15/01/2024
The matrix system [essential base tissue] is a functional unit consisting of the capillary bed, the connective tissue cells and the autonomic nerve endings.
The area of activity consists of the extracellular fluid and the extracellular spaces. The lymphatics are connected to this system.
It is part of all inflammatory and immune processes.
The very existence of all organ cells depends upon the intact functioning of the system. Disease results from dysfunction of this system. The extra cellular matrix system reacts either locally of generally. Chronic disease is maintained by [1] stress factors and [2] reaction processes of the matrix system.
A cell cannot be considered by itself without taking its environment into account.
Bechamp’s work shows that the cause of disease lies within the blood, cells and tissue fluids. Lipton says the intra and extra-cellular fluids are highly significant in genetic changes [‘it’s the environment’ that affects cells].
The organisation of the extracellular matrix can be seen in the connective and supporting tissues including the blood. The matrix is bound by sugar-protein polymers in a variety of forms with protein and lipid binding forms of intercellular substances. Proteoglycans [PG] predominate EG collagen, elastin etc., within the matrix. The proteoglycans, glycos-aminoglycans and glycoproteins form a molecular sieve through which the entire metabolism of the capillaries must pe*****te. The pore size is determined by the concentration of proteoglycans in the tissue compartment, the PG molecular weight, the electrolytes and the ph. The negative charge on the PG has a crucial effect upon fluid movement and guarantee ionic and osmotic homeostasis.
Connective tissue has more than a mere supporting and filling function; it carries out nutritive and regenerative tasks in the service of specific organ function, as well as being a mediator of circulatory and nerve functions. The connective tissue substance is a vital binding substance. Nerves and blood vessels do not come into direct contact with functioning cells but the connective tissue facilitates support that allows nerve impulses and nutrition to move throughout the body. Only the connective tissue has direct contact with all bodily parts.
Parenchymal cells require nutrition via the blood; in turn involving the capillaries and nerves. Parenchyma has a role in transmission of nutrients throughout their canaliculi [channels]. Lymphatic vessels are found everywhere throughout the connective tissue.
The connections between the cell and the capillary bed is through the extracellular matrix. Disruptions to the matrix are the cause of disease.
Connective tissue cannot be considered separately from the capillary vessels, blood and blood formation. Specific diseases are misleading as they only consider only one of the components of the connective tissues – either the fibres or the fluids. The cell is the central point in the connective tissue. The cell and its reactions are the visible expressions of the ANS activity and the reactivity of the connective tissue.
Tissue is thermodynamic with open energy throughout the cells; this energetic exchange allows nutrition to spread through the body. Minerals spread nutrition throughout the entire system.
The extracellular matrix is connected into the endocrine gland system through the capillaries and to the CNS by peripheral autonomic nerve fibres which end blindly in the extracellular matrix. Since both systems are connected to each other in the brain stem; the higher regulatory centres can be influenced through the extracellular matrix. Capillaries, nerves and connective tissue cells that regulate the ground substance can reciprocally be influenced through wandering tissue cells – macrophages, leucocytes and mast cells. The same capillaries, nerves and connective tissue cells can be influenced through information from released cell products EG cytokines, prostaglandins, proteases etc. This creates a vast interlinked humoral system. The advantage of this system lies in a considerable increase in adaptability that cannot be achieved by adding the single properties of the components.
Extracted from ‘Herbal Medicine Keys to Physiomedicalism including Pharmacopoeia’. 3rd Ed. 2023. Christopher Menzies-Trull. Available from
Staffordshire herbalist using natural treatments and nature’s ability to heal; employing methods such as Herbal Medicine, Nutrition, Hydrotherapy, Flower...