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Dr Samir Contractor - Sterling Hospital

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Dr Samir Contractor - Sterling Hospital

Senior Consultant Laparoscopic, Bariatric and Anorectal Surgeon. Certified Exercise and Nutrition Coach

05/12/2025

The GLP-1 Revolution: What Patients Really Need to Know

GLP-1 medications like Ozempic, Wegovy, and Mounjaro are transforming how we treat diabetes and obesity. These drugs mimic a natural hormone that reduces hunger, slows stomach emptying, and improves insulin response—leading to better sugar control and 15–20% weight loss for many patients.

Beyond weight, research shows benefits for the heart and kidneys, making them valuable for patients with diabetes and metabolic risk.

But they’re not perfect. Early side effects like nausea, vomiting, and digestive issues are common but usually settle. Rare risks include pancreatitis and gallbladder problems. And yes—concerns about thyroid cancer remain theoretical, not proven in humans.

📌 Who may benefit:
• Type 2 diabetes with poor control
• Obesity (BMI >30) or obesity-related conditions
• High cardiovascular risk

⚠️ Who should be cautious:
History of pancreatitis, thyroid disease, pregnancy, or severe GI issues.

💰 Cost in India: ₹5,000–₹30,000/month depending on dose and brand.

🎯 Bottom Line

GLP-1 drugs are powerful tools—not magic solutions. They work best with the right lifestyle changes and proper medical supervision. For the right patient, they can be life-changing.

If you’re struggling with weight or diabetes, speak with a qualified specialist to understand whether GLP-1 therapy is right for you.

📞 Sterling Hospitals, Vadodara
👨⚕️ Dr Samir Contractor — Senior Consultant, Laparoscopic & Bariatric Surgery

27/11/2025

Biology vs. Behavior: What's Really Driving Weight Gain?

When it comes to weight gain, is your body working for you—or against you?

Obesity research increasingly points to a nuanced answer. While biology powerfully defends against weight loss, it’s surprisingly weak at preventing weight gain. The real driver? Behavior.

🔬 What the Science Says:

Biological compensation is asymmetrical:

--During calorie restriction, the body fights back—slowing metabolism, increasing hunger, and conserving energy. After 12–14 weeks of dieting, people often lose only ~60% of the expected weight.

--Resting energy expenditure drops before major weight loss even begins.

--Hunger ramps up post-weight loss, a key predictor of weight regain.

But when excess calories come in?

--Biological compensation is weak. In overfeeding studies (+1000 kcal/day), only ~15% of the extra energy is offset by metabolic increase.

💡 Behavioral Patterns Tell the Bigger Story:

--Women with lower physical activity saw 77% more weight gain over 12 months.

--Sleeping 4 vs. 9 hours led to ~300 kcal more consumption per day—mostly from fat.

--Vigorous exercise significantly reduced the risk of becoming overweight.

--Replacing sugar-sweetened drinks helped prevent excess weight in children.

Even modest energy gaps accumulate:

--U.S. adult weight gain since the 1970s? ~400 kcal/day on average.

🧬 While genetic factors matter, they explain just 1.45% of the variation in BMI across populations.

The takeaway? Our behaviors—movement, sleep, food choices—are the main forces shaping weight outcomes in an environment where biology struggles to keep up.

Let’s shift the focus from blame to empowerment: small, consistent behavior changes can outmaneuver our biology.

26/11/2025

Women, Heart Disease & Statins: Are We Targeting the Wrong Enemy?
For years, statins have been prescribed widely to lower LDL cholesterol. But when it comes to predicting heart disease in women, emerging evidence suggests we may be focusing on the wrong target.

1️⃣ Lipids vs. Metabolic Health — The Disconnect

Large cohort studies (including the Women’s Health Study) show a clear pattern:
Metabolic dysfunction — not LDL — is the dominant predictor of cardiovascular risk in women.

Here’s how the risk markers stack up:

LDL Cholesterol: 1.4× increased risk
The traditional target — but a weak predictor for women.

ApoB: 1.9× increased risk
Better than LDL, but its predictive value fades with age.

Metabolic Syndrome (Insulin Resistance): 6–6.5× increased risk
The upstream driver of most cardiovascular risk factors.

Type 2 Diabetes: 10.7× increased risk
The strongest predictor — far outranking lipid markers.

👉 Insulin resistance continues to predict heart disease even after adjusting for LDL.

2️⃣ The Statin Paradox

Statins are excellent at lowering LDL —
but LDL is a weak predictor of heart disease in women.

At the same time, statins can worsen insulin resistance — which is the strongest driver of cardiovascular events.

Key concerns in women:

Higher Diabetes Risk:
Statins increase the risk of new-onset Type 2 diabetes.
In post-menopausal women, this risk jumps by 48% — and diabetes increases cardiovascular risk more than 10×.

More Side Effects:
Women are twice as likely as men to experience muscle pain or weakness, affecting up to 25% of female users.
They also report more brain fog and depressive symptoms.

3️⃣ The Real Priority: Fix the Root Cause

Instead of reflexively chasing LDL reductions, we need to focus on what truly drives risk: insulin resistance and metabolic dysfunction.

Evidence-based strategies that improve metabolic health without unwanted side effects:

🏋️♀️ Resistance training
🍽️ Low-carb or smart-carb nutrition
😴 Sleep optimization
🧘♀️ Stress reduction

These lifestyle interventions target root physiology, not just surrogate markers.

Bottom line:
For women, especially in primary prevention, the strongest cardiovascular predictors are metabolic — not lipid.
It’s time to realign our focus from lowering numbers to improving metabolic health.

10/12/2024

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26/04/2024

Discover the different surgical treatment modalities of piles with our comprehensive guide:

1️⃣ Hemorrhoidectomy: This is the removal of excessive tissue that causes bleeding. It's the most effective method for severe or recurring piles.

2️⃣ Hemorrhoid stapling: This procedure is used to treat pr*****ed hemorrhoids. It involves stapling the blood vessels supporting the piles to reduce the blood supply, causing them to shrink.

3️⃣ Rubber band ligation: This involves placing a small rubber band around the base of the hemorrhoid to cut off its blood supply. The hemorrhoid will then shrink and fall off within a week.

4️⃣ Sclerotherapy: A chemical solution is injected into the blood vessel to shrink the hemorrhoid.

5️⃣ Laser Hemorrhoidoplasty: Laser energy is used to shrink the hemorrhoids. It's a relatively painless treatment modality.

6️⃣ Infrared coagulation: Infrared rays are used to coagulate the blood in the hemorrhoids, causing them to shrink.

Remember, early detection and treatment can prevent complications. Consult with your healthcare provider for the best treatment option.

Address

Sterling Hospital, Opposite Inox Cinema, Race Course Circke(West)
Vadodara
390007

Opening Hours

Monday	11am - 5pm
Tuesday	11am - 5pm
Wednesday	11am - 5pm
Thursday	11am - 5pm
Friday	11am - 5pm
Saturday	11am - 1pm

Telephone

+918238774581

Website

https://www.drsamircontractor.com/

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