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Scientific research on cannabis-based compounds continues to grow — and the findings are nuanced. A landmark report from...
23/02/2026

Scientific research on cannabis-based compounds continues to grow — and the findings are nuanced.

A landmark report from the National Academies of Sciences reviewed hundreds of peer-reviewed studies and found strong evidence supporting the use of cannabis-derived compounds for:
• Chronic pain
• Chemotherapy-related nausea and vomiting
• Muscle spasticity associated with multiple sclerosis

The report also identified evidence for improving sleep disturbances, particularly when linked to pain or neurological conditions.

For many other health conditions, evidence remains limited or insufficient — not necessarily because these compounds don’t work, but because high-quality human trials are still developing. Researchers consistently emphasise that outcomes depend on dosage, formulation, individual biology, and proper medical supervision.

Importantly, gaps remain in long-term safety data, especially regarding frequent or unsupervised use. The scientific consensus supports targeted, evidence-based medical applications — not broad or universal claims.

As research advances, scientists are continuing to explore how specific cannabis compounds interact with the body’s nervous, immune, and pain-regulation systems to better guide clinical practice.

Science evolves — and responsible conversations should evolve with it.

Before cannabis became political, it became chemical.Dr. Raphael Mechoulam — widely regarded as the pioneer of modern ca...
22/02/2026

Before cannabis became political, it became chemical.

Dr. Raphael Mechoulam — widely regarded as the pioneer of modern cannabinoid science — helped transform cannabis from folklore into pharmacology.

In 1964–1965, Mechoulam and colleagues successfully isolated and synthesized Δ9-tetrahydrocannabinol (THC), identifying it as the primary psychoactive constituent of cannabis (Mechoulam & Gaoni, 1965, Journal of the American Chemical Society).

That discovery changed everything.
For the first time, scientists could study cannabis at the molecular level.
But the real breakthrough came later.
As researchers investigated how THC worked, they uncovered something remarkable: the human body already produces its own cannabis-like molecules — now known as endocannabinoids.

This led to the discovery of the endocannabinoid system (ECS) — a widespread biological signaling network present throughout the brain, nervous system, immune cells, and peripheral tissues (Di Marzo & Piscitelli, 2015, Neurotherapeutics).
The ECS helps regulate:
• Pain perception
• Mood and emotional balance
• Appetite and metabolism
• Memory and learning
• Stress response
• Immune and inflammatory activity

In other words, cannabis didn’t create a new pathway in the body.

It revealed one that was already there.
Mechoulam’s work shifted the narrative from myth to mechanism. Cannabis was no longer just a plant — it became a gateway to understanding one of the body’s most important homeostatic control systems.
Today, the endocannabinoid system is recognized as a central modulator of physiological balance, with implications across neurology, immunology, psychiatry, and pain medicine.

This wasn’t advocacy.
It was chemistry.
And it reshaped modern medical science.

🇦🇫🇵🇰 In the rugged highlands where Afghanistan meets Pakistan, cannabis adapted to altitude, cold nights, and unforgivin...
21/02/2026

🇦🇫🇵🇰 In the rugged highlands where Afghanistan meets Pakistan, cannabis adapted to altitude, cold nights, and unforgiving terrain.

Hindu Kush refers to traditional landrace cannabis populations native to the Hindu Kush mountain range, spanning eastern Afghanistan and northern Pakistan. Shaped by high elevation, arid soils, intense UV exposure, and dramatic temperature swings, these plants evolved for resilience rather than refinement.

Unlike heavily hash-selected Afghan lines, broader Hindu Kush landraces often express a slightly taller, more open structure with longer internodal spacing and less uniform branching. While still indica-dominant in morphology — with broad leaflets and sturdy stems — plants can appear leaner and more variable across phenotypes.

Flowers are resin-rich but typically less perfectly compact than modern commercial indicas. Calyx stacking is natural and sometimes slightly looser, reflecting regional diversity rather than modern stabilisation.

Colouration ranges from deep forest green to olive tones, with occasional bluish or purple hues emerging during cold mountain nights. Resin glands often give the buds a dusty, sandy appearance — a hallmark of traditional hash-producing cultivars from the region.

Aromatically, Hindu Kush expresses earthy and woody foundations layered with notes of pine, spice, subtle floral tones, and occasional sweet hash-like depth. The terpene profile commonly leans toward myrcene, pinene, and caryophyllene dominance.

As one of the foundational indica gene pools, Hindu Kush landraces contributed significantly to the development of modern indica cultivars worldwide — while still representing a genetically diverse mountain population shaped by environment, not commercial breeding.

Some genetics aren’t created — they’re forged by geography. 🌱

Cannabis isn’t unique because it’s controversial.It’s unique because of its chemistry.Dr. Ethan Russo — neurologist and ...
19/02/2026

Cannabis isn’t unique because it’s controversial.

It’s unique because of its chemistry.
Dr. Ethan Russo — neurologist and one of the leading researchers in cannabinoid science — has repeatedly emphasised that cannabis stands apart from most medicinal plants due to its extraordinary chemical diversity.

The plant contains:
• Over 100 identified cannabinoids
• Dozens of terpenes
• Multiple flavonoids
• Other biologically active compounds

These compounds interact with the body’s endocannabinoid system (ECS) — a regulatory network involved in pain modulation, inflammation, mood, immune function, and neurological balance.

Unlike single-molecule pharmaceuticals that target one receptor or pathway, cannabis compounds can influence multiple signaling systems at once.

In 2011, Russo helped formalise what’s known as the “entourage effect” — the idea that cannabinoids and terpenes may work synergistically, producing broader therapeutic effects together than when isolated (Russo, 2011, British Journal of Pharmacology).

Earlier, in 2004, he proposed the concept of Clinical Endocannabinoid Deficiency (CECD) — suggesting that certain treatment-resistant conditions like migraine, fibromyalgia, and IBS may involve dysregulation of the endocannabinoid system (Russo, 2004, Neuro Endocrinology Letters).

Importantly, Russo has consistently argued for something often missing from the conversation:
Not hype.
Not stigma.
But rigorous science.

He stresses that cannabis should be treated as a medical tool — requiring proper study, thoughtful dosing, and clinical oversight.
The conversation isn’t about miracle cures.
It’s about understanding a complex plant interacting with a complex biological system.

And that’s where the real science begins.

🇲🇦 In the mountains of northern Morocco, cannabis became something else entirely.Rif cannabis developed over generations...
18/02/2026

🇲🇦 In the mountains of northern Morocco, cannabis became something else entirely.

Rif cannabis developed over generations in arid, high-altitude conditions. The backbone of this region is Beldia, “the local one.”

Compact, sun-adapted, and resin-focused, Beldia sustained traditional kif culture for generations.

Built for the Rif

An early-flowering landrace adapted to the region’s latitude and short season, Beldia remains photoperiod-responsive but initiates flowering earlier than many equatorial types.

• Compact structure, typically 1–1.5m
• Narrow leaflets and drought-adapted morphology
• Selected for resin, not dense floral mass

Instead of large showpiece flowers, it produces smaller, airy buds rich in trichomes — ideal for dry-sift hash.

This plant wasn’t bred for bag appeal.
It was selected for resin.

Traditional Rif Resin Profile
Woody. Spiced. Cedar-like. Leathered. Honeyed. Earthy and nutty.
Less fruit-forward — more herbal, rustic, incense-like.

The Shift
In recent decades, many farmers adopted higher-yielding hybrid stock to increase output and THC levels. As a result, relatively pure Beldia populations have declined, now preserved mainly by traditionalists and conservationists.

The image reflects traditional Rif fields — compact Beldia dominant, alongside slightly taller regional phenotypes shaped by local selection and later hybrid influence.

The Rif reminds us: cannabis heritage isn’t hype.
It’s adaptation. Resin culture. Preservation. 🌱

Greed rewrote the narrative.
It silenced a plant that has clothed, healed, built, nourished, and sustained civilisations...
17/02/2026

Greed rewrote the narrative.

It silenced a plant that has clothed, healed, built, nourished, and sustained civilisations for thousands of years.

But truth has a way of resurfacing.

Through education, we unlearn the misinformation.
Through ingenuity, we rediscover its potential.
Through generosity, we share knowledge instead of hoarding it.
Through collaboration, we rebuild what was suppressed.

This isn’t just about a plant.

It’s about reclaiming wisdom, restoring balance, and choosing progress over profit-driven fear.

The comeback is rooted in awareness. 🌱

Before prohibition, cannabis wasn’t controversial — it was clinical.From the mid-1800s to the 1930s, cannabis extracts w...
16/02/2026

Before prohibition, cannabis wasn’t controversial — it was clinical.

From the mid-1800s to the 1930s, cannabis extracts were listed in the U.S. Pharmacopeia and prescribed by physicians across America and Europe.

Doctors used it for a variety of conditions such as:
• Chronic pain
• Migraine
• Insomnia
• Muscle spasms
• Menstrual cramps
• Anxiety
• Epilepsy
• Digestive disorders

It was sold by major pharmaceutical companies. It sat on pharmacy shelves. It was medicine.

So what changed?

Not science.

In the 1930s, political pressure, racialised propaganda, and industrial interests fueled a moral panic. The Ma*****na Tax Act of 1937 effectively criminalised cannabis through regulation and taxation. Research slowed. Medical access disappeared. Public perception shifted from “pharmacy extract” to “dangerous narcotic.”

Then in 1970, it was placed in Schedule I — defined as having “no accepted medical use” — despite over a century of documented therapeutic use.

Policy reshaped perception.

Today, modern research is rediscovering what 19th-century physicians already observed: cannabinoids interact with the body’s endocannabinoid system to regulate pain, mood, inflammation, and neurological function.

This isn’t about hype.
It’s about historical amnesia.

Understanding where cannabis stood before prohibition forces a bigger question:

How many other truths have been legislated out of memory?

🇹🇭 Long before modern hybrids, there was Thai.Thai landrace cannabis originates from Thailand and surrounding regions, w...
15/02/2026

🇹🇭 Long before modern hybrids, there was Thai.

Thai landrace cannabis originates from Thailand and surrounding regions, where it evolved naturally in hot, humid, tropical environments. These plants are known for their towering height, open structure, and slender, willow-like appearance — botanical adaptations that allowed them to thrive in monsoon climates.

Characteristically light to lime green, Thai landraces feature narrow leaves and airy, wispy buds, a structure designed to maximize airflow and prevent mould during flowering periods that can last 14 to 20 weeks. While most are green, specific Highland varieties and Purple Thai expressions display deep purple or red hues due to anthocyanin production in cooler mountain nights.

Beyond their structure, the true “magic” of Thai genetics lies in a rare terpene profile that is hard to find in today’s poly-hybrids. While modern street w**d is often heavy in Myrcene, true Thai is often dominated by Terpinolene, Ocimene, and Limonene.
This creates a complex, “old-school” aromatic signature:

🥭 Myrcene & Terpinolene: Sweet tropical fruit notes like mango and papaya.
🌲 Pinene & Ocimene: Sharp citrus, fresh pine, and floral woodiness.
☕ Bisabolol: The delicate floral depth found in the legendary Chocolate Thai and Highland phenotypes.

For the real genetic nerds: Recent lab analysis of the ‘Hang Krarok’ (Squirrel Tail) variety even revealed high levels of p-Cymenene, a rare molecule that sets these ancestral genetics apart from anything in a modern dispensary.

As true landraces, Thai varieties weren’t bred for speed; they were forged by environment and tradition, preserving the “electric” genetics that shaped global cannabis culture for decades.

To understand where we’re going, we have to look back to where it grew wild. 🌱

Nepalese Temple BallsBefore prohibition rewrote the narrative, Nepalese temple balls were part of a long-standing cultur...
14/02/2026

Nepalese Temple Balls

Before prohibition rewrote the narrative, Nepalese temple balls were part of a long-standing cultural and artisanal tradition rooted in place, climate, and human touch.

Hand-rubbed from living resin, they were shaped slowly — by warmth, time, and repeated contact — not by machines or shortcuts.

In the late 1960s and early 1970s, these hand-formed spheres traveled far beyond the Himalayan foothills. Moving from Nepal to Europe and North America, temple balls became quiet ambassadors of an ancient craft during a brief window when borders were porous and curiosity outweighed control. For many, they were a first encounter with cannabis as something made, not manufactured.

What’s often lost in the retelling is the labor behind them: hours of work, seasonal knowledge, and techniques passed hand to hand rather than written down. Their form reflected environment as much as intention — altitude, temperature, resin, and patience all played a role.

This piece revisits that moment in time — not to romanticise it, but to honor origin, process, and the hands that shaped it long before the story was interrupted.

A compound best known from “magic mushrooms” is showing serious medical promise.Researchers at NYU Grossman School of Me...
13/02/2026

A compound best known from “magic mushrooms” is showing serious medical promise.

Researchers at NYU Grossman School of Medicine studied psilocybin-assisted therapy in people facing life-threatening cancer diagnoses. When combined with structured, guided psychotherapy, one or a small number of sessions produced substantial reductions in anxiety, depression, and existential distress.

Follow-up studies months to years later found that many participants continued to report lasting psychological benefits. Most described the experience as deeply meaningful or spiritually significant, often changing how they related to fear, illness, and mortality.

Important context:
• This is clinical therapy — not casual or recreational use
• Sessions are supervised, structured, and paired with psychotherapy
• It is not a cure for cancer, but support for mental and emotional well-being

This research adds to growing evidence that certain psychedelic compounds, when used carefully in medical settings, may help people process end-of-life anxiety, grief, and psychological distress.

🇦🇫 In the harsh mountain ranges of Central Asia, one of the world’s purest indica landraces was shaped by survival.Afgha...
12/02/2026

🇦🇫 In the harsh mountain ranges of Central Asia, one of the world’s purest indica landraces was shaped by survival.

Afghan Kush is a true indica landrace originating from the Hindu Kush mountains of Afghanistan. Generations of extreme cold, dry air, high altitude UV exposure, and short growing seasons molded a plant built for resilience.

Unlike equatorial sativas, Afghan Kush evolved into a short, stocky structure with broad, dark forest-green leaves and tight internodal spacing — classic indica morphology. As temperatures drop toward harvest, phenotypes can display deep olive tones and occasional purple hues along the sugar leaves and bracts.

Its flowers are dense, compact, and heavily coated in milky-to-amber resin glands, often giving the buds a frosted appearance against their rich green backdrop — a natural adaptation that made it ideal for traditional hashish production.

Aromatically, it carries deep earthy notes layered with woody, spicy, and subtly sweet undertones — the unmistakable profile of classic mountain hash.

As a foundational indica landrace, Afghan Kush genetics became the backbone of countless modern indica cultivars and hybrids, while its original expression remains a powerful example of cannabis shaped by environment rather than modern breeding.

Some of the strongest genetics are forged under pressure. 🌱

If your joint hits different in winter, you’re not imagining it ❄️Cold air and low humidity can dry out your flower and ...
11/02/2026

If your joint hits different in winter, you’re not imagining it ❄️

Cold air and low humidity can dry out your flower and paper. Add wind, and the cherry loses heat faster — which can mean uneven burns, harsher smoke, and more relights.

Winter conditions really do change how a joint smokes — especially outdoors.

Stay lit. Just maybe not in a snowstorm.

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