Ναταλία Δημητρακοπούλου Παθολογικό & Διαβητολογικό Ιατρείο

13/03/2025

Common Pathway of Diabetic Foot Ulcer Occurence and Recurrence http://www.nejm.org/doi/full/10.1056/NEJMra1615439?utm_source=Facebook&utm_medium=social&utm_campaign=David+G.+Armstrong&utm_content=Facts1 #.WUQe84njVig.twitter

12/03/2025

https://www.nature.com/articles/s42255-025-01226-9
Brain insulin responsiveness is linked to long-term weight gain and unhealthy body fat distribution.

In this study, researchers investigated the effect of a 5-day high-caloric diet (HCD) that included broadly available and commonly consumed, calorie-rich ultra-processed snacks in addition to the regular diet, compared with a regular diet,
- on brain insulin action,
- body fat composition
- and peripheral insulin sensitivity.

It was shown that short-term overeating with calorie-rich sweet and fatty foods triggers liver fat accumulation and disrupted brain insulin action that outlasted the time-frame of its consumption in healthy weight men.

Hence, brain response to insulin can adapt to short-term changes in diet before weight gain and may facilitate the development of obesity and associated diseases.

Short-term overeating with calorie-rich snacks is shown to disrupt insulin action in the brain of men, which outlasted the time-frame of overeating.