16/04/2026
🩺 Hypertension: Combination Therapy Made Easy 💊
When BP isn’t controlled with one drug, it’s time to combine smartly—not randomly!
🔹 First-line combos (BEST choices):
✔ ACE inhibitor + Thiazide diuretic
✔ ARB + Thiazide
✔ ACE inhibitor + CCB
🔹 Alternative combos:
✔ CCB + ARB
✔ CCB + Thiazide
🚫 Avoid this dangerous combo:
❌ ACE inhibitor + ARB (↑ risk of hyperkalemia + renal failure)
⚡ Golden Exam Pearls:
• Always combine drugs with different mechanisms
• Start low → titrate slowly
• Check K⁺ & creatinine when using ACEi/ARB
• Resistant HTN? → Add spironolactone
🔥 Quick Trick:
👉 “A + D, A + C = SAFE; A + A = DANGER”
(A = ACE/ARB, D = Diuretic, C = CCB)
🩺 Hypertension: Combination Therapy Made Easy 💊
When BP isn’t controlled with one drug, it’s time to combine smartly—not randomly!
🔹 First-line combos (BEST choices):
✔ ACE inhibitor + Thiazide diuretic
✔ ARB + Thiazide
✔ ACE inhibitor + CCB
🔹 Alternative combos:
✔ CCB + ARB
✔ CCB + Thiazide
🚫 Avoid this dangerous combo:
❌ ACE inhibitor + ARB (↑ risk of hyperkalemia + renal failure)
⚡ Golden Exam Pearls:
• Always combine drugs with different mechanisms
• Start low → titrate slowly
• Check K⁺ & creatinine when using ACEi/ARB
• Resistant HTN? → Add spironolactone
🔥 Quick Trick:
👉 “A + D, A + C = SAFE; A + A = DANGER”
(A = ACE/ARB, D = Diuretic, C = CCB)
Hypertension NCLEXPrep Pharmacology NursingNotes MedEd