31/01/2026
I often think about how stressful travelling for horses must be. This is interesting new research on the impact of travel on cortisol levels https://www.facebook.com/share/1CV6i7Jvyt/?mibextid=wwXIfr
Transdermal melatonin may be able to reduce physiological stress biomarkers in horses, specifically those induced by the stressors of transportation
Transportation acts as a serious physiological stressor for horses, triggering acute metabolic and hormonal changes that can compromise their welfare.
In a recent study, a team of researchers discovered that the application of transdermal melatonin successfully lowered cortisol levels, suggesting it is a viable, non-invasive tool to mitigate equine transport stress.
The primary impact of transport on horse welfare is the activation of the hypothalamic-pituitary-adrenal (HPA) axis, which lead to a elevation in serum cortisol levels.
This hormonal surge is accompanied by metabolic disturbances, including increased glucose levels due to cortisol-driven gluconeogenesis and heightened markers of muscular strain like creatinine and bilirubin.
These changes reflect the physical toll of prolonged confinement and the effort required for horses to balance themselves during the ride.
Transportation also leads to dehydration and electrolyte imbalances, specifically causing lower potassium and higher sodium levels.
The study notes that the resulting sodium-to-potassium ratio in transported horses approaches levels seen in pharmacological diuresis, which raises significant concerns for post-transport health issues such as colic or metabolic disorders.
The team explored transdermal melatonin as a potential welfare management tool, finding that it effectively reduces cortisol concentrations in horses.
While melatonin does not eliminate all transport-induced effects, its ability to attenuate HPA activity suggests it may help protect horses against the cumulative oxidative and hormonal stress associated with transit.
Full paper - Effect of transdermal melatonin on circulating cortisol and blood chemistry in horses exposed to transport stress. W.L. Crossland, E.O. Aviles-Rosa, E.B. Perry, C. Crowell, E. Webberson, J. Brown, J. Fassbender.