Fondazione Italiana Fegato - FIF Onlus

22/12/2025

Are you a Filipino Citizen?
If you’re passionate about advancing health research and ready to take the next big academic step, we encourage you to apply for a PhD in Molecular Biomedicine funded by DOST PCHRD

The three-year doctoral program will be conducted in Trieste, Italy, in collaboration with the Università degli studi di Trieste and Fondazione Italiana Fegato (FIF) — a global hub for cutting-edge biomedical research 🇮🇹🧬

ℹ️ Check your eligibility here: bit.ly/2026PhD_Italy

📩 Apply here: https://bit.ly/PCHRD_SIS
📌 Application deadline: 2 February 2026

🎄✨ A holiday cheer for future scientists! ✨🎄

This Christmas season, unwrap an opportunity to pursue your PhD in Molecular Biomedicine and build world-class expertise in liver research.

The three-year doctoral program will be conducted in Trieste, Italy, in collaboration with the University of Trieste and Fondazione Italiana Fegato (FIF)—a global hub for cutting-edge biomedical research 🇮🇹🧬

If you’re passionate about advancing health research and ready to take the next big academic step, we encourage you to apply!

📌 Application deadline: 2 February 2026
📩 Apply here: https://bit.ly/PCHRD_SIS
ℹ️ Learn more: bit.ly/2026PhD_Italy

Make this season one of growth, discovery, and new beginnings. 🌟
Your PhD journey could start with this holiday surprise!

19/12/2025

19/12/2025

🧬 Lo studio di un gruppo internazionale di ricercatori, guidati dal docente dell'Università di Udine Gianluca Petris, su “Science”

Trasferire, modificare e sostituire interi cromosomi umani mantenendo intatta la loro struttura: questa la ricerca che rappresenta una svolta decisiva per la biologia sintetica e generativa e per le future terapie genetiche avanzate.

🔬 La prosecuzione e l’espansione dello studio in Italia sono portate avanti dal docente presso la Fondazione Italiana Fegato - FIF Onlus e l’Ateneo, grazie al sostegno di finanziamenti competitivi quali il My First AIRC Grant (AIRC) e il programma PNRR – Giovani Ricercatori.

Leggi la notizia completa su Qui.Uniud ➡️ https://bit.ly/RicercaInternazionaleGianlucaPetris

UK Research and Innovation | Wellcome Trust

12/12/2025

Christmas spirits are high as Fondazione Italiana Fegato (FIF) celebrates the holidays with our annual Christmas Party 🎄🎁❄️
We give the warmest wishes to you and your families that you may have a joyous Christmas season.
And may your 2026 be filled with health, success, and love!

11/12/2025

Intervista a Gianluca Petris a Trieste in diretta, su Telequattro Trieste

E' possibile ingegnerizzare la ? Cosa significa in pratica?

Scoprilo qui: https://youtu.be/Q-M-OqErcM0?si=JZv0Zb88pNMghhUC&t=1741

10/12/2025

Welcome Junally to the FIF laboratories. We are pleased to have you joining the team as a new PhD researcher, wishing you a productive and successful work ahead.
Thank you DOST PCHRD for your support!

Meet Ms. Junally Layson, a new DOST-PCHRD Scholar under the Foreign Graduate Scholarship Program with the University of Trieste and Fondazione Italiana Fegato.

She began her PhD in Molecular Biomedicine program in Italy last November, and is enthusiastic in contributing to liver research as a Filipino researcher. 🇵🇭✨

Do you want to follow the same path? Stay tuned for the opening of the 2026 Call for Applications. ;)

10/12/2025

Greetings! My name is Junally Jerca Mae Layson, a graduate of the Master of Science in Molecular Genetics and Genetic Engineering program at Mahidol University Thailand. I am currently in my first year of the PhD program in Molecular Biomedicine at the Università degli studi di Trieste, supported by the DOST PCHRD scholarship. My research is conducted at the Fondazione Italiana Fegato (FIF) under the supervision of Prof. Dr. Claudio Tiribelli and Dr. Pablo Giraudi.

👉 My project aims to bridge omics and diagnostics by studying the key genes and tiny “microproteins” that influence liver fibrosis, an important process in chronic liver disease. By exploring one of Europe’s largest liver transcriptomic datasets, our team seeks to uncover the gene networks driving fibrosis and identify new biomarkers for earlier detection of liver damage. These advances have the potential to significantly improve how doctors diagnose and treat liver disease, leading to timelier interventions and better patient outcomes. We will validate our discoveries using real patient samples and develop a new assay to measure microproteins, addressing a current diagnostic gap. 🔬🧫

🧬 I’m incredibly grateful for the opportunity to learn from experts and be part of an international scientific community. As a Filipina scholar, I hope to contribute, however small, to the field of translational research and help bring scientific insights closer to real-life medical solutions.

05/12/2025

An international research team from the MRC Laboratory of Molecular Biology and the Wellcome Sanger Institute in Cambridge, led by Gianluca Petris—Principal Investigator of the Genome Engineering & Biotechnology Unit at the Fondazione Italiana Fegato and Associate Professor at the Università degli Studi di Udine —has achieved an unprecedented breakthrough in genome engineering: the transfer, engineering, and replacement of entire human chromosomes while preserving their structural and functional integrity.

Published in Science , the study represents a major advance in synthetic and generative biology and establishes a new paradigm for chromosome-scale genome engineering with direct relevance for advanced genetic therapies. The authors demonstrate that intact human chromosomes can be transferred between cells, modified without damage, and reintroduced into recipient human cells. Endogenous chromosomes can be selectively removed and replaced with engineered counterparts, completing for the first time a full chromosome transplantation cycle with unprecedented genomic fidelity.

By enabling genome manipulation at chromosome scale, this approach overcomes intrinsic limitations of conventional genome-editing technologies such as CRISPR-Cas and allows causal analysis of the human genome as an integrated system. The platform supports systematic investigation of large regulatory regions, non-coding “dark DNA,” three-dimensional chromatin organization, and chromosomal alterations associated with cancer and aging.

The experimental work was conducted entirely in the United Kingdom with support from the Medical Research Council (MRC), the Wellcome Trust , and a Marie Skłodowska-Curie Postdoctoral Fellowship. The continuation and expansion of this research are currently being pursued in Italy at the Italian Liver Foundation and the University of Udine, supported by competitive funding programs including the My First AIRC Grant (Fondazione AIRC per la Ricerca sul Cancro ) and the PNRR – Young Researchers initiative.

Full article here: https://www.science.org/doi/10.1126/science.adv9797

05/12/2025

🚨Trasferire, modificare e sostituire interi cromosomi umani senza alterarne la struttura

Uno studio pubblicato su Science da un gruppo internazionale di ricercatori del MRC Laboratory of Molecular Biology e del Wellcome Sanger Institute di Cambridge, guidato da Gianluca Petris (Fondazione Italiana Fegato e Università degli Studi di Udine), segna una svolta per la biologia sintetica e le future terapie genetiche.

I ricercatori hanno sviluppato una tecnologia che consente di trasferire cromosomi umani interi tra cellule, modificarli in speciali “cellule fabbrica” e reintrodurli nelle cellule bersaglio, mantenendo intatta la struttura del . È stato così possibile sostituire completamente un cromosoma umano con uno ingegnerizzato, completando per la prima volta un ciclo di trapianto cromosomico con altissima fedeltà genomica.

Questo approccio supera i limiti dell’editing genomico tradizionale, permettendo di studiare il genoma umano come un sistema integrato e aprendo nuove prospettive nello studio di invecchiamento, cancro e “DNA oscuro”. In prospettiva, la tecnologia potrà favorire lo sviluppo di cromosomi sintetici e di terapie genetiche avanzate per malattie complesse e rare.

La ricerca è stata condotta nel Regno Unito con il supporto di MRC, Wellcome Trust e Marie Skłodowska-Curie Actions e prosegue oggi in Italia presso la Fondazione Italiana Fegato e l’Università di Udine grazie a finanziamenti Fondazione AIRC per la Ricerca sul Cancro (My first AIRC Grant) e PNRR.

Leggi l'articolo qui: https://www.science.org/doi/10.1126/science.adv9797

03/12/2025

Il Piccolo parla del Progetto Blue