30/10/2025
🚨 A potential game-changer for Alzheimer’s treatment
Scientists may have found a simple, affordable way to reverse Alzheimer’s symptoms — using a low-dose lithium supplement.
A groundbreaking study published in Nature has revealed that restoring the brain’s natural lithium levels could not only shield against Alzheimer’s disease but also reverse memory loss — at least in mice. Researchers discovered that reduced brain lithium levels were consistently linked to the disease’s key hallmarks, including amyloid plaques, tau tangles, and cognitive decline.
In experiments, mice with depleted lithium levels showed accelerated brain damage, creating a vicious cycle: low lithium worsened plaques, and plaques further reduced lithium. When treated with lithium orotate — a form better able to reach the brain than standard lithium carbonate — the animals regained memory function and showed reversal of brain damage. This promising effect was not seen with conventional lithium treatments, which may explain why past human trials had mixed results.
If replicated in people, this approach could offer a safe, multi-targeted therapy for dementia — without the high costs of current anti-amyloid drugs. Since lithium is inexpensive and unpatentable, large-scale human trials will likely require public funding rather than pharmaceutical backing. Researchers are cautiously optimistic, noting that higher natural brain lithium levels were also associated with stronger memory in healthy individuals. With Alzheimer’s affecting over 55 million people worldwide, this discovery could mark a turning point in the fight against one of aging’s most devastating diseases.
📚 Source: Peeples, L. (2025). New hope for Alzheimer’s: lithium supplement reverses memory loss in mice. Nature.
