TOMOCUBE

10/12/2025

🚨 𝗟𝗮𝘀𝘁 𝗥𝗲𝗺𝗶𝗻𝗱𝗲𝗿 — 𝗪𝗲𝗯𝗶𝗻𝗮𝗿 𝗧𝗼𝗺𝗼𝗿𝗿𝗼𝘄!

We’re wrapping up our countdown with one final highlight: this session will feature a case study conducted by Gustave Roussy (IGR) research team, presented by Lucile Mercier (IGR & Okomera), together with Jaehyeok Lee (Tomocube).

Join us to see how 𝗵𝗼𝗹𝗼𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝘆 + 𝗺𝗶𝗰𝗿𝗼𝗳𝗹𝘂𝗶𝗱𝗶𝗰𝘀 enable powerful patient-derived organoid drug screening workflows.

See you there!

📅 Dec 11 | 🕗 11 PM KST / 3 PM CET / 9 AM EST

👉 Don’t miss out: https://us02web.zoom.us/webinar/register/WN_u_JwzNIOQhyLA_N4Knz3WA

08/12/2025

📢 2025 — Day 2 starting soon!

Yesterday was an amazing start — full of great conversations, insightful questions, and inspiring energy.

If you're in Philadelphia, come meet the team at 📍Booth #406 to discuss our HT-X1 Series and TomoAnalysis and explore potential collaborations.

Don’t forget to visit our poster presentation on hepatic stellate cell activation tomorrow—we’d love to share insights and ideas with you!

📅 Tuesday, December 9
⏰ 2:15 PM – 3:45 PM
📌 Presentation: B572 (P1694)

05/12/2025

⏰ 𝗢𝗻𝗲 𝗪𝗲𝗲𝗸 𝗟𝗲𝗳𝘁 — 𝗛𝗮𝘃𝗲 𝗬𝗼𝘂 𝗥𝗲𝗴𝗶𝘀𝘁𝗲𝗿𝗲𝗱?

Our special joint webinar is happening next week on December 11! If you’re working with organoids, microfluidics, or label-free imaging, this is a session you won’t want to miss.

📅 December 11, 2025
🕗 11 PM (KST) / 3 PM (CET) / 9 AM (EST)

Expect practical workflows, live discussion, and expert tips in label-free 3D imaging and microfluidics-driven assays.

👉 Secure your spot today:
https://us02web.zoom.us/webinar/register/WN_u_JwzNIOQhyLA_N4Knz3WA

03/12/2025

🎉 Congratulations to Prof. Sung Gap Im’s research group at KAIST and their collaborators on their recent publication in Advanced Materials!

Their new study presents an exciting breakthrough for the future of intestinal stem-cell therapy. The team engineered a fully synthetic, xenogeneic-free culture surface (PLUS) that significantly enhances stem-cell adhesion, spreading, and 1.8× faster migration, offering 𝗮 𝘀𝘁𝗮𝗯𝗹𝗲 𝗮𝗻𝗱 𝘀𝗰𝗮𝗹𝗮𝗯𝗹𝗲 𝗽𝗹𝗮𝘁𝗳𝗼𝗿𝗺 𝗳𝗼𝗿 𝗿𝗲𝗴𝗲𝗻𝗲𝗿𝗮𝘁𝗶𝘃𝗲 𝗺𝗲𝗱𝗶𝗰𝗶𝗻𝗲

Label-free 3D holotomography enabled the team to visualize—in real time—𝘁𝗵𝗲 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝗺𝗶𝗴𝗿𝗮𝘁𝗶𝗼𝗻 𝗼𝗳 𝗶𝗻𝘁𝗲𝘀𝘁𝗶𝗻𝗮𝗹 𝘀𝘁𝗲𝗺 𝗰𝗲𝗹𝗹𝘀 𝗼𝗻 𝘁𝗵𝗲 𝗣𝗟𝗨𝗦 𝘀𝘂𝗿𝗳𝗮𝗰𝗲. Using quantitative refractive-index imaging, the researchers tracked colony movement, lamellipodia formation, and cytoskeletal remodeling without dyes or phototoxicity, providing clear mechanistic insights into how the engineered surface accelerates epithelial repair.

This is a remarkable achievement that advances both biomaterial engineering and stem-cell biology.

https://advanced.onlinelibrary.wiley.com/doi/10.1002/adma.202513371

This study introduces a PoLymer-coated Ultra-stable Surface (PLUS), a nitrogen plasma-treated poly(ethyleneglycoldimethacrylate), as a stable xenogeneic-free platform for intestinal stem cell culture...

02/12/2025

📢 𝗧𝗼𝗺𝗼𝗰𝘂𝗯𝗲 𝗶𝘀 𝗵𝗲𝗮𝗱𝗶𝗻𝗴 𝘁𝗼 𝘁𝗵𝗲 𝟭𝘀𝘁 𝗔𝗻𝗻𝘂𝗮𝗹 𝗠𝗲𝗲𝘁𝗶𝗻𝗴 𝗼𝗳 𝗜𝗻𝗱𝗶𝗮 𝗕𝗶𝗼𝗜𝗺𝗮𝗴𝗶𝗻𝗴!

For two full days from Dec 11–12, we’re excited to join this landmark gathering of researchers, imaging experts, and technology innovators from across India. Visit our booth to explore how the HT-X1 Series and TomoAnalysis bring label-free 3D clarity and AI-powered insights to your research.

𝗖𝗮𝘁𝗰𝗵 𝗼𝘂𝗿 𝗧𝗲𝗰𝗵 𝗕𝗶𝘁𝗲 𝗧𝗮𝗹𝗸:
🗓️ Day 2 - Friday, Dec 12
⏰ 12:20–13:00

See you in Mysuru!

27/11/2025

📢 𝗧𝗼𝗺𝗼𝗰𝘂𝗯𝗲 𝗥𝗲𝘁𝘂𝗿𝗻𝘀 𝘁𝗼 𝗔𝗦𝗖𝗕 | 𝗘𝗠𝗕𝗢 — 𝗖𝗲𝗹𝗹 𝗕𝗶𝗼 𝟮𝟬𝟮𝟱!

We’re excited to be back at 2025, an event we proudly join every year to reconnect with the global cell biology community and share the latest in label-free imaging innovation.

Visit us at Booth #406 to explore the capabilities of the HT-X1 Series and TomoAnalysis—our multimodal imaging and AI-powered analysis platform transforming how scientists investigate live cells, tissues, and organoids.

🧬 𝗣𝗼𝘀𝘁𝗲𝗿 𝗣𝗿𝗲𝘀𝗲𝗻𝘁𝗮𝘁𝗶𝗼𝗻

Don’t miss our poster on Phenotypic and Drug-Response Profiling of Hepatic Stellate Cell Activation, part of the session Advances in Cell Biology Tools and Technologies – Image-Based Phenotyping.

📅 Tuesday, December 9
⏰ 2:15 PM – 3:45 PM
📌 Presentation No.: P1694

We look forward to connecting with you again this year!

21/11/2025

𝗝𝗼𝗶𝗻 𝗢𝘂𝗿 𝗦𝗽𝗲𝗰𝗶𝗮𝗹 𝗝𝗼𝗶𝗻𝘁 𝗪𝗲𝗯𝗶𝗻𝗮𝗿!

Our October case study on holotomography + microfluidics for patient-derived organoid drug screening received incredible interest, and now we’re taking it a step further with a 𝗮 𝘀𝗽𝗲𝗰𝗶𝗮𝗹 𝗹𝗶𝘃𝗲 𝘀𝗲𝘀𝘀𝗶𝗼𝗻 𝘁𝗵𝗶𝘀 𝗗𝗲𝗰𝗲𝗺𝗯𝗲𝗿.

🔬 Lucile Mercier (Okomera), the scientist behind the experiment, will share exclusive firsthand insights.

🤖 Joey Lee (Tomocube) will show how AI-powered TomoAnalysis elevates organoid-based drug screening.

📅 December 11, 2025
🕗 11 PM (KST) / 3 PM (CET) / 9 AM (EST)

Expect expert tips, live Q&A, practical workflows, and fresh updates in label-free 3D imaging & droplet-based microfluidics.

👉 Don’t miss this deep dive into real-world organoid research! Register now: https://us02web.zoom.us/webinar/register/WN_u_JwzNIOQhyLA_N4Knz3WA

19/11/2025

𝗢𝘂𝗿 𝗡𝗼𝘃𝗲𝗺𝗯𝗲𝗿 𝗻𝗲𝘄𝘀𝗹𝗲𝘁𝘁𝗲𝗿 𝗶𝘀 𝗵𝗲𝗿𝗲.

This month, we look at the growing shift toward label-free imaging, highlighted in the 𝘕𝘢𝘵𝘶𝘳𝘦 𝘔𝘦𝘵𝘩𝘰𝘥𝘴 feature "Life Beyond Labels" with insights from our CEO YongKeun Park.

We also share how holotomography is helping researchers visualize true cell biology—and spotlight two recent studies where a label-free approach uncovered insights traditional methods missed.

📬 Read more in the November edition.

Tomocube offers AI-powered, label-free 3D imaging of live cells, tissues, and organoids with the HT-X1 Holotomography series. Unlock new possibilities in your research.

18/11/2025

A warm thank you to 𝗣𝗿𝗼𝗳𝗲𝘀𝘀𝗼𝗿 𝗬𝗼𝗻𝗴 𝗬𝗲𝗼𝗻 𝗖𝗵𝗼 from the Catholic University of Korea for sharing this happy moment with us, captured while holding a holotomography image of 𝗞𝗮𝗿𝘆𝗼𝗽𝘁𝗼𝘀𝗶𝘀—a unique form of regulated cell death marked by striking nuclear transformations.

Professor Cho’s study sheds new light on how this process begins, revealing key molecular events that lead to the sudden rupture of the nuclear membrane. His team also used holotomography to record 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁-𝗲𝘃𝗲𝗿 𝘁𝗶𝗺𝗲𝗹𝗮𝗽𝘀𝗲 of this dramatic transition, offering an unprecedented view of the subcellular dynamics from initiation to completion. The framed image he’s holding comes directly from this research and its timelapse findings.

At Tomocube, we aim to make our customers happy in every important moment. As a small gesture, we’re delighted to share this memory with Professor Cho and celebrate his groundbreaking work.

Explore his work: https://www.nature.com/articles/s12276-024-01195-1

17/11/2025

💡[𝗣𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗵𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁] 𝗙𝗼𝗹𝗹𝗶𝗰𝗹𝗲 𝗟𝘂𝗺𝗶𝗻𝗼𝗴𝗲𝗻𝗲𝘀𝗶𝘀: 𝗔 𝗖𝗲𝗹𝗹𝘂𝗹𝗮𝗿 𝗣𝗵𝗮𝘀𝗲 𝗧𝗿𝗮𝗻𝘀𝗶𝘁𝗶𝗼𝗻

A recent preprint from the National University of Singapore and collaborators reveals that mammalian follicle lumen formation behaves like a physical phase transition. By combining quantitative timelapse imaging, molecular perturbations, and computational modeling, the team found that fluid-filled gaps inside developing follicles evolve through a “critical” regime, where dynamic cellular rearrangements and controlled cell death give rise to the large fluid cavity essential for oocyte maturation.

Holotomography played an important role in this discovery — enabling label-free, long-term visualization of granulosa cell motion, tissue fluidity, and cell death dynamics with minimal disturbance.

This discovery reframes follicle development as a biophysical phenomenon, with implications for fertility research and assisted reproduction.

Explore the study: https://www.biorxiv.org/content/10.1101/2025.09.09.674793v1

12/11/2025

Hep3B — a human liver cancer cell line — imaged 𝗹𝗮𝗯𝗲𝗹-𝗳𝗿𝗲𝗲 with the 𝗧𝗼𝗺𝗼𝗰𝘂𝗯𝗲 𝗛𝗧-𝗫𝟭™ 𝗺𝗶𝗻𝗶.

At just one-third the size and weight of our flagship model, the HT-X1™ mini delivers the 𝘀𝗮𝗺𝗲 𝗽𝗿𝗼𝘃𝗲𝗻 𝗼𝗽𝘁𝗶𝗰𝗮𝗹 𝗽𝗿𝗶𝗻𝗰𝗶𝗽𝗹𝗲𝘀, 𝗿𝗲𝘀𝗼𝗹𝘂𝘁𝗶𝗼𝗻, 𝗮𝗻𝗱 𝗮𝗻𝗮𝗹𝘆𝘁𝗶𝗰𝗮𝗹 𝗽𝗼𝘄𝗲𝗿 as Tomocube’s second-generation holotomography systems.

Purpose-built to fit seamlessly into any lab environment, it provides world-class holotomography without compromise.

🔗 Learn more about the HT-X1 mini: https://tomocube.com/products/htx1_mini

07/11/2025

[𝗣𝘂𝗯𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 𝗵𝗶𝗴𝗵𝗹𝗶𝗴𝗵𝘁]

📰 Recent study in 𝘊𝘩𝘦𝘮𝘪𝘤𝘰-𝘉𝘪𝘰𝘭𝘰𝘨𝘪𝘤𝘢𝘭 𝘐𝘯𝘵𝘦𝘳𝘢𝘤𝘵𝘪𝘰𝘯𝘴 from a research team in Taiwan reports that the natural lignan 𝗝𝘂𝘀𝘁𝗶𝗰𝗶𝗱𝗶𝗻 𝗔 (𝗝𝗔) 𝗶𝗻𝗱𝘂𝗰𝗲𝘀 𝗕𝗡𝗜𝗣𝟯-𝗺𝗲𝗱𝗶𝗮𝘁𝗲𝗱 𝗺𝗶𝘁𝗼𝗽𝗵𝗮𝗴𝘆 𝗶𝗻 𝗛𝗥𝗔𝗦-𝗺𝘂𝘁𝗮𝗻𝘁 𝗯𝗹𝗮𝗱𝗱𝗲𝗿 𝗰𝗮𝗻𝗰𝗲𝗿 𝗰𝗲𝗹𝗹𝘀. This process suppresses tumor growth and enhances chemosensitivity to cisplatin + gemcitabine.

Using the Tomocube holotomography system, the researchers obtained label-free, live-cell 3D insights into mitochondrial changes, showing:

✔️ Loss of mitochondrial mass

✔️ Fragmentation preceding mitophagy

✔️ Real-time mitochondrial dynamics under JA treatment

Restoring mitophagy emerges as a targetable niche in bladder cancer, offering a promising strategy to overcome drug resistance.

Read the article: https://www.sciencedirect.com/science/article/abs/pii/S0009279725003539