26/12/2025
đ§Ź New aging science: itâs not just calories â itâs amino acids
A new paper (Chen et al.) just added an important piece to the longevity puzzle.
Researchers looked at plasma metabolites linked to epigenetic age acceleration (how fast your biology is ageing, not your birthday).
đ Of all metabolic pathways studied, cysteine & methionine metabolism came out as the most strongly associated with accelerated ageing.
Let that sink in for a second.
Why this matters (in plain English)
Methionine and cysteine are sulphur-containing amino acids.
They sit at the crossroads of: ⢠DNA methylation (epigenetic clocks)
⢠Oxidative stress
⢠Inflammation
⢠mTOR signalling
⢠Glutathione (your main antioxidant system)
In other words:
how you process protein may influence how fast you age.
Not calories alone.
Not supplements alone.
Not exercise alone.
This DOESNâT mean âprotein is badâ
Important clarification before the internet loses its mind đ
This isnât saying: â stop eating protein
â lose muscle
â live on lettuce
It is saying: âď¸ the type, balance, and timing of protein matters
âď¸ chronic excess of methionine-heavy foods may push ageing signals faster
âď¸ supporting cysteine â glutathione pathways may be protective
Rodent data has shown this for years.
Now weâre seeing human metabolomic + epigenetic evidence catching up.
Practical takeaways (no extremes required)
Things that align with this research:
⢠Moderate methionine, donât eliminate it
â Less red meat & cheese
â More plant proteins, fish, mixed sources
⢠Support glutathione production
â Cruciferous veg, garlic, onions
â Training (yes, exercise boosts this)
⢠Avoid constant feeding â Intermittent fasting / calorie cycling reduces mTOR pressure
â Likely mimics methionine restriction effects
⢠Polyphenols matter â Green tea, cocoa, olive oil, turmeric
â These interact with redox + methylation pathways
Sound familiar?
It should â this overlaps strongly with what we already know improves healthspan.
The bigger message
Longevity isnât about hacks.
Itâs about reducing chronic biological stress â metabolic, inflammatory, oxidative â while maintaining strength and function.
This paper reinforces a simple idea:
đ Ageing is metabolic before it is structural
And once metabolism shifts, everything else follows.
If you want, I can break down:
⢠how this ties into fasting
⢠why muscle still matters
⢠how to apply this without overthinking your diet
Drop a comment đ