Thesaferx

26/09/2022

With an 83% reduction in the risk of disease recurrence in early-stage lung cancer, Astrazeneca’s Tagrisso takes the top spot.

17/08/2022

When cancer had spread to the brain!

41 people who had tumors spread to the brain before the study were evaluated. 22 of them were treated with TAGRISSO and 19 were treated with gefitinib or erlotinib to see how it affected their brain tumors.

The study found:
77% of those taking TAGRISSO saw their brain tumors shrink. 18% saw their brain tumors completely disappear
63% of those treated with other EGFR-targeted therapies, erlotinib or gefitinib, saw their brain tumors shrink. No one saw their tumors completely disappear.

11/01/2022

Recent developments in mushrooms as anti-cancer therapeutics

From time immemorial, mushrooms have been valued by humankind as a culinary wonder and folk medicine in Oriental practice. The last decade has witnessed the overwhelming interest of western research fraternity in pharmaceutical potential of mushrooms. The chief medicinal uses of mushrooms discovered so far are as anti-oxidant, anti-diabetic, hypocholesterolemic, anti-tumor, anti-cancer, immunomodulatory, anti-allergic, nephroprotective, and anti-microbial agents. The mushrooms credited with success against cancer belong to the genus Phellinus, Pleurotus, Agaricus, Ganoderma, Clitocybe, Antrodia, Trametes, Cordyceps, Xerocomus, Calvatia, Schizophyllum, Flammulina, Suillus, Inonotus, Inocybe, Funlia, Lactarius, Albatrellus, Russula, and Fomes. The anti-cancer compounds play crucial role as reactive oxygen species inducer, mitotic kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoisomerase inhibitor, leading to apoptosis, and eventually checking cancer proliferation. The present review updates the recent findings on the pharmacologically active compounds, their anti-tumor potential, and underlying mechanism of biological action in order to raise awareness for further investigations to develop cancer therapeutics from mushrooms. The mounting evidences from various research groups across the globe, regarding anti-tumor application of mushroom extracts unarguably make it a fast-track research area worth mass attention.

11/01/2022

Blood Test Better Predicts Who Can Benefit From Lung Cancer Screening

A personalized lung cancer risk assessment that includes a blood test, developed by researchers at the University of Texas MD Anderson Cancer Center, identified 9.2 percent more lung cancer cases for screening and reduced referral to screening among non-cases by 13.7 percent, a study published Jan. 7 in the Journal of Clinical Oncology found.

A blood test would identify people who could benefit from lung cancer screening but are not eligible today. Tens of millions of people worldwide could benefit from lung cancer screening. If you can improve screening eligibility by even 5 percent, that is incredibly impactful.

11/01/2022

The FDA granted breakthrough therapy designation to telisotuzumab vedotin for treatment of certain patients with non-small cell lung cancer.

Overall response rate per central review among patients with at least 12 weeks of follow-up serves as the primary endpoint. Previously reported interim analysis results showed ORRs of 53.8% among patients with EGFR wild-type nonsquamous NSCLC with high c-Met expression and 25% among those with intermediate c-Met expression.

28/08/2021

take action here.

Cancer is a group of diseases characterized by uncontrolled growth and spread of abnormal cells. There are over 100 types of cancer, and any part of the body can be affected.[1]

The most common cancers diagnosed in men are prostate, lung, and colorectal cancers. For women, the 3 most common cancers are breast, lung, and colorectal.[2]

In 2020, there will be an estimated 1.8 million new cancer cases diagnosed and 606,520 cancer deaths in the United States.[3]

80% of all cancers in the United States are diagnosed in people 55 years of age or older.[4]

Childhood cancers account for 1 percent of all new cancer diagnoses. In 2018, about 15,590 children and teens ages (ages 0-19) were diagnosed with cancer. Although uncommon, cancer is the leading cause of death by disease in children.[5]

About 67% of Americans diagnosed with cancer survive five or more years after their diagnoses.[6]

In 2016, there were an estimated 15.5 million cancer survivors in the US. The number of cancer survivors is expected to increase to 20.3 million by 2026.[7]

Cancer is the second leading cause of death globally -- it accounts for 1 in 6 deaths around the world.[8]

Globally, approximately 70% of deaths from cancer occur in low- and middle-income countries.[9]

30-50% of cancer cases are preventable. The following behaviors can help reduce the risk of cancer: maintaining a healthy body mass index, eating high amounts of fruits and vegetables, exercising regularly, avoiding to***co use, and limiting alcohol use.[10]

To***co use is the largest preventable cause of cancer. Smoking to***co accounts for 30% of all cancer deaths and 80% of all lung cancer deaths. Encourage your loved ones to quit smoking.

28/08/2021

12/08/2021

Is cancer genetic?

Genetic factors can contribute to the development of cancer.

A person’s genetic code tells their cells when to divide and expire. Changes in the genes can lead to faulty instructions, and cancer can result.

Genes also influence the cells’ production of proteins, and proteins carry many of the instructions for cellular growth and division.

Some genes change proteins that would usually repair damaged cells. This can lead to cancer. If a parent has these genes, they may pass on the altered instructions to their offspring.

Some genetic changes occur after birth, and factors such as smoking and sun exposure can increase the risk.

Other changes that can result in cancer take place in the chemical signals that determine how the body deploys, or “expresses” specific genes.

Finally, a person can inherit a predisposition for a type of cancer. A doctor may refer to this as having a hereditary cancer syndrome. Inherited genetic mutations significantly contribute to the development of 5–10 percent of cancer cases.

12/08/2021

Cancer facts

Cancer comes from overproduction and malfunction of the body's own cells.

Cancer is the uncontrolled growth of abnormal cells anywhere in a body.

There are over 200 types of cancer.

Anything that may cause a normal body cell to develop abnormally potentially can cause cancer; general categories of cancer-related or causative agents are as follows: chemical or toxic compound exposures, ionizing radiation, some pathogens, and human genetics.

Cancer symptoms and signs depend on the specific type and grade of cancer; although general signs and symptoms are not very specific the following can be found in patients with different cancers: fatigue, weight loss, pain, skin changes, change in bowel or bladder function, unusual bleeding, persistent cough or voice change, fever, lumps, or tissue masses.

Although there are many tests to screen and presumptively diagnose cancer, the definite diagnosis is made by examination of a biopsy sample of suspected cancer tissue.

Cancer staging is often determined by biopsy results and helps determine the cancer type and the extent of cancer spread; staging also helps caregivers determine treatment protocols. In general, in most staging methods, the higher the number assigned (usually between 0 to 4), the more aggressive the cancer type or the more widespread is cancer in the body. Staging methods differ from cancer to cancer and need to be individually discussed with your health care provider.

Treatment protocols vary according to the type and stage of cancer. Most treatment protocols are designed to fit the individual patient's disease. However, most treatments include at least one of the following and may include all: surgery, chemotherapy, and radiation therapy.

There are many listed home remedies and alternative treatments for cancers but patients are strongly recommended to discuss these before use with their cancer doctors.

The prognosis of cancer can range from excellent to poor. The prognosis depends on the cancer type and its staging with those cancers known to be aggressive and those staged with higher numbers (3 to 4) often have a prognosis that ranges more toward poor.