18/02/2026
✨ Profhilo vs Polynucleotides – What’s the Difference? ✨
These two treatments are often compared — but they work very differently and are used for different skin goals.
Let’s break it down 👇
💧 Profhilo
Profhilo is a high-concentration hyaluronic acid injectable designed to deeply hydrate and stimulate collagen and elastin.
🔬 How it works:
It spreads beneath the skin after injection, improving overall skin laxity and hydration. It’s not a filler — it doesn’t add volume or contour — but it gives that smooth, plump, “lit-from-within” glow.
✨ Best for:
• Crepey or thinning skin
• Loss of firmness
• Dull, dehydrated skin
• Early signs of ageing
• Full-face rejuvenation
💉 Typically done in 2 sessions, 4 weeks apart.
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🧬 Polynucleotides
Polynucleotides are DNA-derived biostimulators that focus on repair and regeneration.
🔬 How they work:
They stimulate fibroblasts, improve tissue repair, reduce inflammation, and strengthen the skin barrier. This makes them incredible for improving skin quality and delicate areas.
✨ Best for:
• Under-eye crepey skin
• Dark circles
• Acne scarring
• Sensitive or inflamed skin
• Neck & delicate areas
• Skin that needs repair rather than just hydration
💉 Usually recommended as a course of 2–3 treatments.
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🌟 So which is better?
Neither is “better” — it depends on your skin goals.
✔ Choose Profhilo when you want overall hydration, firmness, and glow.
✔ Choose Polynucleotides when you need regeneration, repair, or treatment in delicate areas.
In some cases, they can even be combined in a treatment plan for optimal results.
The key is personalised consultation and choosing the right treatment for your skin.