Human Technopole

20/02/2026

🧬 How do we push imaging beyond the diffraction limit to understand biology molecule by molecule?

🎙️ In this interview, Ralf Jungmann (MPI of Biochemistry), guest of our “HT Seminars: Connecting Discoveries” series, shares how DNA-PAINT is enabling new insights into molecular organisation and function.

🔬 The series brings leading international researchers to Human Technopole, strengthening interdisciplinary exchange across the life sciences.

👏 Thanks to our interviewers: Damian Edward Dalle Nogare (National Facility for Data Handling & Analysis) and Diya Srivastava (Jug Group, Computational Biology Research Centre), for guiding this conversation.

Watch the full interview 👉

How do we push imaging beyond the diffraction limit to understand biology molecule by molecule? In this interview, Ralf Jungmann (MPI of Biochemistry), guest...

19/02/2026

🧠 How do synapses regulate the proteins that enable learning and memory?

🔬 On 26 February 2026, we host Erin Schuman, Director at the Max Planck Institute for Brain Research, for the next “HT Seminars: Connecting Discoveries” talk. She will discuss how neurons produce and degrade proteins directly at synapses, and why this local control is essential for plasticity and brain function.

🌍 The HT Seminars series bring leading international scientists to MIND - Milan Innovation District to connect disciplines and spark exchange across genomics, structural biology, neurogenomics and health data science. By advancing basic research, we open new opportunities to understand complex biological systems and improve human health, together.

Register by 25 February 2026 👉 https://humantechnopole.it/en/training/external-training/external-seminar-series-2026/ #26-february-2026-erin-schuman

18/02/2026

🌱 Can a research campus change how we do science and how we live in a city?

🔬 In this interview, our Giovanni Maltinti, PhD student in the Gaia Pigino Group, reflects on two core values of Human Technopole and the wider MIND district: collaboration and innovation. Scientists working side by side, sharing tools and ideas, are essential to move research forward. Technologies such as cryo-electron microscopes, rare in Italy and across Europe, enable us to study life at unprecedented detail and open new paths towards discoveries that can improve life expectancy and quality of life.

Watch the interview 👉

Human Technopole at MIND Milano: empowering the next generation of scientists. Giovanni Maltinti, PhD student, shares how collaboration and innovation drive ...

14/02/2026

Our Piero Carninci, Head of Genomics Research Centre (Functional Genomics Programme), was a guest on Radio3 Scienza to explore a key question in biology: what does non-coding DNA really do?

🧬 With tools like AlphaGenome, AI can analyse up to one million DNA bases at once, helping predict the impact of mutations in regions once called “junk DNA”.

🤖 A step towards connecting data, biology and discovery to advance human health.

In Italian 👉

La lingua del DNA - Radio3 Scienza - Nel 2024 con AlphaFold si era aggiudicata il Premio Nobel per la chimica. Oggi l'azienda DeepMind di Google sulle pagine di Nature ha annunciato un nuovo strumento di ricerca: AlphaGenome. Il software, con l'aiuto dell'intelligenza artificiale, sarebbe in grado d...

13/02/2026

🧬 What if looking beyond known genes could unlock new cancer treatments?

💻 🔬 Our Lorenzo Calviello, Group Leader in the Genomics and Computational Biology Research Centres, has been awarded from Fondazione AIRC per la Ricerca sul Cancro to study how novel RNAs and proteins drive colorectal cancer and how they could become new targets for immunotherapy.

The project brings together computational biology, patient-derived organoids and advanced proteomics, powered by Human Technopole’s National Facilities and international collaboration.

Lorenzo Calviello and his group of the Human Technopole’s Research Centres for Genomics and Computational Biology have been awarded a five-year My First AIRC Grant by Fondazione AIRC per la Ricerca sul Cancro. The grant provides over €99,000 for 2026, for a total of €500,000, to support a proj...

05/02/2026

🔓A new Call for Access to our National Facilities is now open, building on a 147% year-on-year growth in proposals from the Italian research community.

🔬 From genomics to imaging and data analysis, researchers gain access to advanced technologies and dedicated scientific support.

🤝 An open, merit-based model designed to connect disciplines and accelerate discovery.

Discover more and submit your proposal 👉

Human Technopole has opened a new Call for Access to its National Facilities on 1 February 2026, offering researchers from Italy the opportunity to access cutting-edge technologies and expertise across the institute’s advanced research platforms.

03/02/2026

🔬 How are thyroid hormones released at the molecular level?

🧬 Our Coscia Group uncovered how sortilin binds thyroglobulin through a flexible peptide motif, guiding it along the pathway to hormone release. Using cryo-EM, biophysics and AI-based modelling, the study reveals a mechanism that may apply to many other proteins across the body.

Published in Nature Communications.

Read more 👉

Human Technopole researchers have identified the molecular mechanisms by which the membrane receptor sortilin binds thyroglobulin along its pathway to the release of thyroid hormones within the thyroid gland. The results of the research were published in Nature Communications and highlight that sort...

26/01/2026

🧠 AI works best when it’s shared! The AI4Life project, co-led by our Florian Jug (Computational Biology Research Centre) and Anna Kreshuk (EMBL), earned the top score in the European Commission’s final review.

🔬 The project tackled a key challenge: making AI accessible to non-specialist researchers. Tools like the BioImage Model Zoo let scientists use powerful AI models without advanced coding skills.

The AI4Life project, co-led by Florian Jug (Computational Biology Research Centre at Human Technopole) and Anna Kreshuk (EMBL), received the highest possible score in the European Commission’s final review, recognising its scientific impact and the quality of its achievements in applying artificia...

21/01/2026

🧬 How do blood cancers reprogram the immune system, and how can therapies adapt?

Human Technopole has been awarded a €1.66M FIS grant to push precision immunotherapy forward. Led by our Alice Giustacchini Group, the project brings together molecular, cellular and systems-level analyses to design cell therapies tailored to each disease’s biology.

🤝 Powered by all five HT National Facilities and close collaboration with University College London and Ospedale Pediatrico Bambino Gesù, bridging discovery and care.

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The Giustacchini Group of the Genomics Research Centre of Human Technopole has been awarded a €1.66 million grant from the Fondo Italiano per la Scienza (FIS 2) to advance precision immunotherapy for haematological malignancies. The three-year project, titled “Tailoring Precision Immunotherapy t...

19/01/2026

🚀 Introducing the "HT Seminars: Connecting Discoveries"! A new series bringing leading international researchers to Milan to explore what’s next in life sciences. Across disciplines, perspectives and technologies.

🧬 Join the next talk with Ralf Jungmann (Max Planck Institute of Biochemistry) on DNA nanotechnology and spatial omics.

Calendar & Registrations 👉 https://humantechnopole.it/en/training/external-training/external-seminar-series-2026/

15/01/2026

🧬 How do cells keep messenger RNA levels stable while everything around them changes?

🔬 Our Fabio Marcuccio, Postdoctoral Fellow in the Legnini Group (Genomics Research Centre) has been awarded a Marie Skłodowska-Curie Actions Postdoctoral Fellowship for RNAhome, a project investigating how cells sense and balance mRNA production and removal.

📊 By combining genetic engineering, advanced imaging and mathematical modelling, this research tackles a long-standing question in gene regulation, with future relevance for RNA-based therapies, including mRNA vaccines.

Meet Fabio Marcuccio, Postdoctoral Fellow at the Legnini Group (Genomics Research Centre, Functional Genomics Programme), who has been awarded a prestigious Marie Skłodowska-Curie Actions Postdoctoral Fellowship for the project “Regulation of mRNA homeostasis by poly(A) binding proteins”. The ....

02/01/2026

💡 "We came to them with literally an idea written down on a piece of paper." Professor Sir David Klenerman (University of Cambridge) shares the story behind next-generation sequencing, from a bold concept to a technology that transformed genomics and medicine worldwide.

🎬 In this interview, Prof. Klenerman discusses the technology's unexpected clinical adoption, the challenges of convincing investors without proof of concept, and his current research on neurodegenerative diseases.

Watch the full conversation 👉 https://youtu.be/4MluQqAwqMc

👏 Our thanks to postdocs Azahara Maria Fuentes Trillo (Domínguez Conde Group, Genomics Research Centre, Human Technopole) and Jessica Armida Bertolini (Carninci Group, Genomics Research Centre, Human Technopole) for leading this interview, conducted in the occasion of Prof. Klenerman's keynote lecture at the HT PhD & Postdoc Symposium 2025.

"We came to them with literally an idea written down on a piece of paper." Professor Sir David Klenerman (University of Cambridge) shares the story behind ne...