London School of Hygiene & Tropical Medicine: Clinical Trials Unit

22/01/2025

In October 2024, the London School of Hygiene & Tropical Medicine I’M WOMAN Trial team visited sites in Tanzania and witnessed firsthand how simple it could be to administer a life-saving drug for treating severe bleeding after childbirth ( ).

⏰ Intravenous TXA injection takes up to 10 minutes and needs a high level of clinical training.

💉Imagine if giving tranexamic acid (TXA) could be as easy as an injection into the muscle. Intramuscular administration is faster, more efficient, and requires less training for healthcare workers.

The trial teams in Tanzania, Nigeria and Pakistan aim to expand access to this life-saving drug so more women can be treated and maternal deaths reduced.
Learn more 👇 https://bit.ly/42fUwIn

02/12/2024

The I’M WOMAN Trial team in Tanzania pledged to improve access to tranexamic acid (TXA) to reduce maternal deaths that result from severe postpartum bleeding.

How will they apply it to their roles? Doctors, nurses and midwives from the trial team pledge to:

- Administer TXA within three hours of birth
- Raise awareness of TXA for reducing life-threatening bleeding
- Recruit more eligible women to the trial

🤝 collaborating with ten hospital sites, including the University of Dar es Salaam College of Health and Allied Sciences and Mbeya Zonal Referral Hospital.

Learn more about how the I’M WOMAN Trial is advocating for maternal health in obstetrics and gynaecology: https://bit.ly/3Z3yuoI

14/04/2022

What has held back the implementation of tranexamic acid in the USA?

New comment as published today in The Lancet discusses for in the and asks, is prejudice a barrier to saving lives?

The CRASH-2 clinical trial results were published in June, 2010.1,2 Our global collaboration had randomly allocated 20 211 trauma patients from 274 hospitals in 40 countries to receive tranexamic acid, an antifibrinolytic agent to prevent or reduce bleeding, or placebo. Timely tranexamic acid trea...

09/03/2022

New research car initiative by South Central Ambulance Service sees dedicated paramedics arrive rapidly on scene to deliver treatment to head injury patients.⏳🚑

Learn more about the pioneering work here:

https://youtu.be/zaR3eiQ4Jlc

Find out how South Central Ambulance Service (SCAS) has set up their innovative Research Car Initiative that hopes to quickly reach older head injury patients

20/05/2021

Today marks ✨International Clinical Trials Day✨!

No better time to celebrate and thank ALL of the healthcare professionals, researchers, participants & families that have been involved in each of our trials, & contributed to life saving and life changing research.

13/05/2021

Wishing all our Muslim friends and collaborators a very happy , full of good health and peace for all.

23/04/2021

🎉 Our ( for mild in older adults) has officially begun recruitment! 🎉

Huge congrats to St George's Hospital
St George's University Hospitals NHS Foundation Trust PI Heather Jarman & all the team on getting the 1st! Who will be next to recruit?!💪

More trial info @ https://ctu.lshtm.ac.uk/crash-4/

20/04/2021

🌍🩸 Without the participation of tens of thousands of patients from about 50 countries, these results on ( ) would not exist

To help reduce deaths from , visit www.txacentral.lshtm.ac.uk to see the evidence they have provided and learn about some of their stories

16/04/2021

🩸Introducing: TXA Central

This website collates evidence from on ( ) and is a resource for caring for patients with acute severe

Find out more at: https://ctu.lshtm.ac.uk/txa-central/

17/03/2021

Are you interested in understanding the fundamental principles of Clinical Trials?

The Medical Statistics Department at London School of Hygiene & Tropical Medicine are running an online short course: Essentials of Clinical Trials

Places are limited

For further information visit: https://www.lshtm.ac.uk/study/courses/short-courses/clinical-trials

03/03/2021

Called by World Health Organization (WHO), the evaluation of potential benefits and harms of other routes of administration is a priority to save from during

The WOMAN Trials-PharmacoTXA trial hopes to achieve just that

01/03/2021

Brilliant work by collaborators in Pakistan, Nigeria and Zambia - despite COVID-19 pandemic, The WOMAN Trials has recruited over 2800 women with moderate and severe anaemia already!

Read more about the trial: https://ctu.lshtm.ac.uk/woman-2-trial/