HempKnot

09/11/2025

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NEWS You Might Have Missed

nz cancer.community
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09/11/2025

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CBGA’s role in thyroid health runs deeper than most realize. The thyroid gland isn’t just a hormone factory – it’s a precision instrument guided by the Master Regulator, the Endocannabinoid System (ECS). When that system’s tone is off, thyroid signaling often follows. Fatigue, weight shifts, mood swings, or temperature sensitivity can all trace back to miscommunication between the ECS and the hypothalamic-pituitary-thyroid (HPT) axis.

A 2018 review titled The Endocannabinoid System and Thyroid Hormones: Implications for Energy Balance detailed how endocannabinoids like anandamide influence thyroid hormone release through CB1 receptors in the hypothalamus and pituitary. When those receptors are over- or under-stimulated, thyroid output can fluctuate, resulting in either hypo- or hyper-like symptoms.

The ECS acts as the body’s thermostat for hormones, metabolism, and temperature regulation.

CBGA, the acidic “mother” cannabinoid, adds a unique layer of support. Unlike THC or CBD, it doesn’t overstimulate CB1 or CB2 receptors. Instead, it modulates them indirectly and interacts with PPAR-alpha receptors – key regulators of lipid metabolism and inflammation inside thyroid tissue.

A 2021 study titled PPAR Activation by Cannabigerolic Acid: Implications for Metabolic Disorders demonstrated that CBGA’s interaction with these receptors helped restore lipid and glucose balance in cell models. Since thyroid health is deeply tied to metabolic stability, this connection matters.

Chronic inflammation, oxidative stress, and immune overactivity are common triggers for thyroid dysfunction. CBGA’s antioxidant and anti-inflammatory effects protect thyroid cells from the oxidative strain that can lead to autoimmune issues like Hashimoto’s or Graves’. By reducing reactive oxygen species and supporting mitochondrial health, CBGA helps the gland maintain its rhythm without overworking.

So while traditional medicine often treats thyroid symptoms at the hormonal level, CBGA works one step upstream – helping the ECS coordinate thyroid signaling from the inside out. Balance the Master Regulator, and hormone balance follows.

-Mike Robinson, The Researcher OG

09/11/2025

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CBG – cannabigerol – is one of the most overlooked yet powerful cannabinoids for bladder health. While most people are familiar with it for its role in mood balance or gut function, research indicates that it has a significant anti-inflammatory effect on the urinary system, particularly in conditions where pain, urgency, or inflammation prevail. The bladder's walls are packed with cannabinoid receptors, meaning it's directly wired to the Master Regulator – the Endocannabinoid System (ECS).

When those receptors are activated properly, the bladder can relax, heal, and function normally again. A 2015 study titled "Cannabinoid Receptors and the Urinary Bladder," published in Nature Reviews Urology, highlighted how CB1 and CB2 receptors influence bladder contractility and pain sensitivity.

When these receptors are underactive, inflammation flares, muscle tone increases, and individuals experience symptoms similar to those of interstitial cystitis or an overactive bladder. CBG's mild affinity for both receptors makes it ideal – it doesn't overstimulate, it restores tone.

CBG also works through other cellular pathways. It's known to inhibit inflammatory enzymes, such as COX-2, and reduce nitric oxide production, both of which contribute to bladder wall irritation and pelvic pain.

A 2019 paper titled "Cannabigerol Exerts Anti-Inflammatory Effects in Bladder Epithelium via PPAR Activation" demonstrated how CBG protected epithelial cells from cytokine-induced damage while promoting barrier repair. This is crucial because chronic inflammation weakens the bladder lining, leading to pain, frequency, and sometimes infection.

Through the ECS, CBG calms nerve overactivity in the bladder's detrusor muscle – the same muscle responsible for contractions during urination. By lowering excitatory signaling, it helps reduce urgency and nighttime urination, allowing the bladder to rest and recover. The effect isn't sedation – it's signal stabilization.

When the ECS is balanced, the bladder communicates properly with the nervous system, keeping inflammation in check and maintaining smooth function. CBG restores that balance by targeting both the neural and immune components of bladder health.
For anyone dealing with bladder pain, urgency, or inflammation, CBG represents more than symptom relief – it's molecular repair through the body's own regulatory system.
-Mike Robinson, The Researcher OG

09/11/2025

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CBGA is often called the “mother cannabinoid,” but what it really does is act like a molecular coach for your cells – especially the mitochondria, those tiny engines that power everything you do. Mitochondria make ATP, the fuel that keeps your body running, but they’re also sensitive to stress, toxins, and inflammation.

When they struggle, energy levels drop, oxidative stress increases, and disease risk rises. That’s where CBGA steps in. A 2021 study titled Cannabigerolic Acid Protects Mitochondrial Function and Reduces Oxidative Stress in Neuronal Cells showed that CBGA helps preserve mitochondrial membrane potential – the electrical charge that allows ATP to form efficiently.

When cells are under oxidative stress, CBGA reduces reactive oxygen species, assisting mitochondria to remain stable. Think of it like reinforcing the walls of an overworked factory before it burns out.

The Endocannabinoid System – the Master Regulator – oversees mitochondrial balance by managing calcium flow, metabolic rate, and redox state inside cells. CBGA supports that role by enhancing the body’s own endocannabinoid tone. It doesn’t just act on CB1 or CB2 receptors – it influences PPAR receptors and TRP channels, both of which control how mitochondria use oxygen and handle inflammation. The result is cleaner energy output and less cellular waste.

When mitochondria function properly, everything else follows – mood, metabolism, focus, and immune strength. But when they’re overloaded or underpowered, the ECS compensates by sending signals that can lead to fatigue, pain, or brain fog. CBGA’s antioxidant and bioenergetic effects help the Master Regulator restore communication between the nucleus and mitochondria, allowing cells to adapt instead of collapsing.

That’s why CBGA fits perfectly into the concept of ECS Balance Control – it’s not just about cannabinoids and receptors, it’s about how every cell produces, uses, and protects its own energy. By supporting mitochondrial function, CBGA helps maintain the internal rhythm that keeps life steady, one molecule of ATP at a time.

-Mike Robinson, The Researcher OG

08/11/2025

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🥛 H**p seeds: more protein than beef, more omega than fish.

The forgotten crop that could feed the future.
H**p protein is complete, clean, and sustainable — rich in all nine essential amino acids, packed with omega 3 & 6, and grown with a fraction of the water and land used by soy or meat.

It’s already fuelling livestock, athletes, and innovators building the next wave of functional foods.

💬 Would you use h**p protein daily if it was cheaper?

**pFoods **pNutrition **pWarehouse

07/11/2025

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Families face a stark reality: private prescriptions for cannabis can cost £500 a month and in some cases exceed £2,000 per month, while flower costs around £200–£400 for adults with chronic pain. This financial strain forces many to seek illegal alternatives.

The Need for Change

We must implement an NHS funding model to provide access to cannabis-based medicines for both children and adults with chronic health conditions. This would alleviate financial hardship and ensure equitable access based on clinical need.

Without NHS support, many patients are left with impossible choices, leading them to illegal options. The U.K. government must act now to provide the necessary support.

🔴 What You Can Do:

- Write to Your MP: https://endourpain.org/email-your-mp/
- Sign Our Petition: https://www.change.org/p/urgent-government-reimbursement-scheme-for-children-accessing-medicinal-cannabis-click-to
- Call for a Public Inquiry:https://openletter.earth/structural-impunity-in-the-dhsc-families-demand-answers-af6c8893

Together, we can ensure every patient has access to the medicines they need.

07/11/2025

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FACTS!
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news

05/11/2025

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Signal loss in the brain isn't just electrical – it's biochemical. In Parkinson's disease, neurons that produce dopamine slowly degenerate, breaking the rhythm between brain regions that control movement, mood, and memory. The tremors, stiffness, and fatigue people see on the surface are symptoms of deeper misfires.

Inside the brain, messages start to fade because The Master Regulator – the Endocannabinoid System – loses tone. When CB1 receptors along dopaminergic pathways weaken, the system can't properly modulate neurotransmitter release. The result is static in the body's communication lines, a neurological traffic jam where dopamine can't signal smoothly, and muscle control begins to slip.

A 2011 study titled "Endocannabinoid System as a Therapeutic Target in Parkinson's Disease" described how disrupted endocannabinoid signaling in the basal ganglia directly contributes to both motor and non-motor symptoms. Normally, endocannabinoids act like feedback moderators – when neurons fire too fast, they release compounds like anandamide to calm them down.

But in Parkinson's, this modulation fails. Anandamide levels often spike early, then crash, leaving receptors overstimulated or depleted. It's a cycle that accelerates neuron exhaustion.

Cannabinoids from the plant step in as biochemical translators. They help restore timing between synapses, slow neuroinflammation, and shield nerve cells from oxidative stress. More importantly, they can reawaken parts of The Master Regulator that have gone quiet. When those CB1 and CB2 receptors begin to function again, it's like reconnecting old wiring in a house – the lights flicker, then start to glow steady.

Parkinson's reminds us that brain balance depends on communication – not just dopamine alone, but the harmony between every signaling molecule the body makes.

-Mike Robinson, The Researcher OG

04/11/2025

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🇵🇱 H**p in Poland

For hundreds of years, h**p was a staple crop in rural Poland.
It provided strong fibre for clothing, rope, and traditional crafts, and today it’s finding new life in sustainable industries.

**p **pAroundTheWorld **pInPoland **pCulture **pCommunity

30/10/2025

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The military once used cannabis to protect soldiers from chemical weapons — but the research was buried.

In 1954, U.S. Army scientists discovered that cannabis protected nerve cells from damage caused by nerve agents like sarin and VX gas. Soldiers who were given cannabis extract in testing showed significantly reduced neurological damage when exposed to organophosphate toxins.

Instead of exploring this life-saving discovery, the research was classified and buried because:

✅ It proved cannabis had neuroprotective properties
✅ It threatened future pharmaceutical patents for nerve agent antidotes
✅ It didn’t fit the “cannabis is harmful to the brain” propaganda

Decades later, scientists rediscovered the same truth:
• In 1998, the U.S. government patented cannabinoids as neuroprotectants (Patent US6630507).
• That patent openly states cannabinoids can protect the brain from trauma, stroke, toxicity, and degenerative diseases.
• Yes — the same government that calls cannabis “dangerous” secretly owns a patent saying it protects your brain.

Ask yourself—
If cannabis can literally protect your brain from nerve damage and toxins…
why is it still treated like a crime instead of a cure?

30/10/2025

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CBGA initiates what can be called the neuro-lipid activation phase - the process that sets the brain and body’s communication systems in motion each morning. As the acidic precursor to all cannabinoids, CBGA acts like a biochemical starter switch. When taken early in the day, it stimulates the endocannabinoid network - The Master Regulator - to begin producing and mobilizing its own lipid messengers, primarily anandamide and 2-AG. These compounds are the body’s natural mood, energy, and balance modulators.

CBGA enhances the sensitivity and density of cannabinoid and related receptors, allowing endocannabinoids to bind more effectively. This activity synchronizes neuro-lipid signaling with mitochondrial output, creating a steady release of cellular energy and improved neurotransmitter flow. In the brain, it supports lipid-based synaptic remodeling, which sharpens focus, lifts cognitive function, and sets a calm but alert tone for the day.

On a systemic level, CBGA also influences AMPK and PPAR pathways, balancing fat metabolism and inflammation at their root. By converting stored lipids into usable cellular fuel, it helps transition the body from a state of rest and repair into one of movement and productivity.

In short, CBGA doesn’t just wake the mind - it aligns the body’s lipid and hormonal communication lines, launching the neuro-lipid activation phase that fuels focus, endurance, and emotional stability through The Master Regulator. -Mike Robinson, The Researcher OG

29/10/2025

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