06/09/2025
I was today years old when I learned this mind blowing Neuro anatomical fact.
The terminal nerve, also known as cranial nerve zero (CN 0), is possibly the thirteenth cranial nerve.
🎬This small, mysterious cranial nerve is considered the "0" nerve because it lies anterior (in front) of the olfactory nerve (CN I).
🧠CN ‘0’ is a bilateral plexus of unmyelinated nerve fibers. It originates in the nasal mucosa and travels through the cribriform plate of the ethmoid bone, a structure also used by the olfactory nerve. From there, it courses along the ventral surface of the brain, medial to the olfactory tract and bulb, before entering the forebrain.
Its presence is more prominent in human fetuses, though it has been identified in adults. Unlike the other cranial nerves, which are typically defined by their clear structure and function, the terminal nerve is more of a network (plexus) of fibers with scattered ganglia (clusters of nerve cells).
Function and Controversy 🔬
The exact function of CN ‘O’ in humans is controversial.
It is believed to play a role in reproductive behavior and the unconscious perception of pheromones.
This is supported by its connections to the hypothalamus, a brain region that regulates hormonal systems, and its association with gonadotropin-releasing hormone (GnRH).
Unlike the olfactory nerve (CN I), which is responsible for the conscious perception of smell, the terminal nerve is not thought to be involved in traditional olfaction.
Instead, it's speculated to detect non-odorant chemical signals that influence behavior.
Despite being identified over a century ago, the terminal nerve is ignored in most anatomy textbooks.