20/02/2026
A 2023 systematic review and meta-analysis published in Reproductive Biology and Endocrinology evaluated the role of inositol in women with PCOS.
After analysing 26 randomized controlled trials involving 1,691 women, researchers found that those taking inositol were nearly 1.8 times more likely to regain regular menstrual cycles compared to women receiving placebo. Cycle regularity is one of the most important clinical goals in PCOS management.
The review also reported meaningful improvements in metabolic and hormonal health. Women on inositol showed:
• Lower fasting glucose and insulin levels
• Reduction in total and free testosterone and androstenedione
• Increase in SHBG (s*x hormone-binding globulin)
• A small but favorable reduction in BMI
When compared with metformin, inositol showed similar effectiveness across most outcomes, while maintaining a strong safety and tolerability profile.
In short, evidence suggests that inositol is not just a cycle regulator — it may support the broader metabolic and hormonal imbalances seen in PCOS.
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