31/03/2026
Think of serum ferritin like a vault in a bank: holding all your hard earnt £££ (iron) safely inside. When we test for ferritin, most people assume that's exactly what we're measuring: the contents of that vault.
But - we're not measuring the vault at all. We're measuring the shadow it casts.
Because ferritin actually is an intracellular storage protein. It lives inside hepatocytes(liver cells) and macrophages, not in the bloodstream. What a blood test picks up is the tiny amount that leaks out. That leak tells you something about what's happening inside those cells but it is not the iron itself.
Usually……Until inflammation enters the picture.
Because IL-6 (the cytokine at the heart of every chronic inflammatory state) drives ferritin synthesis through a completely separate pathway. Nothing to do with how much iron is actually stored.
Which means a ferritin of 70 in a woman with IBD or RA for example is not the same as a ferritin of 70 in a woman with no inflammation. Same number. Completely different clinical meaning.
Swipe through for the full breakdown and to understand why ferritin is a shadow and not the actual vault in the bank holding all the ££££!