13/11/2025
Surgical Resection after Chemoradiotherapy with a Higher Radiation Dose in Locally Advanced Esophageal Cancer: A Retrospective Study from Taiwan
J Chest Surg 2025; 58: 239-251
https://doi.org/10.5090/jcs.25.040
This study evaluates the outcomes of patients with locally advanced esophageal cancer who underwent surgery after high-dose neoadjuvant chemoradiotherapy (50.4 Gy). Nearly half of the patients achieved a pathologic complete response, which was strongly associated with significantly improved long-term survival. The results suggest that high-dose nCRT followed by surgery is safe and can offer substantial survival benefits, particularly for those achieving complete tumor eradication.