10/09/2025
A recent study revealed that dandelion root extract can induce cancer cell su***de in over 90% of colon cancer cells within just 48 hours.
Dandelion root extract (DRE) triggers apoptosis (programmed cell death) in aggressive cancer cell lines such as colon cancer, melanoma and leukemia with minimal to no effect on healthy cells.
DRE targets the altered metabolic pathways within cancer cells. Research shows DRE disrupts the mitochondrial membrane potential and increases Reactive Oxygen Species (ROS) levels in cancer cells’ mitochondria.
Studies indicate DRE can affect specific signaling pathways involved in cancer cells proliferation and survival. For instance, it may activate the extrinsic pathway of apoptoses, involving caspase-8 activation.
In breast cancer, DRE affects P13/AKT signaling pathways involved by inhibiting the expression of choline kinase a (CHKA).
DRE can also influence the expression of genes associated with cell death and survival. Some studies show that DRE treatment led to the upregulation of pro-apoptotic genes in certain cancer cell lines.
PMID: 27564258
