24/10/2025
Can you say which stage of AML causes this typical Gingival Hypertrophy?
🦷 Etiology of Gingival Hypertrophy
1. Inflammatory causes
Chronic gingivitis due to poor oral hygiene → plaque accumulation
Periodontitis
Secondary infection (bacterial, fungal, viral)
2. Drug-induced
Anticonvulsants → Phenytoin (most classic)
Calcium channel blockers → Nifedipine, Amlodipine, Verapamil
Immunosuppressants → Cyclosporine
(Less commonly: Valproate, Phenobarbital)
3. Hormonal
Puberty → increased s*x hormones enhance gingival response to plaque
Pregnancy → “pregnancy gingivitis”
Oral contraceptive use
4. Nutritional deficiency
Vitamin C deficiency (Scurvy) → swollen, bleeding gums
5. Systemic diseases
Leukemia (esp. AML, ALL) → infiltration of leukemic cells into gingiva
Granulomatous diseases (sarcoidosis, Wegener’s, Crohn’s)
6. Idiopathic or Hereditary
Hereditary gingival fibromatosis → dense, fibrous, noninflammatory overgrowth
7. Local irritants
Dental plaque, ill-fitting restorations, orthodontic appliances, or mouth breathing