NIHR Nottingham Biomedical Research Centre - GI & Liver Disorders

26/04/2023

Hello! We are looking for healthy adult participants to join our study on the effect of dietary fibre on the bowel. A disturbance allowance will be provided for completion of the study. More information can be found below👇

As part of the MRC Experimental Medicine Project ENERGISE, we are running a study in collaboration with Department of Food Science (Nottingham) and the Quadram Institute (Norwich). We are looking to recruit healthy participants aged 18+ to join our study on the effect of fibre drinks on the bowel. Our study is looking to better understand how certain types of fibres may impact gut health and better understanding why some individuals have better tolerance for fibre than others.

We are currently inviting inquiries for healthy participants to join our study group. If participants are happy to consent to the study, we will invite participants to a screening visit where we will provide 2 baked muffins containing blue food colouring. We aim to assess how long it takes for food to pass through your gut by getting you to eat a muffin containing blue food dye and recording the time when your stool first shows the blue colour and texting our study mobile. We will also provide participants with a stool sample kit so they can provide a stool sample at their convenience ahead of the study days. We will also provide dietary guideline information to be adhered to ahead of the three study days.

Participants will be invited to three study days (at least 1 week apart). A study day would involve arriving fasted from the previous evening meal, consuming a drink containing a mixture of a fermentable fibre (Inulin) and one of three other fibres (psyllium, methyl cellulose or maltodextrin), and measuring the concentration of gases in your breath. We will monitor your breath concentrations for 6 hours on site and will provide participants with special bags which they can breathe into at home. We will provide participants with a standard lunch and another meal to prepare and consume in the evening.

Participants will be given a disturbance allowance for their time and contribution to the study. If you are interested in taking part, or know someone who may be interested in taking part, please contact Joshua Reid (Joshua.reid@nottingham.ac.uk) and Alaa Alhasani (alyaa11@exmail.nottingham.ac.uk) and ask for more information to the COCOA2 study.

18/10/2022

Just out!!

Campylobacter enteritis produces profound depletion of the colonic microbiota which can shift the microbiota past a “tipping point” of no return, resulting in long lasting post infection irritable bowel syndrome.

👉Read now: https://bit.ly/3yJO24T

08/06/2022

Good day everyone!

We are looking for 18-65 years-old volunteers with non-alcoholic fatty liver disease (NAFLD) for our current LGI study. More info at
https://nddcbru.org.uk/diet-and-non-alcoholic-fatty-liver-disease-nafld-study

Inconvenience allowance available. All diets will be supplied for 4 weeks in total. Please note all the study visits are in Nottingham!

27/04/2022

We are looking for volunteers with occasional constipation for our current MRI study of a common laxative, more info at

https://nddcbru.org.uk/study/mri-assessment-of-mode-of-action-of-bisacodyl-single-dose-mods

Please note all the study visits are in Nottingham !

10/03/2022

Millions of people in the UK have Irritable Bowel Syndrome (IBS). But those with IBS have never been asked what research they want to see into their condition... until now!🤩
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Guts UK is proud to announce that with the British Society of Gastroenterology, our first IBS Priority Setting Partnership survey is live. Now is your opportunity to tell us what IBS questions you want research to answer! - https://www.surveymonkey.co.uk/r/PSP_IBS
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It's time we decided the future of IBS research together - patients, healthcare professionals, families and carers alike. Please share far and wide.
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💚https://www.surveymonkey.co.uk/r/PSP_IBS

01/03/2022

We made a podcast with our NIHR BRC media specialist to talk about our MRI work with the Birmingham dynamic colon model (the DCM). Link here https://t.co/L8sG6DEVy3

17/01/2022

Prof Guru Aithal was invited to write a blog post '50 at 50: Myth, Medicine and the Marginalised'

‘Simpler history is constructed by the victors. Someone like me figured in their stories. Life can be otherwise.’ Abdulrazak Gurnah Nobel Prize for Literature 2021 A sunny morning in May 2001, I was having breakfast in a hotel in Atlanta, attending the Digestive Diseases Week, Annual meeting of ...

10/12/2021

We are looking for volunteers with occasional constipation for our current MRI study of a common laxative, more info at https://www.nddcbru.org.uk/study/mri-assessment-of-mode-of-action-of-bisacodyl-single-dose-mods
Please note all the study visits are in Nottingham !

18/11/2021

Listen to the latest episode of The Clinical Research Podcast - 'How cultural awareness should change clinical research - and researchers' with Professor Guru Aithal:
https://anchor.fm/nottmresearch/episodes/How-cultural-awareness-should-change-clinical-research---and-researchers-e1a696m
Professor Aithal talks to Matt Hurst from Research & Innovation about how science and his own personal experiences have shaped his views on why every researcher needs to build trust with ethnic communities.

This week our guest is Professor Guru Aithal, Deputy Director of the NIHR Nottingham Biomedical Research Centre and a world-leading researcher in gastrointestinal and liver disorders. Professor Aithal talks to Matt Hurst from Research & Innovation about how science and his own personal experiences h...

19/10/2021

Meshari’s systematic review and meta-analysis of MRI accuracy for detection of colonic inflammation in IBD published today open access in Diagnostics https://doi.org/10.3390/diagnostics11101926 ! Well done Meshari !!!

22/09/2021

Dr Giles Major featured in Channel 5 documentary 'How to Stop your IBS' 22mins in

12/08/2021

Listen to The Clinical Research Podcast featuring our BRC team:
Professor Guru Aithal, Professor Penny Gowland, Professor Neil Guha & Dr Gordon Moran.

Clinical research is very much about collaboration, which means it can often also be very much about lots of organisations, with lots of initials. We try not to burrow too deeply into that particular rabbit hole unless we really have to, but for this episode - we really have to. Rather than people o...