FLORetina

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FLORetina

Floretina is fed by original content from the main international players active in the field of Retina.

An online platform hosting meetings and forums that offer the possibility to share the state of the art on surgical techniques and technologies.

06/12/2025

In one of the sessions today at Organized by Sophie Bakri, experts shared their insights on wet AMD management. What are the key take aways?

Elodie Bousquet opened the session, highlighting the need for precise early management in neovascular AMD: confirm true neovascular fluid, rule out PCV, choose an appropriate anti‑VEGF, and use a treat‑and‑extend regimen with OCT‑A and, when needed, photodynamic therapy.

Usha Chakravarthy follwed by showing how machine‑learning analysis of SD‑OCT can quantify retinal fluid compartments and highlighted that persistent or fluctuating fluid volumes, especially large PED changes, are key biomarkers linked to worse long‑term visual outcomes.

Mark Breazzano, MD, FACS discussed how treat‑and‑extend regimens are effective in real‑world nAMD care, and may be superior to PRN or fixed‑dose strategies when adherence and loss to follow‑up are considered, however vision loss still occurs and high‑risk type 3 MNV requires close monitoring.

Following this, Sophie Bakri , delivered an insightful talk titled “Beyond VEGF: What’s Here and What’s Coming,” offering a forward-looking perspective on the next chapter of retinal disease management.

Finally, closing this session, Daniela Bacherini showed that in complex eyes with wet AMD, not all fluid reflects neovascular activity, anatomical factors can distort OCT and treatment response, and comorbid ocular diseases often drive prognosis and follow‑up more than the macular neovascularization itself.

06/12/2025

Neuroinflammation in dry AMD with GA took stage in the opening talk of Francesco Bandello at this morning’s Annexon breakfast symposium at , setting the scene for how inflammatory processes might contribute to disease progression and potential future interventions. During the presentation, we saw that C1q‑driven synapse and neuron loss contributes to photoreceptor damage and vision decline in dry AMD with GA, and that blocking C1q in preclinical models can protect synapses, photoreceptors and visual function.
The subsequent presentation by Prof. Paulo Eduardo Stanga EDUARDOthen shifted the focus to the Phase 2 ARCHER study. Stanga summarizedthe results showing that, over 12 months, monthly vonaprument reduced the risk of losing 15 or more ETDRS letters versus sham, with consistent trends across lesion phenotypes, while maintaining a favorable safety profile with no increase in CNV, retinal vasculitis or ION.
As an additional layer of insight to close the session, Daniela Bacherini’s section wrap‑up emphasized the importance of the central 2 mm of the macula, where densely packed cone photoreceptors support fine visual tasks, and how damage in this region appears as loss of the ellipsoid zone on OCT. She highlighted that vonaprument has shown both protection across multiple visual acuity measures and a reduction in ellipsoid zone loss, providing objective structural data that reinforces the visual function outcomes.

06/12/2025

The eye, as a window to the brain. Thanks to the rapid advances in both imaging and data elaboration, it is now possible to look at the retina for signs and symptoms of neurodegenerative, cardiovascular and systemic diseases, from Parkinson’s and Alzheimer’s diseases to diabetes, as well as multiple sclerosis and forms of dementia.

Oculomics is a nascent discipline in early stages of evolution, and it is up to retina specialists in the global scenario to find and evaluate possible markers and predictors to further investigate this new branch of diagnostics.

Yesterday at the Oculomics session at hashtag , chaired by Sharon Fekrat MD FACS FASRS, Imre Lengyel, Sandrine Zweifel, we saw the invaluable contributions of Tunde Peto MD, PhD, Francesco Bandello, MD, FEBO, Giulia Corradetti, gilda cennamo MD, PhD, Angelo Minnella MD, Omer Trivizki MD MBA, as well as Sandrine Zweifel MD, PhD, herself.

“This is all in its very early phases, but if imaging keeps evolving at this pace we will soon be able to have some invaluable information on our hands,” Bandello said. “The imaging that we have in ophthalmology is at the nanometer level, observing lesions and small changes currently not replicable on MRI. We can see changes in the layers in the retina that can be telltale signs of neurodegenerative diseases,” Peto added.

05/12/2025

Acting against the myopia epidemic is an urgent need. However, to correctly address this issue it is important to deeply understand the mechanism behind myopic onset and how to act on it.

During the Myopia Progression symposium today at , a panel of international experts of the anterior and posterior segment, as well as paediatric ophthalmologists, gave important insight on the pathogenetic causes of myopia and what can be done to delay the onset and slow its progression.

During the sessions many interesting topic were discussed, starting with Serge Resnikoff MD, PhD, And Francine Behar-Cohen MD, PhD, highlighted the link between high myopia and light.

Gemmy Cheung, MBBS, discussed about Retinal inflammation and atrophy in pathologic myopia, followed by a presentation by JOSE MARÍA RUIZ MORENO MD, PhD on traction myopic maculopathy. The session continued with the presentation of luca buzzonetti MD, on 0.01% Atropine eyedrops and Leonardo Mastropasqua, MD on refractive surgery. Resnikoff took again the podium to talk about myopic epidemiology in Europe.

The last phase of the symposium was dedicated to optical defocus strategies, with Optometrist Ahrne Olendorf from Zeiss bringing a presentation on myopia control with CARE spectacle lenses, and finally Raffaele Parrozzani, MD, PhD FEBO on the reduction of myopia of prematurity with EssilorLuxottica proprietary H.A.L.T. technology.

05/12/2025

A teacher of a whole generation of ophthalmologists, an illustrious and beloved Professor, a dearly missed husband, father and friend.

To honour the memory of Bruno Lumbroso, the important Lectureship at the FLOretina-ICOOR meeting has been renewed for the year 2025 and assigned to Eric Souied MD, PhD, (Head of the Ophthalmology Department at Intercommunal Hospital of Créteil and Henri Mondor Hospital, and Professor in Ophthalmology, University Paris Est.).

At today's lecture, Quan Đông Nguyễn, MD, MSc and Giuseppe Querques MD, PhD, had the opportunity to introduce Prof. Souied with a heartfelt presentation on his life and achievements.

“Without Bruno Lumbroso we would not have the OCTA. He changed ophthalmology forever,” Souied recalled.
For his Lecture, Professor Souied presented insights from his 25-year experience in the development of gene therapy for wet AMD, outlining the current state of the field and the promising future of a therapy that is going to reshape medical retina in the near future.

Bruno Lumbroso Lecture Committee members:
Marco Rispoli, Prof. Dr. med. Albert Augustin, Francesco Bandello, Amani Fawzi, gaudric alain, David Huang

05/12/2025

FLORetina-ICOOR 2025 officially opened yesterday afternoon with an inspiring reminder of why this community gathers: to advance retinal care for the growing number of patients worldwide.

As noted in the opening session, numbers speak loudly - 2.6 billion people affected by myopia, 150 million by diabetic retinopathy, and a future where these figures are expected to double. Yet innovation is rising to meet the challenge: over 120 active gene therapy trials, increasingly refined surgical instruments, and the transition from microscopes to fully digital surgery. We restore sight, and we are here because we want to change the world.

Set in Florence, the birthplace of humanism, art, and scientific thought, the Opening Session connected ophthalmology with artistic vision.
Speakers reflected on how AI is transforming retinal imaging, how retinal disease has shaped artistic expression, and how modern art has evolved from static object to a dynamic experience, mirroring the evolution of ophthalmic practice itself.

With participants from all around the world, FLORetina, RetinaFutura and EYENOVATE come together as a global meeting point for science, innovation, collaboration, and culture.

Just like art builds on its foundations to continually evolve, so does the practice of retinal care. And here in Florence, that future takes shape.

04/12/2025

closes its sessions with a spotlight on the next generation of innovators, as rising companies and startups showcased a wave of groundbreaking technologies set to shape the future of ophthalmic care.

From robotic operating room concepts to next-gen imaging platforms, novel delivery systems, bioresorbable drug-delivery devices, and minimally invasive ophthalmic fluid delivery tools, the session highlighted the incredible range of ideas emerging across the field.

We also saw cloud-based AMD management platforms, and even experimental light-based combination therapy for early AMD, multispecific antibodies, high-precision home perimetry tools, and handheld OCT imaging designed for newborn and paediatric patients.

A true panorama of creativity and progress—showcasing how new enterprises are driving the future of both anterior and posterior segment surgery.

04/12/2025

🌐Global shifts—from the post-pandemic landscape to economic instability, geopolitical tensions, and the international stakeholders like China—continue to reshape how innovation moves across borders.

At one of the afternoon sessions explored the “Influence of Geopolitical Climate in Biotech Innovation and Cross-Border Collaboration: What’s at Stake for the Future”. Experts discussed how the biotech sector is navigating this complexity with resilience and adaptability.

Chaired by Ram Palanki, PharmD, and Daniel Ting, MD, PhD, experts examined how capital flows, risk management, and strategic partnerships can sustain innovation in an increasingly uncertain global setup.

04/12/2025

We resume the this afternoon with a high intensity high tech session.

During this session chaired by Professor Ursula Schmidt-Erfurth MD, Dr. Diana Do, MD and Dr. Lejla Vajzociv MD. International leading surgical companies such as Alcon, Bausch + Lomb, ZEISS Vision, Heidelberg Engineering, BVI Medical, Topcon Healthcare, TowardPi, Optos and BEYEONICS™ Vision showcased the latest and upcoming technologies on the market.

04/12/2025

closes off the morning sessions spotlighting different challenges for different healthcare systems.
During the session on "Shaping the Future: Regulatory Perspective on Innovation session," chaired by Stanislao Rizzo MD, and Kourous Rezaei, MD, the session brought a panel of experts from leading regulatory bodies to share their views in the regulatory environment, sharing their insights on improving drug and treatment accessibility and how to better align with physicians' and patients' needs and expectations.

04/12/2025

Another key session has just finished at - “Translating Science Into Products in a Complex Global Ecosystem: Large Company Showcase."

Chaired by Charles Wykoff and Carl Regillo, speakers from different industry leading companies like Roche, AbbVie, and Boehringer Ingelheim highlighted strategies for collaboration, partnerships, and efficiency across a complex global landscape, highlighting how promising science can translate into real-world products.

04/12/2025

The next session, “Retina Rare Diseases”, highlighted new data on the treatment and management of rare retinal conditions.

Chaired by Prof. Paulo Eduardo Stanga and Prof. Francesca Simonelli, the panel shared cutting-edge insights from international researchers and leading biotech & gene therapy companies.

These advances bring renewed hope for patients with Stargardt disease, Usher Syndrome, and Retinitis Pigmentosa.

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