Alchilife

19/05/2020

📍 The paper “Performance of new hypothermic cornea storage media with an antimycotic tablet in comparison to traditional hypothermic media during simulated eye bank processing” has been published in the scientific journal . 💪

The object of the study is the comparison of the performance of two cold corneal storage media during routine eye banking processing procedures for penetrating keratoplasty ( ), Descemet’s stripping automated endothelial keratoplasty ( ) or Descemet’s membrane endothelial keratoplasty ( ).

On one side, the performance of (AL.CHI.MI.A. S.R.L., Italy), a medium containing 2.5 μg/mL of Amphotericin B and on the other side -GS (Bausch & Lomb, USA), the antimycotic-free state-of-art medium for cold corneal storage used in the USA.

Discover the results of the study:

Cornea. 2020 Apr 13. doi: 10.1097/ICO.0000000000002333. [Epub ahead of print]

21/04/2020

🆕 The scientific journal Experimental Eye Research has recently published the paper titled "Safety of silicone oils as intraocular medical device: an in vitro cytotoxicity study”.

The study assesses the of Low Molecular Weight Components ( ) and conventional 1000 cSt silicone oils (SO) with different levels of purification provided by ALCHIMIA Srl using the validated in vitro cytotoxicity test 🧫 by direct contact according to ISO 10993-5 on BALB 3T3 and human-derived ARPE-19 cells.

The results excluded acute direct toxicity on retinal cells of both SO and LMWC as a factor influencing the biocompatibility of the purified SO 1000 cSt intended for intraocular use.

We thank all authors from the Department of Biomedical Sciences of University, the Eye Center Humanitas of , the Ocular Oncology Service of the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan, the Department of Ophthalmology of University, and Alchilife, the R&D department of Alchimia, for their precious help.



Read the study: ▶️https://www.sciencedirect.com/science/article/pii/S0014483520300683

This study aimed to assess the cytotoxic effect of low molecular weight components (LMWC) and conventional silicone oils (SOs) 1000 cSt with different…

17/04/2020

Alchimia, one of the leading European manufacturers of medical devices for Ophthalmic Surgery and Human Tissue Processing, announces the incorporation of Alchilife Srl, an Italian Research & Development company specialized in the ophthalmic field, with great expertise in chemistry, biology, biotechn...

09/03/2020

Every day is a women's day 🌸🌸🌸

20/02/2020

Descemet’s membrane endothelial keratoplasty ( ) and Descemet’s stripping automated keratoplasty ( ) are procedures for the transplantation of diseased endothelium while preserving the healthy part of the . Both techniques are now preferred to the conventional corneal transplantation of the whole cornea. 👩‍⚕️👨‍⚕️
Discover more about the does and don'ts of DMEK
▶️

Ocular Surgery News | Corneal transplantation for endothelial decompensation with otherwise clear corneal stroma has transitioned from full-thickness penetrating keratoplasty to endothelial keratoplasty, which encompasses both Descemet’s stripping endothelial keratoplasty and Descemet’s....

22/01/2020

▶️ To help researchers in the analyses of the great volume and the complexity of biological pictures 🧫, the use of computers 🖥 has become necessary. Discover how the Alchilife team exploited the ImageJ for the quantitative of the endothelial mortality.

The research involved in the field of ophthalmology, especially when focused in testing and in the development of medical devices or procedures that may have an impact on the corneal endothelium’s health, necessitates of a great number of investigations, which sometimes have to face some technical...

17/01/2020

🧫 Truly reliable tests to assess any possible of intraocular have been already developed and validated using the human derived ARPE-19 cell lines. However, the availability of a human retina ex-vivo model is a useful strategy not only to implement the in-vitro results but also to get closer to what happens during .

Detailed information will be presented by J. D’Amato (Alchilfe, Italy) at the guided I of the annual meeting. 🔝

17/01/2020

➡️ Long-term exposure to oxidative stress (e.g. ultraviolet radiation☄️) can lead to ocular disease.

But how does the oxidative stress impact on ?

Join the guided I of the meeting where L. Giurgola (Alchilife, Italy) will provide you with findings obtained from porcine lenses

17/01/2020

🆕 Will the preservation of donor into a cold storage medium supplemented with the amphotericin B and undergoing simulated processes for , , and performs differently from corneas stored in a traditional cold storage medium?

The answers are presented by M. (Miracles In Sight) during the oral presentation session at

16/01/2020

🔝We will be present in for the 32nd Meeting of the European Eye Bank Association Schloss Herrenhausen Hannover

23/12/2019

🎄We wish you a happy season's greetings and a new year of peace and joy.✨✨✨

20/12/2019

🧫 𝐀𝐫𝐞 𝐚𝐥𝐥 𝐩𝐞𝐫𝐟𝐥𝐮𝐨𝐫𝐨𝐜𝐚𝐫𝐛𝐨𝐧𝐬 𝐫𝐞𝐚𝐥𝐥𝐲 𝐬𝐚𝐟𝐞? 🧫

The past unfortunate events pushed all PFCL manufacturers to ensure surgeons about the high purity and safety of their products.
To verify the of some PFCLs available in the market, the Alchilife laboratories has set tests using the validated direct contact methods on the BALB 3T3 and human-derived ARPE-19 cell lines according to the ISO 10993-5 recommendations, as described in the recently published paper of M. , MD, “Evaluation of cytotoxicity of perfluorocarbons for intraocular use by cytotoxicity test in vitro in cell lines and human donor retina ex vivo” in the journal Translational Vision Science & Technology (TVST).

The use of this test detects some interesting surprises.🤔

❗️The analysis showed that some of the tested PFCLs exceeded the maximum limit of 30% cell mortality; but not only. Consistent differences were found among the “not toxic” products, with some of them showing very low toxicity values and others being close or even too close to the acceptable limit of cell mortality.❗️