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Nuclide Notes 🩻 Nuclear Medicine & Hybrid Imaging
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☢️ Sternal infection ☢️ 51-year-old male with history of CABG and post operative sternal dehiscence and wound infection....
14/01/2026

☢️ Sternal infection ☢️ 51-year-old male with history of CABG and post operative sternal dehiscence and wound infection. Sternal reconstruction and fixation was done; however, over the next few weeks, he developed a draining sinus from the sternal wound. FDG PET images clearly show hypermetabolic soft tissue collection with indistinct margins and gas locales centered at the midline sternotomy, with trans-sternal extension both anteriorly to the subdermis and posterior into the anterior mediastinum approaching the pericardium. The regional fat planes are infiltrated with fat stranding and increased opacification. There is also hypermetabolic activity in the sternoclavicular joint spaces with bone resorption of the manubrial and clavicular ends of sternoclavicular joints suggestive of underlying infection.
🗓 The probability of median sternotomy complications is around 5% with mortality rate reaching up to 80%. Complications can be divided into presternal (cellulitis, abscess, sinus fistula), sternal (dehiscence, osteomyelitis), mediastinal (abscess, mediastinitis). Variable SN and SP have been reported for FDG PET/CT in MSK infections. For example the reported the SN and SP in chronic osteomyelitis is 92%, in diabetic foot (vs. Charcot joint) 74% and 91%. Nevertheless, sternal infections share a similar process as in a different anatomical region.

🦴 A solitary lumbar focal area of intense uptake, mistakenly reported as metastasis in prior scan in a patient with pros...
13/01/2026

🦴 A solitary lumbar focal area of intense uptake, mistakenly reported as metastasis in prior scan in a patient with prostate cancer (PSA was 0.018).

☢️ On SPECT/CT, uptake is centered at the L2 vertebral body corresponding to endplate depression and schmorl’s node rather than sclerotic deposit.

Planar imaging has poor specificity, findings should always be correlated with anatomical imaging, especially when the clinical context does not fit.

☢️ Dermatofibrosarcoma Protuberans ☢️ Lower anterior chest wall subdermal well defined soft tissue mass of moderate FDG ...
12/01/2026

☢️ Dermatofibrosarcoma Protuberans ☢️ Lower anterior chest wall subdermal well defined soft tissue mass of moderate FDG uptake interspersed with fat streaks, and dermal thickening. There is adjacent exophyting and well defined dermal soft tissue lesion of mild FDG uptake with regular borders, extending to the underlying subdermal region. Furthermore, there are multifocal dermal thickening along the distance between the two lesions. Biopsy revealed Dermatofibrosarcoma Protuberans.
🗓 Dermatofibrosarcoma Protuberans Is a low-grade malignant tumour arising from dermal and subnormal tissues and is the most common cutaneous sarcoma (although overall still quite rare). It is most commonly found at the trunk and proximal extremities. The tumor occurs in patients of all ages, with the highest frequency occurring between ages 20-50 years. Males are slightly more commonly affected than females. Most common site of metastases (

☢️ Chloroma ☢️ FDG PET/CT scan shows hypermetabolic right parietal and left occipital lobes hyperdense lesions, nodular ...
11/01/2026

☢️ Chloroma ☢️ FDG PET/CT scan shows hypermetabolic right parietal and left occipital lobes hyperdense lesions, nodular hepatic contours with global hypermetabolic poorly defined geographical multifocal areas occupying the hepatic parenchyma. Hypermetabolic left adrenal gland obscured nodular density, concentric bowel wall thickening involving the distal duodenal D3/intraperitoneal D4 and proximal jejunum with surrounding fat infiltration and edematous changes. Hypermetabolic supra and infra diaphragmatic lymph nodes, numerous hypermetabolic lytic deposits spread throughout the axial and appendicular skeleton with regions of moth-eaten pattern and cortical destruction. The deposits in the right sacrum and left ilium are destructive associated with sacral fracture and soft tissue component.
🗓️ Myeloid sarcoma or chloroma is a rare extramedullary myeloid tumor made up of myeloid precursor cells. Can arise of myelodysplastic syndromes or myeloproliferative neoplasms (AML most common, CML, PCV, myelofibrosis) and almost any tissue can be involved in the disease. FDG PET/CT is good tool for mapping the disease, detecting occult extra medullary lesions, guiding biopsy, and treatment planning.

☢️ Proximal tibial stress fracture ☢️ in a 16-year-old male with inconclusive X-ray findings. SPECT imaging shows a foca...
09/01/2026

☢️ Proximal tibial stress fracture ☢️ in a 16-year-old male with inconclusive X-ray findings. SPECT imaging shows a focal area of intense tracer uptake in the proximal tibia. Fused SPECT/CT images show an intense focal area corresponding to linear band of sclerosis in the proximal tibia.
🗓️ While distal and mid tibia account for 50% of fractures, proximal tibial fracture is rare and sometimes can be confused with other type of fractures or pathology. Swipe left for a fracture assessment summery in bone scans.

🫀 SPECT Myocardial Perfusion Case🗓 Stress-rest SPECT/CT shows a large, completely reversible perfusion defect in the ant...
06/01/2026

🫀 SPECT Myocardial Perfusion Case

🗓 Stress-rest SPECT/CT shows a large, completely reversible perfusion defect in the anterior, inferior and inferolateral walls (base to apex), with normal perfusion elsewhere.
📊 SSS: 24 | SRS: 1 | SDS: 23 | TPD: 18%
Gated images show hypokinesia in the inferior and septal regions with normal LV function (LVEF: 50%).

📝 Interpretation:
✅ Significant reversible stress induced ischemia
✅ Hypokinesia in the inferolateal region
✅ Normal systolic function
✅ Dilated LV cavity

❓Which PET viability pattern predicts the highest likelihood of LV functional recovery after revascularization?         ...
05/01/2026

❓Which PET viability pattern predicts the highest likelihood of LV functional recovery after revascularization?

🧠 Mini-Masterclass | Gastric Anatomy on FDG PET/CT This carousel maps the stomach step-by-step (cardia → fundus → body →...
04/01/2026

🧠 Mini-Masterclass | Gastric Anatomy on FDG PET/CT

This carousel maps the stomach step-by-step (cardia → fundus → body → antrum → pyloric canal → pylorus) so you can name the segment confidently and avoid false alarms.

Quick reporting pearls:
✅ Always localize uptake to a gastric segment (not just “stomach”).
✅ Uptake: focal vs diffuse? mucosal vs mural? does CT show wall thickening?
✅ Perigastric fat plans: clear vs. nodular infiltration or fat stranding.

📌 Save this for your next PET/CT read.
🧩 Quiz: Which segment do you mislabel most often — cardia vs fundus or antrum vs pylorus?

☢️ Osteochondroma ☢️ FDG PET/CT scan shows a well defined pedunculated bony lesion arising from the left 7th rib anterio...
03/01/2026

☢️ Osteochondroma ☢️ FDG PET/CT scan shows a well defined pedunculated bony lesion arising from the left 7th rib anteriorly with medullary continuity and projecting posteriorly indenting the pericardial surface. There is no associated cortical destruction or soft tissue component, pneumothorax, pleural effusion or parenchymal lung changes. Osteochondromas are non FDG avid unless there is malignant transformation, in bone scan there is increased tracer uptake during the growth period until they show normal bone activity. Presence of activity in adulthood should raise the concern of underlying complication such as malignant transformation or fracture.
🗓 Osteochondromas (Exostosis) are usually asymptomatic benign lesions (10-15%) that can qpresent at any age. They can be symptomatic if there’s a fracture , if causing mass effect or associated with malignant transformation (1%). Most commonly they arise in the lower limbs (30% in femurs), upper limbs and in the posterior elements of the spine. Osteochondormas of the ribs are rare and almost always arise near the anterior end of the rib.

☢️ FDG PET/CT scan shows suppressed LV FDG uptake with a focal area of moderate FDG uptake in the apex and anterior apic...
02/01/2026

☢️ FDG PET/CT scan shows suppressed LV FDG uptake with a focal area of moderate FDG uptake in the apex and anterior apical segment which is deviating from the physiological expected pattern of uptake. SPECT/CT MPI show fixed severely reduced perfusion abnormality in the apex.
🗓 Myocardial FDG uptake can follow a continuum that mirrors regional energy demand, starting from minimal or absent activity, then small foci near the aortic root, progressing to involvement of the basal ring, then extending gradually along the ventricular walls toward the apex, with the apical septum typically being the last regions to show uptake. Here we see global LV suppression with a focus of moderate FDG uptake in the apex and anterior apical segment, which does not fit this expected physiological gradient. This finding on FDG PET should raise the suspicion of underlying hibernating myocardium/ischemia.

☢️ Meningioma ☢️ 18F-PSMA scan shows hyperdense extra axial mass with coarse calcifications of low PSMA expression in th...
01/01/2026

☢️ Meningioma ☢️ 18F-PSMA scan shows hyperdense extra axial mass with coarse calcifications of low PSMA expression in the left frontal lobe. The appearance and location are most consistent with a PSMA avid meningioma (incidental finding) rather than metastatic disease.
🗓️ In PSMA PET scans, meningiomas are well recognized pitfall of intracranial PSMA avid lesions, typically appearing as a focal low to high PSMA avid dural based lesion/mass. The avidity is largely related to PSMA expression in the tumor’s neovasculature and endothelial cells. Unregulated PSMA expression in meningiomas is correlated with higher grades tumors and incidence of recurrence.

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