16/01/2026
What really happens to your skin after menopause — and why oestrogen matters.
Oestrogen is not just a reproductive hormone.
It is a key regulator of skin biology.
After menopause, falling oestrogen levels lead to measurable, structural changes in skin:
• Slower keratinocyte turnover → dull, thinner epidermis
• Reduced fibroblast activity → less collagen and elastin
• Impaired wound healing and barrier repair
• Increased inflammation
• Dryness, fragility, fine lines appearing faster
This is skin ageing at a cellular level, not “bad skincare.”
How topical oestrogen works in the skin
Skin contains oestrogen receptors (ER-α and ER-β) in keratinocytes, fibroblasts, and dermal blood vessels.
When topical oestrogen is applied under medical supervision, it can:
• Improve epidermal thickness
• Increase collagen synthesis
• Enhance hydration and barrier function
• Improve elasticity and skin resilience
• Support healthier skin turnover
This is biological support, not cosmetic camouflage.
Who may benefit
• Postmenopausal women with fragile, thin, dry skin
• Women who notice accelerated ageing after menopause
• Patients whose skin no longer responds to standard cosmeceuticals
Important clinical points
✔ This is prescription-only
✔ Dosing, formulation, and site of application matter
✔ Not suitable for everyone — individual assessment is essential
✔ Facial oestrogen is not the same as systemic HRT
When used correctly, topical oestrogen can be a powerful adjunct in managing menopausal skin changes — alongside sun protection, retinoids, regenerative treatments, and lifestyle support.
Menopausal skin doesn’t need more marketing.
It needs hormone-aware medicine.