08/01/2026
GL Sciences Inertsil Hybrid-C18.
High-pH Tolerant HPLC Column for Robust and Reproducible Performance
Introduction & Key Features
Inertsil Hybrid-C18is a silica-basedreversed-phase column engineered with hybrid organic-inorganic
bonding technology, enabling exceptional chemical stability across a broad
pH range of 1–12.
● pH range 1–12 for both acidic and basic conditions
● Excellent batch-to-batch reproducibility
● Compatible with LC/MS, LC/MS/MS and high-pressure LC systems
● High durability and long lifetime, even under basic pH
● USP L1 classification (C18)
Specification
Base Material : High-pH Stable Hybrid Silica
Particle Size : 1.7 µm / 3.5 µm / 5 µm
Pore Size : 165 Å (16.5 nm)
Pore Volume : 1.00 mL/g
Surface Area : 185 m²/g
Carbon Load : 15%
End-capped : Yes
USP Code : L1
Max Temp : 80°C (pH 1 - 10), 60°C (pH 1 - 12)
pH Range : 1 – 12
Max Pressure 1.7 µm: 18,000 psi (124 MPa) — PEEK hardware: 14,500 psi (100 MPa) 3.5 µm: 7,200 psi (50 MPa) 5 µm: 6,000 p
A Legacy of Quality
Since the launch of Inertsil ODS-3 in 1994, we have consistently manufactured HPLC columns in-house—from the synthesis of base silica to final packing. This fully integrated production process is the foundation of our ability to deliver high-quality, highly reliable columns with unmatched consistency
Inertsil Hybrid-C18 was newly developed to meet the evolving needs of users, offering exceptional durability under high-pH mobile phase conditions. This column expands application flexibility while maintaining the trusted performance of the Inertsil series.
