Pathlogos

27/06/2021

https://youtu.be/zKHpqbxLp-I
With newer, deadlier strains and mutations of emerging, we need plus to fight it. Here’s one such breakthrough solution from an Indian scientist.
In collaboration with Shycocan Corporation









Shycocan

Introducing the world’s 1st proven technology to bring life back to normal – the Shycocan, a virus attenuation device that can disable the Coronavirus and In...

11/03/2021

"What goes around comes around"

28/02/2021

Amyloid 🍏

16/02/2021

Who am I?

14/02/2021

The image shows the list of immunohistochemistry(IHC)markers positive for hepatocellular carcinoma (HCC).
Hep Par1 is highly sensitive & specific for hepatocellular carcinoma &shows cytoplasmic stanining but both in normal & neoplastic hepatocytes thus cannot differentiate between hepatocellular adenoma vs hepatocellular carcinoma
But being highly sensitive & specific means it easily rules out other differentials likr renal cell carcinoma , adrenocortical carcinoma which appear similar in morphology.
Glypican 3 is highly sensitive and it can easily rule out benign vs malignant hepatic neoplasm,since they are only positive in hepatocellular carcinoma & not adenoma.
Polyclonal CEA has a specific canalicular pattern in HCC ,helps to differentiate from metastatic adenocarcinoma which have a cytoplamsic pattern rather.
Arginase too has high sensitivity & specificity for hepatic differentiation (origin) of tumor.
Afphafetoprotein has a patchy staining with sensitivity for 30-50% only.
Review Question:
IHC marker that differentiates benign vs maligant hepatic neoplasms is
A)Hep par1
B)Glypican3
C) AFP
D) All of the above
Answer) B Glypican 3Follow for more....

24/01/2021

MED12 mutation

17/01/2021

Gastrointestinal stromal tumor

16/01/2021

Spikes seen in membranous nephropathy are due to basement membrane material ( not immune complexes) that gets deposited in between the immune complexes.

09/01/2021

Barrett esophagus is identified grossly as one or several patches of red velvety mucosa extending upward.
This metaplasia alternates with grey pale white esophageal mucosa. This is evident on endoscopy and those salmon red colour areas are biopsied to confirm metaplasia histopathologically and also to rule out dysplasia.

Great Hair though 😍
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30/11/2020

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28/11/2020

anticipation is a phenomenon whereby as a genetic disorder is passed on to the next generation, the symptoms of the genetic disorder become apparent at an earlier age with each generation. In most cases, an increase in the severity of symptoms is also noted. Anticipation is common in trinucleotide repeat disorders, such as Huntington's disease and myotonic dystrophy, Fragile X syndrome.

28/11/2020

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