13/10/2025
๐งช Glutathione: The Master Antioxidant
Among the vital molecules sustaining human life, Glutathione (GSH) stands as the cornerstone of cellular defense and rejuvenation. Often called the โMaster Antioxidant,โ it governs detoxification, redox balance, mitochondrial protection, and even influences skin health.
โ๏ธ The Biochemistry of Glutathione
Glutathione is a tripeptide composed of glutamate, cysteine, and glycine, linked by a rare ฮณ-peptide bond that grants stability. Its power lies in the sulfhydryl (-SH) group of cysteine, capable of donating electrons to neutralize free radicals and peroxides.
2 GSH โ GSSG + 2Hโบ + 2eโป
This reversible reaction, maintained by glutathione reductase (GR) using NADPH, defines cellular redox homeostasis. The GSH/GSSG ratio reflects mitochondrial health and oxidative resilience.
๐ฌ Cellular and Clinical Roles
โข Antioxidant Defense: Protects membranes, proteins, and DNA from oxidative injury.
โข Detoxification: Conjugates toxins and heavy metals through glutathione S-transferases (GSTs) for safe elimination.
โข Mitochondrial Protection: Maintains energy metabolism and prevents oxidative collapse.
โข Immune Regulation: Supports T-cell activity and cytokine modulation.
โข Neuroprotection: Preserves neuronal integrity in neurodegenerative disorders.
Low glutathione levels are associated with diabetes, liver steatosis, neurodegeneration, autoimmune diseases, and chronic fatigue conditions.
๐ฟ The Ayurvedic Parallels
In Ayurveda, glutathione embodies the harmony of Agni (metabolic fire), Ama (toxic residue), and Ojas (vital essence).
โข Agni Deepaka: Enhances intracellular metabolism and enzymatic transformation.
โข Ama Pachaka: Neutralizes oxidative waste, preventing cellular toxicity.
โข Ojas: Preserves tissue strength, clarity, and immunity the essence of health.
๐ Glutathione in Cosmetic and Skin Health
In dermatology, glutathione plays a dual role antioxidant protection and skin tone modulation. It inhibits tyrosinase, the key enzyme in melanin synthesis, shifting pigmentation toward lighter pheomelanin. This results in brighter, more even skin tone and protection against UV-induced damage.
By reducing oxidative stress and inflammation, glutathione helps maintain collagen integrity, elasticity, and overall dermal health. Oral, topical, and IV forms are used clinically, often combined with vitamin C and alpha-lipoic acid.
โ๏ธ Enhancing Glutathione Naturally
โข Precursors: N-acetylcysteine (NAC), selenium, vitamin C, and alpha-lipoic acid.
โข Dietary Sources: Garlic, broccoli, kale, turmeric, and amla.
โข Ayurvedic Herbs: Haridra (Turmeric), Amalaki, Tulasi, and Ashwagandha enhance antioxidant balance.
๐งญGlutathione is more than an antioxidant; it is the biochemical foundation of balance, vitality, and longevity.
In molecular terms, it sustains redox homeostasis and cellular detoxification.
By:- Dr Immanuel Job Wilson
Chief Physician
Zeon Ayurveda
