28/11/2025
Alzheimer's disease and cognitive function.
Sage definition: "Profoundly wise".
Ongoing research suggests that sage (Salvia officinalis) enhances neuroprotective effects in Alzheimer's disease and cognitive function via a variety of mechanisms.
Similar to the medication donepezil, constituents in sage (such as rosmarinic acid) are able to increase the transmitter substance acetylcholine at nerve synapses by inhibiting the enzyme beta-secretase 1 (BACE1).
Inhibition of this enzyme also reduces synthesis of amyloid-beta plaques seen in Alzheimer's disease.
Furthermore, various constituents in sage reduce oxidative damage in neurons by up-regulating antioxidant genes.
This supports one of the many age-old traditional uses of sage. As far back as 1826, Culpeper described sage as ".... of excellent use to help the memory, warming and quickening the senses".
Herbalists rarely give single herbs, however. Instead, we follow the traditional practice of combining appropriate herbs, tailored to the individual; not all herbs are effective, or indeed safe, for all people. In addition, frequently herbs must be combined in a way which will not affect orthodox medications already being taken. It is this combining of relevant herbs which increases efficacy in that individual, for example, by one herb facilitating the sufficient absorption of another.
https://www.sciencedirect.com/science/article/pii/S1756464625001859