Southampton Paediatric Inflammatory Bowel Disease Research

10/03/2020

Our new paper on monogenic causes of inflammatory bowel disease-

. METHODS: Whole exome sequencing was performed on patients with pediatric-onset disease. Variants fulfilling the American College of Medical Genetics criteria as “pathogenic” or “likely pathogenic” were assessed against phenotype at diagnosis and follow-up. Individual patient variants were ...

30/03/2019

A very exciting study on personalising therapy using a clinical and multi-omic approach. The results from the PROTECT study, published in the The Lancet

Read the comment from the team Southampton Children's IBD Group by Dr James Ashton and Prof Mark Beattie

Children presenting with inflammatory bowel disease (IBD) typically have a moderate-to-severe disease phenotype, accompanied by frequent complications and challenging management.1 However, substantial differences exist between patients, with some having relatively quiescent disease and others requir...

07/02/2019

Exclusive enteral nutrition in Crohn's disease: Evidence and practicalities, from Mark Beattie Southampton Children's IBD Group

Published in the latest issue of Clinical Nutrition ELS Nutrition

Exclusive enteral nutrition (EEN) is the first line therapy for paediatric Crohn's disease, providing a complete nutritional feed whilst simultaneously inducing remission in up to 80% of cases. The effect of EEN on systemic/local intestinal immune function and subsequent inflammation (including barr...

18/01/2019

The future of treatment in paediatric IBD?

Our latest review on 'Personalising medicine in inflammatory bowel disease—current and future perspectives'

18/01/2019

Our recent work- Increased prevalence of anti‐TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood, published in APT.

https://onlinelibrary.wiley.com/doi/10.1111/apt.15094

Coverage in medical news https://www.healio.com/gastroenterology/inflammatory-bowel-disease/news/online/%7B94ea6506-1a54-451d-9172-d407d5108791%7D/rise-of-anti-tnf-means-less-resections-in-pediatric-ibd

Alimentary Pharmacology & Therapeutics Volume 0, Issue 0 ORIGINAL ARTICLE Free Access Increased prevalence of anti‐TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood James J. Ashton http://orcid.org/0000-0003-0348-8198 Departme...

10/01/2019

Anti-TNF therapy is associated with a decreased rate of surgical resection during childhood in . Work from the Southampton IBD research team.

Our latest publication showing that anti-TNF therapy is associated with reduced need for surgery in childhood, however it is likely to delay surgery rather than avoid completely.

Alimentary Pharmacology & Therapeutics Volume 0, Issue 0 ORIGINAL ARTICLE Free Access Increased prevalence of anti‐TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood James J. Ashton http://orcid.org/0000-0003-0348-8198 Departme...

08/01/2019

Our most recent publication in IBD journal on blood tests at diagnosis. Up to 10% of children with IBD present to hospital with all normal blood tests

AbstractBackground. Pediatric inflammatory bowel disease (PIBD) is associated with a diagnostic delay. Blood tests are a routine part of the work-up in childre