13/03/2026
Allostatic load: one of the most important causes of pain you’ve never heard of.
Many people think pain only comes from injury or physical strain. But research increasingly shows that long-term stress on the body and mind can also play a major role in pain. This concept is called allostatic load. 🧠
https://doi.org/10.1097/j.pain.0000000000003716
Allostasis is the body’s way of maintaining balance when life throws challenges at us. But when stress is frequent, prolonged, or overwhelming, the body’s systems can become overloaded. The cumulative wear and tear this creates is known as allostatic load.
Why this matters for pain
When the body is under constant stress, it can affect multiple systems including the brain, hormones, immune system and metabolism. Over time, this may reduce resilience and make the nervous system more sensitive to pain signals.
Research suggests that allostatic load can contribute to:
• Persistent musculoskeletal pain
• Migraines
• Fibromyalgia
• Arthritis
• Increased pain sensitivity and slower recovery
Chronic stress may even influence areas of the brain involved in pain processing, emotion and memory, including the hippocampus, amygdala and prefrontal cortex. Changes in these systems can increase the likelihood that pain becomes persistent.
What can help reduce allostatic load?
The encouraging news is that supporting overall health can help the body become more resilient. Research highlights the importance of:
✔ Good sleep habits
✔ Regular movement and exercise
✔ Healthy nutrition
✔ Managing stress and emotional wellbeing
✔ Addressing pain early and holistically
At City Osteopaths, we consider the whole picture of health, not just the painful area. Osteopathic care can help support the body’s natural ability to adapt, recover and move more comfortably.
If you’re experiencing persistent pain, we’re here to help.
Book an appointment here:
https://clientportal.uk.zandahealth.com/clientportal/cityosteopaths
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