HempKnot

10/12/2025

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Food for your health

08/12/2025

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Scoliosis changes the way the entire body moves. A curved spine shifts balance, twists soft tissue, and leaves muscles on one side overworking while the other side strains to keep up. That uneven pull creates inflammation, nerve irritation, and the deep muscle guarding that so many patients describe as a daily fight rather than a single symptom. Cannabinoids cannot straighten a spine, yet they help the Master Regulator guide the system back toward a calmer baseline. They assist the body in ways that improve mobility, reduce pain spikes, and soften the tension patterns that develop over the years with scoliosis.

A clear example appears in the study The Effectiveness of Cannabinoids in Chronic Pain Management published in 2021, which documented how cannabinoids interact with pain pathways and inflammatory responses. That research helps explain why THC, CBG, and CBD give patients with scoliosis meaningful support. THC acts on the perception side by interacting with CB1 receptors, which influence how the brain interprets pain signals. When nerves along the curve fire constantly, the brain becomes overwhelmed. THC reduces that noise, so movement doesn't feel like a threatening pain. Patients often feel a sense of space in their back again because the sharp peaks of discomfort begin to level off.

CBD steps in by easing the muscle guarding that scoliosis creates—the spine's asymmetry forces certain muscle groups to stay tight, which increases inflammation and fatigue. CBD interacts with receptors that regulate inflammatory cytokines and muscle tone. As the tissue relaxes, the patient moves with less resistance, and the constant tug of imbalance becomes more manageable.

CBG plays a complementary role by influencing CB2 and other receptor systems linked to structural inflammation and nerve irritation. Scoliosis creates pressure points where joints and ligaments flare. CBG helps settle that reaction so the burning and aching at those hinge points fade. It offers gentle neuromodulating support that stabilizes posture related pain.

Together, these cannabinoids give the Master Regulator the tools it needs to reorganize pain, tension, and inflammation. The curve remains, yet the patient gains relief that feels natural instead of forced.

-Mike Robinson, The Researcher OG

04/12/2025

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04/12/2025

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A cancer diagnosis presents immense challenges, especially when navigating the complex journey of treatment. Finding effective supportive care options is a priority for many on this path.

So, why is cannabis and h**p CBD an area of growing research interest?

The key lies in your body’s largest regulatory network: the Endocannabinoid System (ECS). This crucial system works to maintain overall biological balance (homeostasis), influencing functions like:
• Mood
• Sleep
• Appetite
• Pain management

The plant compounds (phytocannabinoids) found in cannabis and h**p are studied for their unique ability to interact with the ECS, offering a new perspective on how we approach supportive care.

Want to learn more about the science behind the ECS and the research surrounding cannabis in cancer care? Read the blog—links in the comment section! 💚

03/12/2025

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When we talk about ovarian cancer, we are looking at a disease driven by aggressive cell growth, disrupted metabolic flow, and a storm of inflammation that feeds the tumor microenvironment. THC and CBGa approach this landscape from two very different but beautifully complementary angles. THC binds to CB1 and CB2 receptors, thereby disrupting survival signaling in cancer cells.

It slows their spread, alters mitochondrial function, and drives malignant cells toward programmed cell death. CBGa does not rely on the classic receptors as much. Instead, it steps into the biochemical machinery that fuels abnormal growth. It disrupts energy production pathways that cancer cells depend on, reduces oxidative stress in surrounding tissues, and improves communication between immune cells trying to contain the disease.

This is not anecdotal. We have real evidence showing how cannabinoids interact with ovarian cancer biology. One key study that moved this conversation forward was Cannabinoids Induce Apoptosis in Ovarian Cancer Cells (2014). It showed how THC and related compounds promote apoptosis and reduce cell viability through receptor-driven and receptor-independent pathways.

That aligns with what I have seen in patients using a balanced profile that includes CBGa as a stabilizer. CBGa helps regulate metabolic tone in the tumor microenvironment, calming the inflammatory environment that cancer cells thrive in. THC then hits the internal switches that cancer cells fear most.

Ovarian cancer does not give patients much room for error. Protocols must be precise, and the ECS provides us with a window into how to design them. When the Master Regulator receives the right signals, the immune system becomes more coordinated, oxidative stress drops, and the tumor environment loses some of its advantage.

This is not a cure. It is a strategy that supports the body during an intense battle. THC and CBGa work best when the focus remains on restoring internal balance rather than chasing symptomatic relief. Patients who approach treatment this way often gain steadier energy, calmer inflammation, and better resilience through each phase of care.

Contact me for a consult or more information on this topic.

-Mike Robinson, The Researcher OG

01/12/2025

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30/11/2025

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27/11/2025

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When someone dealing with menstrual discomfort comes to me, I explain that most of the pain is created by inflammatory compounds called prostaglandins. These signals tell the uterus to contract and shed its lining. When those signals surge too high, the cramps become sharp, the back aches, mood pressure rises, and the patient feels like their whole system is running too hot. This is where the ECS, our Master Regulator, steps in to calm the nerves, ease inflammation, and keep the monthly rhythm steady.

CBD supports that process because it works on multiple pathways tied to menstrual pain. It helps reduce prostaglandin activity by inhibiting COX and LOX enzymes, thereby softening the intensity of the cramps. It also stabilizes serotonin signaling, and that matters because serotonin heavily influences uterine contractions, mood, and gut motility. When CBD nudges those pathways into balance, the entire experience becomes less overwhelming. It does not numb the body; it helps restore clarity, so the cycle does not feel like a tidal wave.

A key piece of evidence comes from Cannabidiol inhibits COX2 expression and prostaglandin production in human cells, 2013. That study provided scientific support for what many patients had already been reporting: that CBD eases menstrual discomfort by dialing down the inflammatory cascade at the cellular level. When the inflammatory tone drops, the cramping becomes less severe, and the system no longer overreacts to regular monthly changes.

CBD also helps with PMS because of its interactions with GABA and endocannabinoid tone. Many PMS symptoms are tied to fluctuating hormones that pull the nervous system in several directions at once. Anxiety spikes, irritability rises, and sleep becomes unpredictable. CBD supports the Master Regulator by calming those signals without sedation, so mood steadies and the patient feels less reactive to the stress that tends to build right before the cycle.

When someone pairs CBD with mindful hydration, magnesium intake, and steady use of plant-derived bioactives, the body often settles into a much smoother monthly rhythm. That is the beauty of supporting the Master Regulator. You do not force the cycle to change; you help the system regulate itself so pain does not dominate the month.

Truly, it's ECS Balance that's key. If you're interested in talking about that, reach out!

-Mike Robinson, The Researcher OG

26/11/2025

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When a patient comes in with chronic swelling or soreness that just will not quit, I start the story in the same place every time. Cellular breakdown is the match that lights the fire known as inflammation, and it is a fire our ECS, our Master Regulator, works hard to control. A cell under stress begins to leak signals that call in immune cells, and that rush creates heat, pressure, and irritation.

The body is trying to protect itself, but when this cycle does not slow down, the patient feels it in joints, nerves, and even mood. Our Master Regulator steps in to calm that storm by slowing excessive immune activity, guiding enzymes, and restoring balance across tissues.

Cannabinoids and other botanical actives join that process by working with enzymes that make and break down our endocannabinoids. Many consumers do not realize that molecules like CBGa or CBDa help stabilize signals by influencing TRP channels, serotonin pathways, and even inflammatory gene expression. When the Master Regulator gets the support it needs, those overactive immune messages start to taper down, tissues ease up, and the cycle of cellular strain gets a chance to break.

One study that helped push this understanding forward was the 2008 study "Anti-inflammatory properties of cannabidiol," which showed that cannabinoids can reduce inflammatory markers in damaged cells. I remember reading that paper and thinking how well it lined up with what I had already seen in patients using whole plant profiles or microdosed minors. The body wants homeostasis more than anything, and once you give the Master Regulator the right signals, you get stability instead of chaos.

When cellular breakdown is not tamed, inflammation becomes a daily burden. When it is managed through cannabinoid support and attention to ECS Balance, the patient feels like the weight has finally lifted.

If you need personal guidance on how to support your own balance, reach out

-Mike Robinson, The Researcher OG