京都大学医学部附属病院　免疫・膠原病内科

31/10/2025

2025年10月24日(金) ～ 2025年10月29日(水)にアメリカリウマチ学会が開催され、笹井恒雄診療助教がplenary sessionで発表しました！また、小川惇史大学院生がポスター発表をしました！

22/09/2025

別役翼大学院生の論文がPLoS One誌に掲載されました！

Betsuyaku T, Akizuki S, Liu Y, Morinobu A. Activated human B cells produce phospholipase D4-containing extracellular vesicles. PLoS One. 2025 Aug 14;20(8):e0329832. doi: 10.1371/journal.pone.0329832. PMID: 40811510; PMCID: PMC12352752.

Phospholipase D4 (PLD4) is an intracellular exonuclease implicated in immune regulation via nucleic acid degradation. While public proteomic databases indicate the presence of PLD4 in human plasma, its mode of extracellular release remains unclear. This study demonstrates that activated B cells secr...

09/09/2025

中坊周一郎特定助教がAPLAR2025でBest Abstract Awardを受賞しました！

また、APLAR2025 Travel Award on JCRについて、当科医師が多数受賞致しました。
相谷祐輝後期修練医（現北野病院）、大西輝特定講師（リウマチセンター）、笹井恒雄診療助教、白柏魅怜特定病院助教、辻英輝助教、中山洋一医員、吉田常恭医師（留学中）

https://www.ryumachi-jp.com/jcr_wp/media/2025/07/APLAR2025_TA_JCR_WEB.pdf

14/08/2025

留学中の吉田常恭医師の論文がArthritis Research & Therapy誌に掲載されました！

Yoshida T, Murotani Y, Murata K, Imai H, Iwasaki T, Nakayama Y, Katsushima M, Shirakashi M, Nakashima R, Watanabe R, Murakami K, Yoshifuji H, Morinobu A, Hashimoto M. Roles of JAK-STAT signaling and granulocyte-macrophage colony-stimulating factor in the development of osteitis and bone microstructure changes in rheumatoid arthritis. Arthritis Res Ther. 2025 Jul 10;27(1):143. doi: 10.1186/s13075-025-03597-6. PMID: 40640953; PMCID: PMC12243279.

Background Osteitis on magnetic resonance imaging (MRI) and bone microstructure changes (BMC) on high-resolution peripheral quantitative computed tomography (CT) are the earliest signs of arthritis, preceding the development of bone erosion on X-ray in rheumatoid arthritis (RA). Recently, a Janus ki...

13/08/2025

留学中の内藤遼太医師の論文がPLoS One誌に掲載されました！

Naito R, Taniguchi M, Onizawa H, Nakajima T, McCracken K, Mori M, Hiwa R, Nakamura T, Onishi A, Matsuda S, Morinobu A, Hirose S, Shinkawa Y, Umehara H, Tanaka M. Upper extremity joint tenderness as a practical indicator for assessing presenteeism in rheumatoid arthritis patients: A cross-sectional observational study. PLoS One. 2025 Jun 5;20(6):e0318047. doi: 10.1371/journal.pone.0318047. PMID: 40471982; PMCID: PMC12140210.

Objective Rheumatoid arthritis (RA) causes chronic polyarthritis and joint dysfunction, reducing work productivity. This reduction is mainly due to presenteeism, characterized by impaired work performance despite being present at work. This study aims to investigate the impact of specific joint invo...

10/07/2025

福村麻綾先生（北野病院）の症例報告がRheumatology (Oxford)誌に掲載されました！

Fukumura M, Kitagori K, Sasai T, Hiwa R, Tsuji H, Shirakashi M, Akizuki S, Nakashima R, Yoshifuji H, Morinobu A. A case of systemic lupus erythematosus onset in sisters with Lynch syndrome carrying MSH2 mutation. Rheumatology (Oxford). 2025 Jun 5:keaf310. doi: 10.1093/rheumatology/keaf310. Epub ahead of print. PMID: 40471715.

Maaya Fukumura, Koji Kitagori, Tsuneo Sasai, Ryosuke Hiwa, Hideaki Tsuji, Mirei Shirakashi, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Akio Morinobu;