17/12/2025
🔰IBD-ENC Journal Recommendation - Multi-Omics Analysis of Ileal Mucosa and Mesentery Before and After Ileocecal Resection in Crohn's Disease.
👉Crohn’s disease (CD) is a chronic inflammatory condition affecting any part of the gastrointestinal tract, with the ileocecal region often being the initial site of involvement. This study explored the microbial and metabolic impacts of ileocecal resection in early CD to better understand its therapeutic value. Using 16S rRNA sequencing and LC-MS/MS, researchers analyzed 68 samples of terminal ileal mucosa and mesentery from 34 CD patients before and after surgery. Results demonstrated improved microbial diversity and metabolic health in both tissues post-resection, alongside distinct spatial changes in microbial and metabolite profiles. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis further revealed key metabolic shifts associated with remission. These findings highlight ileocecal resection as an effective intervention that not only reduces inflammation but also restores microbial homeostasis, providing multi-omics evidence for its role in guiding precision, microbiome-informed treatment strategies for Crohn’s disease.
This IBD-ENC journal review discusses a high-impact research article published in the United European Gastroenterology (UEG) Journal, available on the wiley ...