23/02/2026
Why Fertility Treatment Works Differently for Different Women
This review explains that small genetic differences in the FSH hormone and its receptor can strongly influence how a woman’s ovaries respond to fertility treatment. These genetic variations help explain why some women do not respond well to standard IVF medication doses, while others may respond too strongly and develop side effects.
By identifying these genetic markers, doctors can better predict who may need higher or lower hormone doses and who may be at risk of poor or excessive response. The research brings together data from around the world showing how these genes affect egg numbers, hormone levels, and treatment outcomes.
The key message is that fertility treatment does not need to be “trial and error.” Using genetics allows IVF to be more personalised, safer, and potentially more successful by matching treatment to the individual rather than using the same protocol for everyone.
Pharmacogenetics of FSH Action in the Female. Front. Endocrinol. 10:398. doi: 10.3389/fendo.2019.00398