13/11/2025
University of Nottingham researchers have developed a protein-based gel that can regrow tooth enamel, published in Nature Communications.
The gel extracts calcium and phosphate ions from saliva to encourage mineral growth that merges with existing tooth structure.
Lead author Abshar Hasan stated the gel “promotes the growth of crystals in an integrated and organized manner.”
Lab tests on extracted human molars showed a protective layer formed within weeks, with growth happening “within a week,” according to Professor Alvaro Mata.
The regenerated enamel withstood simulated brushing, chewing, and acidic exposure. Clinical trials are scheduled for early 2026, with commercialization planned through startup Mintech-Bio.
