20/12/2022
Active folate and human health
During pregnancy, the body requires 5–10-fold higher folate intakes . Folate is necessary for cell growth, cell division, cell synthesis and repair of DNA.
5-MTHF as a natural folate support to the aging process
Numerous physical and physiological changes occur during the ageing processes. Ageing is associated with changes in gastrointestinal function that could affect the absorption of different folate forms. Partly because of these changes, the risk of deficiencies of vitamin B12, folate and iron highly occur in older people. To prevent the blood formation, neurologic function, and cardiovascular function issues that they can lead to, nutritive supplement intake is recommended.
Thanks to its various health claims (EFSA approved ) related to psychological functions, reduction of tiredness and fatigue, cell division, normal homocysteine metabolism and well function of the immune system, folate is a good solution for elderly people.
Vitamin B12 deficiency has a prevalence approaching 20% in the elderly, and it is difficult to recognize. Folic acid intake and supplementation may mask vitamin B12 deficiency with a delay in diagnosis which can lead to anemia and peripheral nerve damage.
On the contrary, the 5-MTHF doesn’t mask the vitamin B12 deficiency and does not affect its possible diagnosis.
The potential role of the active folate in cardiovascular health
Folate deficiency is frequently associated with elevated plasma homocysteine (Hcy) concentration – hyperhomocysteinemia – that is considered a recognized risk factor for cardiovascular disease (CVD) and may also be associated with hypertension. Folate is an important regulator of Hcy metabolism: clinical studies report evidence that folate helps to maintain its normal plasma concentrations and its supplementation can reduce cardiovascular disease risk by lowering homocysteine levels.
Brain, mood and cognition health can benefit from active folate.
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