18/11/2020
Come funziona il CBD? 🔬
Un interessante approfondimento sul suo ruolo in oncologia al link di seguito!
https://doi.org/10.3390/cancers12113203
A great review of CBD’s mechanism of action and its potential applications in cancer therapy:
“CBD has demonstrated robust anti-proliferative and pro-apoptotic effects on a wide variety of cancer types both in cultured cancer cell lines and in mouse tumor models.
The anti-tumor mechanisms vary based on tumor types, ranging from cell cycle arrest to autophagy, to cell death, or in combination.
CBD can also inhibit tumor migration, invasion, and neo-vascularization, suggesting that CBD not only acts on tumor cells but can also affect the tumor microenvironment, for example by modulating infiltrating mesenchymal cells and immune cells.
The dependency of CBD on the endocannabinoid receptors, CB1 and CB2, or the TRPV family of calcium channels, also varies, suggesting that CBD may have multiple cellular targets and/or different cellular targets in different tumors.
Mechanistically, CBD seems to disrupt the cellular redox homeostasis and induce a drastic increase of ROS and ER stress, which could then exert the cell cycle arrest, autophagy, and cell death effects.
For future studies, it is crucial to elucidate the interplays among different signaling transduction pathways, such as ROS, ER stress, and inflammation, in order to better understand how CBD treatment disrupts cellular homeostasis in both tumor cells as well as infiltrating cells, leading to cancer cell death and inhibition of tumor migration, invasion, metastasis, and angiogenesis.”
Seltzer ES, Watters AK, MacKenzie D Jr, Granat LM, Zhang D. Cannabidiol (CBD) as a Promising Anti-Cancer Drug. Cancers (Basel). 2020 Oct 30;12(11):E3203. doi: 10.3390/cancers12113203.
