07/02/2021
*SHARING KNOWLEDGE IS GREAT TRIBUTE TO*
*Dr Prafull Vijayakar Sir's...*
🍁🍁🍁🍁🍁
*PARKINSON'S DISEASE*
" A disorder of the central nervous system that affects movement with tremors."
⬇️
Nerve cell damage in brain causes dopamine level to drop and leading to Parkinson's disease.
*HOW IT DEVELOPS..?*
Substantia nigra(SN) is the largest nucleus in the midbrain.
⬇️
SN appears darker than neighbouring areas.
⬇️
Due to high level of Neuromelanin in dopaminergic neurons.
⬇️
Pars Compacts - cells of pars compacta has dark pigment of Neuromelanin which is synthesizing dopamine.
⬇️
*Death of dopaminergic neurons* is called *Parkinson's disease.*
⬇️
Death of dopaminergic neurons is due to cellular disturbances produced by protein misfolding and aggregation, disruption of autophagic catabolism, endoplasmic reticulum (ER) stress, mitochondrial dysfunction, or loss of calcium homeostasis.
[Levodopa crosses BLOOD BRAIN BARRIER -and increases dopamine levels in SN].
*LAYER*
Layer 6 & 7
*MIASM*
Syco - Syphilis
*APPROACH*
GCS
*WHAT SHOULD IMPROVE FIRST?..*
If balance getting tilted, morphology affected, attack on the structure..... Then, this to be corrected first.
First stature should improve as anatomy should be corrected then physiology.
Distortion of posture occurs last in advanced case of Parkinson's disease and it should be first to improve.
{After child is born, alignment is first formed, then physiological functions follow.}
*POSSIBLE RUBRICS DISCUSSED BY SIR*
🔖 Delusion, he will be arrested.
🔖 Delusion, police man coming.
🔖 Respiration arrested.
🔖 Expiration arrested.
Compiled by dr LalithaThiru
🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻