22/02/2026
Collagen repairs connective tissue by acting as a biological scaffold that supports new tissue formation and regulates the body’s natural healing stages. It is the most abundant structural protein in the body, providing the necessary strength and flexibility to bones, tendons, ligaments, and skin. The repair process typically occurs in four overlapping phases:
▶️Hemostasis & Inflammation: Upon injury, collagen exposure triggers the clotting cascade to stop bleeding. It then attracts immune cells to the site to clear debris and release anti-inflammatory cytokines, such as interleukin-10, which help transition the wound toward a reparative state.
▶️Proliferation: Specialized cells called fibroblasts migrate to the injured area and begin synthesizing new collagen fibers. Initially, the body produces Type III collagen, which forms a flexible, rapid-crosslinking matrix to stabilize the repair site.
▶️Remodeling: Over weeks to months, the temporary Type III collagen is replaced by Type I collagen, which is more durable and organized. Enzymes help reorganize these fibers into a dense network that restores up to 80–85% of the original tissue’s tensile strength.
Dietary collagen, often consumed as hydrolyzed peptides, may support this process by providing essential amino acid “building blocks” like glycine and proline. These bioactive peptides can stimulate fibroblasts to increase natural collagen production and improve joint functionality.
PMID: 34491424