08/04/2026
Something I wish more people knew about anaphylaxis:
It’s not always just “allergic person + allergen = reaction.”
Sometimes seemingly random things can cause reactions, due to a combination of factors.
This is called ‘Co-factors’, and they can dramatically lower the threshold for a reaction, or turn a mild response into a severe one.
Although it’s rare, we see this at [**Kitt Medical**](https://www.linkedin.com/feed #) fairly often, and these ones catch people out the most:
Exercise - eating something when resting could be fine, but eating the same thing and then going for a run could trigger full anaphylaxis.
NSAIDs - taking ibuprofen for a headache could lead to a reaction to a food that’s never caused problems before.
Alcohol - drinks like wine increase gut permeability and mast cell sensitivity, which can lead to reactivity where there usually wouldn’t be.
Stress and poor sleep - this one is not just in your head, these genuinely alter immune thresholds, which can lead to severe reactions.
Menstrual cycles - oestrogen primes mast cells. Some women even react at the same point each month.
Just another reason to always be prepared.