Haematologica

Haematologica www.haematologica.org publishes novel findings in basic, clinical and translational hematology research. Impact Factor (JCR) 7.116 (7th of 76)

Haematologica/The Hematology Journal (pISSN: 0390-6078, eISSN: 1592-8721, NLM ID: 0417435) publishes peer-reviewed papers across all areas of experimental and clinical hematology. The journal is owned by a non-profit organization, the Ferrata Storti Foundation, and serves the scientific community strictly following the International Committee of Medical Journal Editors (ICMJE, www.icmje.org) recommendations on publication ethics policies for medical journals. Haematologica was founded in 1920 by Adolfo Ferrata

Finding better ways to manage pain in sickle cell disease (SCD): HBI-201, an innovative oral formulation of nitrous oxid...
31/12/2025

Finding better ways to manage pain in sickle cell disease (SCD): HBI-201, an innovative oral formulation of nitrous oxide (N₂O), intended to prevent vaso-occlusive pain in SCD. A new work tests the ability of HBI-201 to block hyperalgesia in preclinical models without causing tolerance or sedation, which is particularly promising and therefore justifies further clinical evaluation.
https://haematologica.org/article/view/12097

Chemo-free treatment for follicular lymphoma: prospective, single-arm, multicenter phase II trial to evaluate obinutuzum...
29/12/2025

Chemo-free treatment for follicular lymphoma: prospective, single-arm, multicenter phase II trial to evaluate obinutuzumab plus ibrutinib in patients with previously untreated advanced-stage follicular lymphoma. Ready for an ALTERNATIVE?
https://haematologica.org/article/view/12104

New study reveals a hidden sugar code inside bone-marrow stroma that could shape leukemia progression. Feng and colleagu...
27/12/2025

New study reveals a hidden sugar code inside bone-marrow stroma that could shape leukemia progression. Feng and colleagues found that lower levels of a specific glycan (bisecting GlcNAc) on stromal cells lead to increased release of TGF-β1, driving macrophages toward a tumor-promoting state. These “reprogrammed” macrophages express PD-L1 and blunt CD8⁺ T-cell responses, potentially helping leukemia cells evade immune attack. Could tweaking glycosylation in the bone marrow microenvironment become a new immunotherapy strategy against myeloid leukemia?
https://haematologica.org/article/view/12071

Treating chronic phase chronic myeloid leukemia in subjects failing to have benefited from other tyrosine kinase inhibit...
25/12/2025

Treating chronic phase chronic myeloid leukemia in subjects failing to have benefited from other tyrosine kinase inhibitors: read here results of a multicenter, retrospective study comparing safety and efficacy of olverembatinib between the recommended dose of 40 mg every other day and a reduced dose of 30 mg every other day.
https://haematologica.org/article/view/12047

The trajectory of measurable residual disease (MRD) recurrence in acute myeloid leukemia patients who achieved MRD-negat...
22/12/2025

The trajectory of measurable residual disease (MRD) recurrence in acute myeloid leukemia patients who achieved MRD-negative remission following induction chemotherapy: a new study analyzes a cohort of 767 patients who had achieved MRD-negative remission within two cycles of induction therapy, suggesting modifications to the ELN-recommended MRD threshold of ≥0.1%, and supporting the redefinition of MRD positivity to any detectable level.
https://haematologica.org/article/view/12103

“Time and space are not conditions of existence, time and space are models for thinking.” Albert Einstein. We can probab...
18/12/2025

“Time and space are not conditions of existence, time and space are models for thinking.” Albert Einstein. We can probably draw an analogy with the dimension of “where” to capture measurable residual disease (MRD) and “when” (timepoint) to check it in acute myeloid leukemia, asking whether different methods and observers perceive these in the same way.
In this issue of Haematologica, Ngai and colleagues describe the prognostic value, with regard to overall survival and incidence of relapse, of different methods of leukemia stem cells quantification across European ELN 2017 risk groups, using data from the HOVON-SAKK132 trial.
https://haematologica.org/article/view/12046

In this issue of Haematologica, Hogan and colleagues report the outcome of the entire cohort of the COG AALL1331 trial w...
16/12/2025

In this issue of Haematologica, Hogan and colleagues report the outcome of the entire cohort of the COG AALL1331 trial with relapsed acute lymphoblastic leukemia (ALL), making this the largest prospective trial reported on relapsed B-cell precursor ALL.
https://haematologica.org/article/view/12137

Guidelines Article: a consensus panel of global leaders with expertise in managing adult acute lymphoblastic leukemia/ly...
12/12/2025

Guidelines Article: a consensus panel of global leaders with expertise in managing adult acute lymphoblastic leukemia/lymphoma (ALL) review the strategies for mitigating and managing asparaginase (ASNase)-associated toxicities in adult ALL patients, with the intent of optimizing treatment outcomes allowing these patients to receive more or all the planned ASNase doses and thereby improve outcomes.
https://haematologica.org/article/view/11989

Review article on hemophilia: sum up of the best available evidence on novel rebalancing agents, their promising clinica...
10/12/2025

Review article on hemophilia: sum up of the best available evidence on novel rebalancing agents, their promising clinical data and remaining challenges. Highlighting the unknowns, and emphasizing the uncertainties that lie ahead, including the thrombotic risk of rebalancing agents, perioperative and bleeding management, availability in low-income countries, efficacy and factor VIII equivalence compared to existing treatments, ideal target populations, and potential application in other hemostatic disorders.
https://haematologica.org/article/view/12200

Perspective article on phosphoinositide 3-kinase (PI3K) pathway inhibitors: scientific rationale, clinical experience, r...
06/12/2025

Perspective article on phosphoinositide 3-kinase (PI3K) pathway inhibitors: scientific rationale, clinical experience, regulatory hurdles, and future developments of PI3K inhibitors for the treatment of lymphoma and chronic lymphocytic leukemia.
https://haematologica.org/article/view/12191

Landmark paper in hematology: the paper published in The New England Journal of Medicine in 2020, demonstrated a signifi...
04/12/2025

Landmark paper in hematology: the paper published in The New England Journal of
Medicine in 2020, demonstrated a significantly lower venous thromboembolism (VTE) recurrence rate of in the apixaban group versus the dalteparin group, leading to a broad implementation of direct oral anticoagulants in the treatment of cancer-associated VTE.
https://haematologica.org/article/view/13009

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