ICPRM

ICPRM Dr. Raut's Centre for Reproductive Immunology is the first centre established in India, to give spec

ICPRM is the first centre established in India, to give specialised treatment to patients suffering from repeated pregnancy loss . It provides complete Diagnostic set up and comprehensive treatment, including Immunotherapy, for women with Repeated Miscarriages. ICPRM has a fully equipped facility for Specialised & Advanced Care. Located in Mumbai, India, it provides services to patients across India and also from overseas. We invite you to learn more about ICPRM clinical offerings, treatments, research, and community initiatives by exploring this website. Couples who come to this centre often have had the painful experience of recurrent pregnancy loss or repeated unexplained IVF failures. Many of these couples have already attempted pregnancy with the aid of assisted reproductive technology (ART) without success. However, ICPRM is not here to offer the latest fad treatment. The diagnostic procedures and therapies practiced at the Centre have evolved over many years while they are continually being assessed and developed.

07/03/2026

Motherhood is a dream for many women.

And today, with advances in reproductive immunology, science is helping turn that dream into reality, even for those who have faced repeated heartbreak.

Tomorrow, 8th March at 3.20pm, on Pudhari News, I will be discussing how ImmuLIT® treatment is bringing hope to couples facing repeated miscarriages, IVF failures, and unexplained infertility.

Every woman deserves the chance to experience motherhood if she wishes.

With the right diagnosis, the right science, and the right support, hope can truly become life.

On 8th March on Pudhari News at 3.20 pm!

Helpline number: +919833201522
www.icprm.in


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THE REASON BEHIND OUR SMILES…“Doctor, we have done everything… IUI and even IVF. We don’t know why we are still not conc...
04/03/2026

THE REASON BEHIND OUR SMILES…

“Doctor, we have done everything… IUI and even IVF. We don’t know why we are still not conceiving.”

When she said this, it wasn’t just a question. It was eight years of silent struggle speaking at once.

She was 33 years old, married for eight years, and like many couples with unexplained infertility, they had tried everything that modern fertility treatment could offer.

They had undergone IUI, then moved on to IVF, hoping each time that this cycle would finally bring the long-awaited good news.

But every attempt ended the same way.

No pregnancy.

Their reports looked reassuring. Hormones were normal. There was no obvious problem. And yet, the dream of parenthood remained out of reach.

When they came to Dr. Raut’s Centre for Reproductive Immunology, the focus shifted to a dimension often overlooked in routine fertility workups—the immune system’s role in pregnancy.

Further evaluation suggested an allo-immune imbalance, where the maternal immune system may fail to develop the tolerance needed for implantation and continuation of pregnancy.

The couple underwent ImmuLIT®, the patented immunomodulatory therapy offered at our centre.

Soon after, the long-awaited moment finally arrived.

She conceived.

The pregnancy progressed carefully, and although the baby arrived a little earlier than expected, the most beautiful sound filled the room—the cry of their baby boy.

And THAT PRECIOUS LITTLE LIFE BECAME THE REASON BEHIND OUR SMILES....!

04/03/2026

Repeated biochemical pregnancies are often interpreted as reassuring because fertilization and early implantation have occurred.

But when this happens repeatedly, it raises an important clinical question:

Why does implantation begin, but the pregnancy fail to sustain itself?

Pregnancy is not only a reproductive event — it is also an immunological interaction between the mother and the embryo.

The embryo carries material from both parents, and the maternal immune system must develop tolerance toward this semi-allogenic entity.

In certain cases, implantation may initiate, yet the immune environment may not adequately support the continuation of pregnancy.

This may present clinically as:
• Repeated biochemical pregnancies
• Early miscarriages
• IVF implantation failures despite good embryos

When routine fertility investigations appear normal, exploring the immune dimension of implantation and early pregnancy may provide additional insights.

Understanding the why behind repeated early pregnancy losses can help guide more targeted approaches to improving outcomes.

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+919833201522
www.icprm.in

Happy Holi!                ®
03/03/2026

Happy Holi!

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02/03/2026

हर IVF फेल्योर सिर्फ “बैड लक” नहीं होता।
हर मिसकैरेज सिर्फ “कमज़ोर एम्ब्रियो” की वजह से नहीं होता।

कभी-कभी समस्या हार्मोन में नहीं…
समस्या इम्यून टॉलरेंस में होती है।

जब माँ का इम्यून सिस्टम
पिता के जेनेटिक मटेरियल को पूरी तरह स्वीकार नहीं करता,
तो इम्प्लांटेशन प्रभावित हो सकता है।

ImmuLIT® जादू नहीं है।
यह इम्यून सिस्टम को प्रशिक्षित करने की वैज्ञानिक प्रक्रिया है।

- चयनित मरीजों में
- सही जांच और इम्यून मूल्यांकन के बाद
- नियंत्रित और प्रोटोकॉल आधारित उपयोग के साथ इम्यून संतुलन सुधर सकता है —
और परिणाम बदल सकते हैं।

📍 Dr. Raut’s Centre for Reproductive Immunology
+91 9820894047 | www.icprm.in

ADVANCING IVF OUTCOMES THROUGH IMMUNOLOGY USING ImmuLIT® | ISAR ANNUAL CONFERENCE, AHMEDABAD I am pleased to share that ...
21/02/2026

ADVANCING IVF OUTCOMES THROUGH IMMUNOLOGY USING ImmuLIT® | ISAR ANNUAL CONFERENCE, AHMEDABAD

I am pleased to share that I delivered a talk at the Annual ISAR Conference held in Ahmedabad on the topic:

“Lymphocyte Immunization Therapy (ImmuLIT®) in IVF.”

Despite advances in assisted reproductive technologies, many IVF cycles continue to fail—even when embryo quality and uterine factors appear optimal.

Increasingly, research and clinical experience point toward the role of the maternal immune system in determining implantation success and pregnancy continuation.

In my session, I highlighted:
✔ The role of allo-immune imbalance in repeated IVF failures
✔ Why routine fertility investigations may miss immune-mediated implantation issues
✔ The science behind active immunomodulation through ImmuLIT®
✔ Clinical insights on improving implantation and live birth outcomes in select patients

As reproductive medicine evolves, integrating structured immunological evaluation into IVF workup may offer new hope for couples facing unexplained failures.

Because sometimes, when everything looks right....

this is exactly where reproductive immunology quietly changes outcomes.

Dr. Raut’s Centre for Reproductive Immunology

M: +91 9820183757
www.icprm.in

Today morning began with a lovely surprise!A close friend sent us a message saying,"Look, your work has been featured in...
21/02/2026

Today morning began with a lovely surprise!

A close friend sent us a message saying,
"Look, your work has been featured in Gujarati Midday today!"

And there it was, an article talking about the role of the immune system in fertility, and how Reproductive Immunology is quietly changing outcomes in couples struggling with repeated IVF failures, recurrent miscarriages, and unexplained infertility.

For years, Dr. Mohan Raut and I at Dr. Raut’s Centre for Reproductive Immunology have been working alongside IVF specialists and gynecologists across India to address one often-missed piece of the fertility puzzle........... the maternal immune system.

Because sometimes…
✔ The embryos are good
✔ The uterus looks normal
✔ The hormones are balanced
✔ The reports say “everything is fine”
…and yet pregnancy doesn’t continue.

This is exactly where reproductive immunology quietly changes outcomes.

We are grateful that conversations around immune-mediated reproductive challenges are now reaching beyond conference halls and medical journals," into mainstream media", and hopefully into the awareness of couples who have been told that their infertility is “unexplained.”

Thank you to Gujarati Midday for helping bring this important conversation into the public domain.

Dr. Raut’s Centre for Reproductive Immunology
www.icprm.in
+91 98332 01522

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Honoured to be a part of the panel discussion on "Pre-IVF Workup" at the Annual Conference of the Indian Society for Ass...
20/02/2026

Honoured to be a part of the panel discussion on "Pre-IVF Workup" at the Annual Conference of the Indian Society for Assisted Reproduction (ISAR), Ahmedabad 2026.

Pre-IVF evaluation has "traditionally" focused on optimizing three key areas:
1. embryo quality,
2. uterine anatomy, s***m quality and
3. hormonal environment.

While these remain essential, our discussion today also explored an important and often under-addressed dimension in selected patients--- the role of the immune system in implantation and early placentation.

Implantation is not merely a procedural step following embryo transfer.

It is a highly regulated immunological event that requires the maternal immune system to shift from a state of defense to one of tolerance.

In patients with:
• Recurrent implantation failure
• Recurrent pregnancy loss
• Unexplained infertility
• Repeated biochemical pregnancies
• Previous IVF failures despite good-quality embryos
…the question may not always be “Can the embryo implant?”

but rather, “Will the immune system allow it to implant?”

"This is exactly where reproductive immunology quietly changes outcomes."

Grateful for the opportunity to contribute to this meaningful conversation with colleagues working at the forefront of fertility care, and for the growing recognition that selective immune evaluation may be an important part of pre-IVF workup in appropriate clinical scenarios.

Looking forward to continued dialogue on integrating evidence-based immunological perspectives into routine fertility practice.

+919833201522
www.icprm.in

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18/02/2026

Another IVF cycle?

If your reports are normal…
your embryos are good…
and IVF still failed —
don’t just repeat treatment.
Ask one important question:
Why did it fail?

Pregnancy is not just about making an embryo.

It’s also about your immune system accepting it.

Before the next IVF,
make sure you’re not missing the immune conversation.

+91 98332 01522
www.icprm.in





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TEN PREGNANCIES LOST - ONE IMMUNE ANSWER FOUND!For eight years of marriage, their life moved in a painful rhythm -hope, ...
17/02/2026

TEN PREGNANCIES LOST - ONE IMMUNE ANSWER FOUND!

For eight years of marriage, their life moved in a painful rhythm -hope, heartbreak, hope, heartbreak, hope, heartbreak.....10 times.

She was 36. Till then they conceived ten times.

-Seven natural pregnancies.
-Two through IUI.
-One through IVF.

Not one baby came home.

Every positive test brought joy they were almost afraid to feel.

Then,every loss left them quieter, more guarded, more broken.

Celebrations turned into silence.

Baby clothes were never bought.

Due dates became days to survive.

After this, they endured two failed IUIs and two failed IVF cycles, all while being told their reports were “fine” and embryos were “good.”

Yet pregnancy slipped away again and again, leaving them with grief no test report could explain.

By the time they reached Dr. Raut's Centre for Reproductive Immunology, they were emotionally exhausted.

But here, the search went deeper & different, beyond hormones and scans, into the immune system’s role in pregnancy.

Testing revealed an allo-immune factor, an unseen reason her body struggled to sustain life.

They underwent ImmuLIT® therapy.

They didn’t dare to hope loudly anymore.
And then, quietly, life surprised them.

She conceived naturally.

The early weeks were filled with fear disguised as calm. Every appointment felt like standing at the edge of a cliff.

But this time, there was no fall. No sudden loss. No devastating call.

Just a growing heartbeat.
A steady pregnancy.
A miracle unfolding week by week.

Months later, after ten goodbyes, they finally heard the cry they had dreamed of for years, their healthy baby boy.

For them, he is not just a child.

He is healing.
He is proof that answers exist.
He is the moment their story changed forever.

And when they held him for the first time, these were the only words they could find:

“We are truly speechless and forever grateful for the care we received. Dr. Raut’s ImmuLIT® patented therapy has given us the biggest joy of our lives after years of struggle.”



16/02/2026

After 2, 3 or sometimes even 4 failed IVF cycles, many couples are advised to try another cycle.

And often, they do, with hope…
with emotional courage…
and with significant financial investment.

But before repeating treatment, it is important to ask a fundamental question:
Why did the previous IVF cycles fail?

In many such cases, routine fertility parameters are reassuring.
Hormones are normal.
The uterine structure appears receptive. The s***m quality is good.
Embryos are of good quality, sometimes even genetically tested.

And yet, implantation does not occur.

Or pregnancy begins… but does not continue.

While IVF helps in creating embryos,
a successful pregnancy also depends on the maternal immune system’s ability to accept that embryo.

In certain situations, an underlying immune imbalance may interfere with implantation or early pregnancy continuation, even when standard investigations appear normal.

A structured immunological evaluation, in selected cases, may provide additional insights before proceeding with another IVF cycle.

In this video, I discuss the importance of pausing to investigate, before repeating treatment.

If you’ve encountered repeated IVF failures, recurrent pregnancy losses, or unexplained infertility in your clinical practice, it may be worth considering whether reproductive immunology evaluation could play a role in optimizing outcomes.

www.icprm.in
+91 98332 01522


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Karlton Apartment, Near Vakola Masjid
Mumbai
400055

Telephone

+919833201522

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