04/11/2025
At last a mouthwash that won't take the roof of your mouth off! 😉
Contemporary reviews and consensus statements now frame oral health as integral to overall health across the lifespan, with credible links to cardiovascular disease, diabetes, adverse pregnancy outcomes, pneumonia, rheumatoid arthritis, chronic kidney disease, dementia, and even some cancers, especially colon. While the evidence comes from observational studies (association not causation), the associations are generally strong and causality signals are strengthening through Mendelian randomisation, intervention trials and mechanistic data, but do vary by condition. Guideline/consensus bodies now explicitly recommend medical-dental co-management for cardiometabolic risk.
Oral dysbiosis/infection from bacteria appears to be the causal link, driving low-grade systemic inflammation and endotoxaemia, recurrent bacteraemia, immune priming, molecular mimicry and microbiome translocation (oral–gut axis).
In this context, the finding that a Chinese licorice root (Glycyrrhiza uralensis) mouthwash slashed plaque and gum-inflammation scores by around 40–50 % in just five days has implications well beyond just oral health. The herb wiped out several major periodontal pathogens, including Porphyromonas gingivalis and Treponema denticol, and substantially outperformed the speed of improvement seen in green-tea or conventional mouthwash trials. These results spotlight licorice as a fast-acting, natural antimicrobial for gum and oral health.
This was a randomised, double blind, controlled study conducted on 60 patients who visited a dental clinic in South Korea. For the periodontal clinical parameters, the O'Leary index, plaque index (PI), gingival index (GI), and periodontal-disease-related bacteria in subgingival plaques were examined (at baseline and after 5 days of treatment).
The O’Leary index decreased by 40.43%, the PI decreased by 51.29% and GI decreased by 44%, In terms of bacterial outcomes, the licorice gargle produced antibacterial effects on both Gram-positive and Gram-negative pathogens involved in periodontal disease.
Active treatment was 15 mL of the licorice solution applied once a day as both a gargle and mouthwash for 30 seconds for 5 days. This was prepared as follows: dried Glycyrrhiza uralensis root was extracted (70 % ethanol), filtered, concentrated and freeze-dried into a powder. This concentrated extract was then dissolved in distilled water to make a 0.5 % w/v mouthwash (the test solution). No eating, drinking, or other oral hygiene procedures were allowed for 30 minutes after use to maximise mucosal contact and antimicrobial exposure.
Given the phytochemical similarities, it is highly likely that European licorice (Glycyrrhiza glabra) will have the same benefit. I recommend a 1 in 10 dilution of a high glycyrrhizin licorice 1:1 extract. This should be considerably stronger than the test mouthwash/gargle used in the trial.
For more information see: https://pubmed.ncbi.nlm.nih.gov/40413479/
