TOMOCUBE

03/04/2026

We’re pleased to welcome a research team from the Universidad de Concepción (Chile) to our HQ in Daejeon, led by 𝗣𝗿𝗼𝗳. 𝗙𝗿𝗮𝗻𝗰𝗶𝘀𝗰𝗼 𝗝𝗮𝘃𝗶𝗲𝗿 𝗡𝘂𝗮𝗹𝗮𝗿𝘁 𝗦𝗮𝗻𝘁𝗮𝗻𝗱𝗲𝗿.

As part of their visit, 𝗗𝗿. 𝗟𝘂𝗰𝗶𝗮𝗻𝗼, who has been actively using the HT-X1 Plus system in their lab, will lead a customer seminar to share their experience and research progress.

Since the system was installed just a few months ago, the team has already explored a wide range of applications—from cancer biology to stem cell research—while building collaborations across local and international partners.

This visit represents more than a single seminar—it reflects how new imaging technologies are adopted and developed through close collaboration, shared expertise, and growing research networks across regions.

📅 April 7 | 10:30–11:30 AM
📍 Tomocube HQ, Daejeon
✍️ Join us: https://shorturl.at/BjhLv

We look forward to welcoming the team and continuing to build strong, meaningful connections within the global research community.

01/04/2026

Label-free diagnostics continue to evolve, as shown in a recent study published in Materials Today Advances.

In this work, Prof. Chan-Gi Pack and colleagues developed a multimodal imaging platform that combines holotomography with Raman spectroscopy to uncover both structural and molecular signatures of eosinophils—enabling highly accurate identification of Eosinophilic Granulomatosis with Polyangiitis (EGPA).

By pairing 3D refractive index maps with chemically specific Raman profiles, the team discovered that EGPA eosinophils contain condensed, high-RI granules enriched with disulfide-bond–related protein signals, along with distinctive lipid redistribution patterns. When Raman signals were analyzed specifically within these high-RI regions, diagnostic classification accuracy rose to 96%—showing how holotomography’s structural context directly strengthens molecular interpretation.

This study highlights a powerful concept: integrating physical structure with chemical identity can reveal disease phenotypes that neither modality could resolve alone. The result is a compelling step toward label-free, subcellular-resolution precision diagnostics for eosinophilic disorders.

Link to the study: https://doi.org/10.1016/j.mtadv.2026.100705

30/03/2026

Two continents, one mission: bringing closer to the scientific community.

This week, we’re at (U.S.) and – Focus on Microscopy (Europe)—connecting with researchers and sharing what’s possible with label-free 3D imaging.

𝗔𝗕𝗥𝗙 𝟮𝟬𝟮𝟲 | 𝗣𝗶𝘁𝘁𝘀𝗯𝘂𝗿𝗴𝗵

📍 Booth #721
📌 Don’t miss our Poster #44 today (Mar 30)| 12:30 – 1:30 PM (ET) | Exhibit Hall

𝗙𝗢𝗠 | 𝗦𝘁𝗼𝗰𝗸𝗵𝗼𝗹𝗺, 𝗦𝘄𝗲𝗱𝗲𝗻

We’re joining the microscopy community to explore the latest innovations shaping biological and biomedical imaging.

At both events, we’re showcasing how holotomography enables label-free, quantitative 3D imaging of live cells, supporting long-term, high-resolution studies without perturbation.

If you’re attending either event, come find us—we’d love to connect and hear about your research.

16/03/2026

𝗢𝘃𝗲𝗿𝘃𝗶𝗲𝘄 𝗦𝗽𝗼𝘁𝗹𝗶𝗴𝗵𝘁: 𝗧𝗵𝗲 𝗙𝘂𝘁𝘂𝗿𝗲 𝗼𝗳 𝗜𝗺𝗮𝗴𝗶𝗻𝗴 𝗜𝘀 𝗛𝗲𝗿𝗲

Holotomography is no longer just an emerging technique — it’s rapidly becoming a transformative platform for biomedical discovery. A new preprint highlights how HT has evolved from a niche optical method into a powerful engine for AI-driven, quantitative, multimodal phenotyping.

𝗪𝗵𝗮𝘁 𝗺𝗮𝗸𝗲𝘀 𝘁𝗵𝗶𝘀 𝗲𝘅𝗰𝗶𝘁𝗶𝗻𝗴?

✅ HT reconstructs 3D refractive-index maps of cells and tissues, enabling high-resolution, label-free imaging with minimal perturbation.

✅ Recent advances combine HT with deep learning, unlocking virtual staining, automated classification, and molecular-level inference from purely physical data.

✅ The technology is expanding into complex systems — from organoids to thick tissues — and integrating with modalities like Raman and Brillouin microscopy for morpho-chemical insights.

In 2025 alone, 64 studies demonstrated HT’s impact across cell biology, cancer research, microbiology, and regenerative medicine, signaling rapid adoption across disciplines. The field is shifting from imaging structures to decoding biological states. With AI, quantitative physics, and multimodal data, HT is positioned to become a foundational technology for digital pathology, drug discovery, and next-generation phenotyping pipelines.

Go to the review for more: https://doi.org/10.48550/arXiv.2601.02611

10/03/2026

The rhythm of life—captured at the cellular level.

These beating cells are hiPSC-derived cardiomyocytes, imaged using the HT-X1 system.

Without fluorescent labels or dyes, HT-X1 reveals the natural contraction dynamics of living heart cells in real time. Each pulse reflects the coordinated mechanical activity of the cells as they beat in culture.

From stem cell biology to cardiotoxicity testing, watching cells beat can reveal far more than static snapshots ever could.

Holotomography for 🔬 Real-time, 📈 Quantitative, and 🧬 Label-free imaging!

06/03/2026

Congratulations to the research team from the Catholic University of Korea and collaborators on their new publication in Cell Reports Physical Science. 🎉

In this work, the authors introduce a tunable nitrogen–oxygen plasma coating strategy that transiently reverses the surface charge of cell membrane-derived nanovesicles, remodels their protein corona, and significantly enhances systemic doxorubicin delivery and antitumor efficacy.

Using live-cell 3D holotomography imaging combined with fluorescence detection, the team visualized real-time intracellular trafficking, nuclear delivery of doxorubicin, and apoptosis progression. This quantitative phase imaging approach enabled precise monitoring of vesicle internalization kinetics and provided dynamic mechanistic insight into how plasma-induced surface modulation enhances endocytic uptake and therapeutic performance.

A compelling demonstration of how physical surface engineering and advanced holotomography can synergize to optimize next-generation nanomedicine platforms.

https://www.sciencedirect.com/science/article/pii/S2666386425006836

03/03/2026

𝗔𝗱𝘃𝗮𝗻𝗰𝗲𝗱 𝟯𝗗 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝘀𝗵𝗼𝘂𝗹𝗱𝗻’𝘁 𝗺𝗲𝗮𝗻 𝗰𝗼𝗺𝗽𝗹𝗶𝗰𝗮𝘁𝗲𝗱 𝘄𝗼𝗿𝗸𝗳𝗹𝗼𝘄.

The 𝗛𝗧-𝗫𝟭 𝗦𝗲𝗿𝗶𝗲𝘀 is designed for advanced 3D label-free imaging—without adding complexity to your experiment.

🔹 Seamless handling of various biological models
🔹 Compatibility with diverse labware
🔹 Autofocus
🔹 Automatic calibration
🔹Environmental control

From setup to acquisition, everything is designed to reduce friction in your daily workflow—so you can spend more time analyzing data, not adjusting optics.

See how simplified 3D imaging looks in practice.
YouTube: https://www.youtube.com/watch?v=biRrxmXX2g8

23/02/2026

Congratulations to the authors from Mayo Clinic and their collaborators on the publication of this exciting work in Nature Immunology! 🎉

In this study, the team demonstrates that SIRT2-mediated deacetylation of LCK at lysine 228 fine-tunes T cell receptor (TCR) signaling strength, thereby shaping T cell activation, thymic selection, repertoire diversity, and antitumor immunity.

Using , our users were able to visualize and quantitatively analyze cellular morphology and dynamic changes in T cells in a label-free manner, providing high-resolution, 3D insights into how modulation of SIRT2 activity impacts T cell functional states and signaling responsiveness. This advanced imaging approach complemented the molecular and biochemical analyses by enabling precise, non-invasive characterization of cellular phenotypes associated with altered TCR signaling.

Go to the article: https://www.nature.com/articles/s41590-025-02377-3

Phosphorylation-dephosphorylation and ubiquitination tune TCR signaling to avoid self-reactivity. Kim and colleagues show that acetylation also modulates TCR signaling.

16/02/2026

🧧✨ Happy Lunar New Year from Tomocube! ✨🧧

While the calendar year is already underway, the Lunar New Year offers a special moment to pause, reconnect, and look ahead with a fresh perspective.

We’d like to take this opportunity to thank our global community—partners, customers, and collaborators—for the ideas, conversations, and shared progress that continue to shape what we do.

May the months ahead bring steady momentum, inspiring breakthroughs, and plenty of moments worth celebrating, wherever you are in the world. We’re grateful to be on this journey with you. 🍊

09/02/2026

🚀 𝗤𝘂𝗮𝗻𝘁𝗶𝘁𝗮𝘁𝗶𝘃𝗲, 𝗟𝗮𝗯𝗲𝗹-𝗙𝗿𝗲𝗲 𝗢𝗿𝗴𝗮𝗻𝗼𝗶𝗱 𝗗𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝟯𝗗

We’re excited to share a recent preprint from a collaborative study between Tomocube, Inc. and 𝗞𝗔𝗜𝗦𝗧 𝗕𝗠𝗢𝗟, introducing a robust framework for morphology-preserving, quantitative analysis of live dynamics using holotomography.

🔬 What’s the challenge?
- Organoids undergo complex 3D dynamics (expansion, collapse, fusion)
- Fluorescence imaging alone limits long-term, quantitative studies due to labeling, phototoxicity, axial distortion & reconstruction artifacts

💡 What’s new in this work?
- Introduces Morphology-Preserving Holotomography (MP-HT)
- A physics-aware representation that mitigates missing-cone artifacts
- Enables robust 3D segmentation of epithelium & lumen
- Supports morphology-independent RI & dry-mass quantification

📊 Why it matters
- Long-term, label-free tracking of live organoid dynamics
- Quantitative readouts of epithelial–lumen remodeling, dry-mass density, and total dry mass
- Captures biophysical changes difficult to observe with fluorescence

Read more: https://arxiv.org/abs/2512.22486

03/02/2026

📍 LMA2026 — Good Morning from the Symposium Floor

Light Microscopy Australia’s 5th National Symposium is officially underway. We’re excited to be here together with our partner, Scitech, kicking off a full week of conversations around live imaging, advanced light microscopy, and the future of image analysis.

Looking forward to connecting with the community and sharing how label-free, quantitative 3D holotomography complements today’s imaging workflows.

Let the week begin!

02/02/2026

We’re excited to share that Tomocube will be joining SLAS 2026! 🎉

At this year’s show, we’ll be highlighting how HT-X1 Plus supports 𝗵𝗶𝗴𝗵-𝘁𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁, 𝗮𝘂𝘁𝗼𝗺𝗮𝘁𝗶𝗼𝗻-𝗿𝗲𝗮𝗱𝘆 𝗵𝗼𝗹𝗼𝘁𝗼𝗺𝗼𝗴𝗿𝗮𝗽𝗵𝘆—designed for labs that need speed, consistency, and scalable data generation. Our focus is on building an efficient data factory: smart scheduling, reliable auto-focus, and streamlined workflows that help teams acquire large, reproducible datasets with less manual effort.

If you’re working in high-throughput screening, workflow automation, or advanced imaging, come see how semi-automation can make a real difference in day-to-day experiments.

📍 See you at SLAS 2026—let’s talk automation, efficiency, and better data.