dopamine, can be lower, and the task-related bursts, known as phasic dopamine, can be more uneven or less well regulated (ADxS.org, n.d.).
A useful analogy is thinking of the brain’s dopamine system like a Wi-Fi connection. The signal is there, but it can be unstable, dropping in and out, or spiking at the wrong times. ADHD medication does not add dopamine, it helps the signal stay more consistent so the brain can use it more effectively (Badgaiyan et al., 2015).
This model feels more accurate and compassionate, especially for women in perimenopause and menopause, where fluctuating hormone levels create a double whammy, as not only is dopamine production affected, but also how it is used, taken up, and regulated in the brain (MacDonald et al., 2024).
Do you think this model makes more sense than the generalised “low dopamine” explanation that is often shared online? I would love to hear your thoughts.
References
Badgaiyan, R.D., Sinha, S., Sajjad, M. and Wack, D.S. (2015) ‘Attenuated tonic and enhanced phasic release of dopamine in Attention-Deficit/Hyperactivity Disorder’, PLoS ONE, 10(3), e0117530. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC4589406/
MacDonald, H.J., Kleppe, R. and Szigetvari, P.D. (2024) ‘The dopamine hypothesis for ADHD: An evaluation of evidence accumulated from human studies and animal models’, Neuroscience and Biobehavioural Reviews, 156, pp. 318–330. Available at: https://pmc.ncbi.nlm.nih.gov/articles/PMC11604610/
Sikström, S. and Söderlund, G. (2022) ‘Stimulus dependent dopamine release in Attention-Deficit/Hyperactivity Disorder’, Psychological Review. Available at:https://www.gu.se/sites/default/files/2022-11/GS%20Psych%20Rev.pdf