31/12/2025
Stay safe and well in times of celebrations.
This could help understanding of reactions to alcohol, as well as some other substances, particularly for any of those who generally have lower blood pressure.
“One glass of champagne and I’m on the floor.” 🥂😵
Before you toast tonight, it helps to understand why alcohol can affect people with EDS, POTS, and Mast Cell Activation symptoms differently than others.
1️⃣ Alcohol & Blood Pressure / POTS
Alcohol is a vasodilator — it causes blood vessels to relax and widen. This effect can lower blood pressure in anyone, but in people with Postural Orthostatic Tachycardia Syndrome (POTS) and similar dysautonomias, this can be more noticeable. In POTS, the autonomic nervous system already struggles to maintain blood pressure when upright, which can lead to lightheadedness, rapid heart rate, and fainting even without alcohol. Alcohol’s vasodilation can exacerbate this by encouraging blood to pool in the lower body and reducing effective blood return to the heart.
➡️ This is why some people with POTS feel dizzy, weak, or like they “crash” after drinking.
2️⃣ Alcohol & Mast Cell Activity / Histamine
Alcoholic beverages — especially wine, champagne, beer, and fermented drinks — contain histamine and other biogenic amines. For people with Mast Cell Activation Syndrome (MCAS) or histamine intolerance, this can trigger symptoms such as flushing, itching, headaches, nasal congestion, and digestive upset.
However, not everyone with EDS has MCAS, and not everyone with MCAS reacts to histamine in alcohol the same way — but the connection between histamine in foods/beverages and symptoms is recognized in clinical practice.
So what’s really happening?
• POTS + alcohol → increased vasodilation + pooling may worsen orthostatic symptoms.
• MCAS/histamine sensitivity + alcohol → histamine in drinks may trigger allergic-like symptoms.
Everyone’s body is different — some people tolerate small amounts of alcohol fine, others find it blows their symptoms out of proportion.
Tips if you choose to drink
• Hydrate well beforehand and afterward — dehydration worsens orthostatic intolerance.
• Replace electrolytes (e.g., water with sodium or electrolyte drinks) — this can help blood volume and pressure.
• Consider low-histamine drinks (e.g., distilled spirits mixed with nonhistamine mixers) if histamine reactions are a concern.
• And of course, it’s always okay to choose mocktails! 🥤
👇 Who else is toasting with water and electrolytes tonight?