07/12/2025
Pulmocure Nebpules (Formoterol + Budesonide) – Clinical Brief for OAD Management
Rationale in OAD:
The LABA–ICS combination remains a cornerstone in the management of Asthma, COPD, and ACO, especially in patients with persistent symptoms and airway inflammation.
Pharmacological Advantages:
Formoterol
Rapid onset (∼1–3 min) with long-acting bronchodilation (up to 12 hours).
Improves FEV₁, reduces dynamic hyperinflation, and enhances exercise tolerance.
Budesonide
Potent anti-inflammatory corticosteroid with high receptor affinity.
Reduces eosinophilic inflammation, mucosal edema, and airway hyperresponsiveness.
Fewer systemic side effects due to extensive first-pass metabolism.
Clinical Integration:
Proven efficacy in reducing exacerbation frequency and hospitalizations in OAD.
Beneficial for patients with poor inhaler technique, ensuring consistent drug delivery.
Nebulized route supports use in acute symptoms, elderly, pediatric, and co-morbid patients where coordination is compromised.
Therapeutic Outcomes:
Better symptom control and night-time relief
Improved pulmonary function
Enhanced adherence due to ease of use
Optimized deposition across variable inspiratory flows