TOMOCUBE

03/02/2026

📍 LMA2026 — Good Morning from the Symposium Floor

Light Microscopy Australia’s 5th National Symposium is officially underway. We’re excited to be here together with our partner, Scitech, kicking off a full week of conversations around live imaging, advanced light microscopy, and the future of image analysis.

Looking forward to connecting with the community and sharing how label-free, quantitative 3D holotomography complements today’s imaging workflows.

Let the week begin!

02/02/2026

We’re excited to share that Tomocube will be joining SLAS 2026! 🎉

At this year’s show, we’ll be highlighting how HT-X1 Plus supports 𝗵𝗶𝗴𝗵-𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁, 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗶𝗼𝗻-𝗿𝗲𝗮𝗱𝘆 𝗵𝗼𝗹𝗼𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝘆—designed for labs that need speed, consistency, and scalable data generation. Our focus is on building an efficient data factory: smart scheduling, reliable auto-focus, and streamlined workflows that help teams acquire large, reproducible datasets with less manual effort.

If you’re working in high-throughput screening, workflow automation, or advanced imaging, come see how semi-automation can make a real difference in day-to-day experiments.

📍 See you at SLAS 2026—let’s talk automation, efficiency, and better data.

30/01/2026

🎉 Congratulations to the Markus Basan Lab on their new Cell publication.

We’re proud to see Tomocube holotomography featured as a quantitative measurement method in the newly published study.

In this work, the authors combined multiple advanced approaches to investigate how cells sense tissue density and mechanical pressure. Holotomography was used to independently quantify cellular biomass density, providing 3D volume reconstruction and refractive-index–based mass measurements that supported the paper's core biophysical conclusions.

This study highlights how holotomography can contribute to:
→ Quantitative measurement of intrinsic cellular properties
→ Label-free analysis of live-cell physical states
→ Complementary validation alongside other high-end biophysical techniques

We’re excited to see holotomography supporting this level of fundamental discovery.

Go to the article: https://www.cell.com/cell/abstract/S0092-8674(25)01253-X

📩 For scientific inquiries or collaboration discussions: info@tomocube.com

Cells in tissues need to know when to start growing and when to stop growing to quickly heal wounds but prevent tumorous overgrowth. Membrane potential allows cells to sense physical forces, including those from neighboring cells, and thereby regulates growth.

28/01/2026

We’re excited to be heading to — Light Microscopy Australia’s 5th National Symposium!

📅 February 2-6, 2026

A full week dedicated to live imaging, advanced techniques, and the future of image analysis.

We’re looking forward to exchanging ideas, discovering new methods, and sharing how label-free, quantitative 3D holotomography fits into the evolving imaging ecosystem.

See you there!

27/01/2026

📢 New Holotomography Video

Discover the inner architecture of the 𝗲𝗺𝗯𝗿𝘆𝗼𝗻𝗶𝗰 𝗺𝗼𝘂𝘀𝗲 𝗰𝗼𝗰𝗵𝗹𝗲𝗮 — without labels, staining, or thin sectioning.

This video showcases label-free 3D imaging of intact embryonic mouse cochlear tissue using holotomography (HT), revealing fine anatomical structures such as hair cell rows, blood vessels, and neural features based purely on intrinsic optical contrast.

Why holotomography for 𝘁𝗶𝘀𝘀𝘂𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗴?

🔹 Direct observation of tissue's microstructure
🔹 Reveal structures that are hard to label
🔹 Preserve imaging samples for downstream analysis
🔹 Simplified experimental workflow

YouTube link: https://www.youtube.com/watch?v=w0WQJ535i2g
📩 Learn more about holotomography: https://www.tomocube.com
📧 Contact us: info@tomocube.com

#토모큐브 #달팽이관

22/01/2026

A small moment, but a meaningful one for our team.

We were genuinely moved to receive these pictures from Prof. Chan-gi Pack (Asan Medical Center / Ulsan University College of Medicine), holding framed holotomography images of his own samples, with a bright smile that says more than words.

Prof. Pack has been a valued collaborator and long-time user of our technology. His trust, engagement, and ongoing dialogue with our team represent the kind of partnership we deeply value.

Thank you for the continued collaboration and support. It truly means a lot to us.

16/01/2026

🎉 Congratulations to the authors from The University of Texas MD Anderson Cancer Center on their exciting new study published in Cell Reports Medicine, revealing a previously unrecognized metabolic vulnerability in triple-negative breast cancer (TNBC).

This study reveals a novel 𝗺𝗶𝘁𝗼𝗰𝗵𝗼𝗻𝗱𝗿𝗶𝗮𝗹 𝗾𝘂𝗮𝗹𝗶𝘁𝘆-𝗰𝗼𝗻𝘁𝗿𝗼𝗹 𝗽𝗿𝗼𝗴𝗿𝗮𝗺 𝗶𝗻 𝗧𝗡𝗕𝗖 𝗰𝗲𝗹𝗹𝘀, where damaged mitochondria are cleared through extracellular vesicles—working alongside classical mitophagy to support cancer cell survival. Importantly, disrupting this pathway leads to mitochondrial collapse and cancer cell death, highlighting a promising therapeutic opportunity.

🧠Label-free 3D played a key role in this work, enabling researchers to directly observe mitochondrial remodeling and cellular stress responses over time. By providing quantitative, longitudinal insight into live-cell dynamics—without staining or perturbation—holotomography helped reveal cellular behaviors that are difficult to capture with conventional imaging.

Read the full article: https://doi.org/10.1016/j.xcrm.2025.102478

15/01/2026

👀 𝗚𝘂𝗲𝘀𝘀 𝘄𝗵𝗼 𝗵𝗮𝘀 𝘁𝗵𝗲 𝗯𝗲𝘀𝘁 𝘀𝗲𝗮𝘁 𝗮𝘁 𝗙𝗟𝗔𝗜𝗥 𝟮𝟬𝟮𝟲 𝗮𝘁 𝗨𝗖 𝗜𝗿𝘃𝗶𝗻𝗲?

It’s the 𝗛𝗧-𝗫𝟭 𝗺𝗶𝗻𝗶 — front-row access to great science and even better conversations.

We’ve been having fantastic discussions with researchers exploring how label-free, quantitative 3D holotomography can complement fluorescence workflows — especially for organoids and advanced 3D models.

The mini didn’t just sit there either.

It hosted 𝗹𝗶𝘃𝗲 𝘀𝗮𝗺𝗽𝗹𝗲 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘀𝗲𝘀𝘀𝗶𝗼𝗻𝘀, generating real data on-site and sparking serious interest from visitors who brought their own samples to try.

We’ll be here through Thursday (Jan 15) — Visit our booth and demo area to explore:
🔹 Correlative holotomography + spinning disk confocal
🔹 Quantitative RI-based insights for phenotype interpretation
🔹 Gentle, low-phototoxicity imaging for long-term live studies
🔹 Imaging workflows designed for complex 3D biology

12/01/2026

𝗦𝗽𝗮𝘁𝗶𝗮𝗹 𝗼𝗺𝗶𝗰𝘀 𝗶𝘀 𝗿𝗲𝘀𝗵𝗮𝗽𝗶𝗻𝗴 𝗵𝗼𝘄 𝘄𝗲 𝘂𝗻𝗱𝗲𝗿𝘀𝘁𝗮𝗻𝗱 𝗰𝗮𝗻𝗰𝗲𝗿—by putting molecular data back into its native tissue context.

This newly published 𝘾𝙖𝙣𝙘𝙚𝙧 𝘾𝙚𝙡𝙡 Review provides a comprehensive roadmap of how spatial transcriptomics, proteomics, metabolomics, and emerging 3D technologies are redefining tumor biology, from immune niches to therapy response. As the field matures, the focus is shifting from proof-of-concept to integration, scalability, and clinical translation.

Importantly, the Review highlights the growing role of 3D and volumetric spatial profiling in capturing tissue architecture beyond 2D sections. 𝗛𝗼𝗹𝗼𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝘆 stands out as a complementary approach, enabling quantitative 3D imaging of thick tissues and organoids without staining or physical sectioning—preserving native structure while adding spatial and temporal depth.

At Tomocube, Inc., we’re proud to see holotomography recognized as part of this evolving spatial omics ecosystem—supporting researchers with label-free, quantitative 3D insights that bridge structure, function, and time.

👉 Read the full Review: https://doi.org/10.1016/j.ccell.2025.12.009

08/01/2026

🚨 𝗡𝗲𝘄 𝗔𝗜-𝗽𝗼𝘄𝗲𝗿𝗲𝗱 𝘁𝗼𝗼𝗹 𝗳𝗼𝗿 𝗰𝗹𝗮𝘀𝘀𝗶𝗳𝘆𝗶𝗻𝗴 𝗰𝗲𝗹𝗹 𝗱𝗲𝗮𝘁𝗵—𝗹𝗮𝗯𝗲𝗹-𝗳𝗿𝗲𝗲 & 𝗿𝗲𝗮𝗹-𝘁𝗶𝗺𝗲!

We’re excited to share the very first 𝗵𝗼𝗹𝗼𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝘆-𝗯𝗮𝘀𝗲𝗱 𝘀𝘁𝘂𝗱𝘆 𝗽𝘂𝗯𝗹𝗶𝘀𝗵𝗲𝗱 𝗶𝗻 𝟮𝟬𝟮𝟲, showcasing the strength of our continued collaboration between Tomocube, Inc. and the 𝗞𝗔𝗜𝗦𝗧 𝗕𝗠𝗢𝗟 𝗟𝗮𝗯. Huge congratulations to the entire research team on this outstanding work! 🎉

Challenges in conventional cell death pathway classification methods:

❌ Fluorescence-based method: phototoxicity, bleaching, and limited duration for live-cell imaging.

❌ Existing label-free approaches: limited resolution and morphological insight, restricted classification (live or dead only), and lack of generalizability.

New study propose a 3D + deep learning framework that:

✅ Classifies apoptosis, necroptosis, necrosis, live-control, and drug-treated cells
✅ Achieves 97.2 ± 2.8% accuracy in HeLa cells
✅ Works in dense, unsegmented fields, up to 70% confluency
✅ Detects necroptotic changes 4–6 hrs earlier than FL markers (Annexin V/PI)
✅ Fully label-free, non-invasive, and scalable for high-throughput drug screening

A major step forward in dynamic, morphology-driven phenotyping. Read more: https://doi.org/10.1002/aisy.202500633

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05/01/2026

We’re excited to kick off our very first event of 2026 at the LFD/AIM FLAIR Workshop, taking place January 12–15, at the University of California, Irvine.

At the event, we’ll showcase how you can enrich your fluorescence workflow with label-free, quantitative 3D holotomography:

✔️ Correlative holotomography + spinning disk confocal
✔️ Quantitative RI-based measurements for phenotype interpretation
✔️ Gentle, low-phototoxicity imaging for long-term live cell studies
✔️ Built for organoids and advanced 3D cell models, where context matters

If you’re attending, let’s connect and talk about correlative 3D imaging.

23/12/2025

As 2025 comes to a close, we’re feeling incredibly grateful. ✨

To our global community of scientists, collaborators, and partners—thank you for your trust, curiosity, and shared discoveries throughout the year. From the new platform launch to growing recognition and inspiring research across the life sciences, 2025 was shaped by 𝙮𝙤𝙪.

We’re excited to carry this momentum into the new year, with new possibilities, deeper collaborations, and even more meaningful insights ahead.

Wishing you a warm December and a bright start to 2026.
Thank you for being part of the Tomocube community. 🌱